Accessing Nucleosomal DNA

Project Information

NucEM

Grant agreement ID: 884331

DOI

10.3030/884331

EC signature date 18 September 2020

Start date 1 March 2021

End date 28 February 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 100 929,00

EU contribution

€ 2 100 929,00

Coordinated by

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (16)

A Multicomponent Reaction-Based Platform Opens New Avenues in Aryl Hydrocarbon Receptor Modulation

Author(s): Pau Nadal Rodríguez, Frederick Hartung, Marina Pedrola, Seemon Coomar, Alejandro Diaz-Moreno, Anna M. Hätälä, Katharina M. Rolfes, Ismael Sánchez-Vera, Joan Gil, Elies Molins, Antonio Viayna, Alexander Hanzl, Nicolas H. Thomä, Thomas Haarmann-Stemmann, F. Javier Luque, Rodolfo Lavilla, Ouldouz Ghashghaei
Published in: ACS Central Science, Issue 11, 2025, Page(s) 629-641, ISSN 2374-7943
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acscentsci.5c00194

Pioneer factors: Emerging rules of engagement for transcription factors on chromatinized DNA

Author(s): Manuel Carminati, Luca Vecchia, Lisa Stoos, Nicolas H. Thomä
Published in: Current Opinion in Structural Biology, Issue 88, 2024, Page(s) 102875, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2024.102875

Design principles for cyclin K molecular glue degraders

Author(s): Zuzanna Kozicka, Dakota J. Suchyta, Vivian Focht, Georg Kempf, Georg Petzold, Marius Jentzsch, Charles Zou, Cristina Di Genua, Katherine A. Donovan, Seemon Coomar, Marko Cigler, Cristina Mayor-Ruiz, Jonathan L. Schmid-Burgk, Daniel Häussinger, Georg E. Winter, Eric S. Fischer, Mikołaj Słabicki, Dennis Gillingham, Benjamin L. Ebert & Nicolas H. Thomä
Published in: Nature Chemical Biology, 2023, ISSN 1552-4469
Publisher: Nature
DOI: 10.1038/s41589-023-01409-z

Cooperation between bHLH transcription factors and histones for DNA access

Author(s): "Alicia K Michael # 1 2 , Lisa Stoos # 1 2 , Priya Crosby 3 , Nikolas Eggers 4 , Xinyu Y Nie 5 , Kristina Makasheva 6 , Martina Minnich 7 , Kelly L Healy 8 , Joscha Weiss 1 2 , Georg Kempf 1 , Simone Cavadini 1 , Lukas Kater 1 , Jan Seebacher 1 , Luca Vecchia 1 , Deyasini Chakraborty 1 2 , Luke Isbel 1 , Ralph S Grand 1 , Florian Andersch 7 , Jennifer L Fribourgh 3 , Dirk"
Published in: Nature, 2023, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-06282-3

A deep dive into degrader-induced protein-protein interfaces

Author(s): Pius Galli 1 , Carlos Pla-Prats 1 , Nicolas H Thomä 2
Published in: Trends Pharmacol Sci, 2023, ISSN 0165-6147
Publisher: Elsevier BV
DOI: 10.1016/j.tips.2023.02.001

Recognition of the CCT5 di-Glu degron by CRL4DCAF12 is dependent on TRiC assembly

Author(s): Carlos Pla-Prats 1 2 , Simone Cavadini 1 , Georg Kempf 1 , Nicolas H Thomä 1
Published in: EMBO J ., 2023, ISSN 1460-2075
Publisher: Embo Press
DOI: 10.15252/embj.2022112253

Niclosamide: CRL4^AMBRA1 mediated degradation of cyclin D1 following mitochondrial membrane depolarization

Author(s): Seemon Coomar, Jessica A. Gasser, Mikołaj Słabicki, Katherine A. Donovan, Eric S. Fischer, Benjamin L. Ebert, Dennis Gillingham, Nicolas H. Thomä
Published in: RSC Medicinal Chemistry, Issue 16, 2025, Page(s) 3049-3057, ISSN 2632-8682
Publisher: RSC Medicinal Chemistry
DOI: 10.1039/d5md00054h

Rational Design of CDK12/13 and BRD4 Molecular Glue Degraders

Author(s): Zhe Zhuang, Woong Sub Byun, Zuzanna Kozicka, Katherine A. Donovan, Brendan G. Dwyer, Abby M. Thornhill, Hannah M. Jones, Zixuan Jiang, Xijun Zhu, Eric S. Fischer, Nicolas H. Thomä, Nathanael S. Gray
Published in: Angewandte Chemie International Edition, Issue 64, 2025, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202508427

Quality control of protein complex assembly by the ubiquitin-proteasome system

Author(s): Carlos Pla-Prats, Nicolas H Thomä
Published in: Trends Cell Biol, 2022, ISSN 0962-8924
Publisher: Elsevier BV
DOI: 10.1016/j.tcb.2022.02.005

Primed for degradation: How weak protein interactions enable molecular glue degraders

Author(s): Alexander Hanzl, Clara Inghelram, Stefan Schmitt, Nicolas H. Thomä
Published in: Current Opinion in Structural Biology, Issue 92, 2025, Page(s) 103052, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2025.103052

Reading the chromatinized genome

Author(s): Alicia K Michael, Nicolas H Thomä
Published in: Cell, 2021, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2021.05.029

UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability

Author(s): Jonathan M Tsai 1 , Jacob D Aguirre 2 , Yen-Der Li 3 , Jared Brown 4 , Vivian Focht 2 , Lukas Kater 2 , Georg Kempf 2 , Brittany Sandoval 5 , Stefan Schmitt 2 , Justine C Rutter 5 , Pius Galli 6 , Colby R Sandate 2 , Jevon A Cutler 7 , Charles Zou 5 , Katherine A Donovan 8 , Ryan J Lumpkin 8 , Simone Cavadini 2 , Paul M C Park 5 , Quinlan Sievers 5 , Charlie Hatton 7 , Elizabet
Published in: Mol. cell, 2023, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2023.06.028

Nucleosomes specify co-factor access to p53

Author(s): Deyasini Chakraborty, Colby R. Sandate, Luke Isbel, Georg Kempf, Joscha Weiss, Simone Cavadini, Lukas Kater, Jan Seebacher, Zuzanna Kozicka, Lisa Stoos, Ralph S. Grand, Dirk Schübeler, Alicia K. Michael, Nicolas H. Thomä
Published in: Molecular Cell, Issue 85, 2025, Page(s) 2919-2936.e12, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2025.06.027

Orphan quality control shapes network dynamics and gene expression

Author(s): Kevin G Mark 1 , SriDurgaDevi Kolla 1 , Jacob D Aguirre 2 , Danielle M Garshott 1 , Stefan Schmitt 2 , Diane L Haakonsen 3 , Christina Xu 1 , Lukas Kater 2 , Georg Kempf 2 , Brenda Martínez-González 1 , David Akopian 1 , Stephanie K See 4 , Nicolas H Thomä 5 , Michael Rapé 6
Published in: Cell, 2023, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2023.06.015

DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance

Author(s): Martin Schröder, Martin Renatus, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Frederic Sigoillot, Scott Gleim, Therese-Marie Stachyra, Jason R. Thomas, Damien Begue, Maryam Khoshouei, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Benika Pinch, Andreas Hofmann, Markus Schirle, Niko Schmiedeberg, Patricia Imbach, Delphine Gorses, Keith Calki
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-44237-4

Readout of histone methylation by Trim24 locally restricts chromatin opening by p53

Author(s): Luke Isbel 1 2 , Murat Iskar 1 , Sevi Durdu 1 , Joscha Weiss 1 3 , Ralph S Grand 1 4 , Eric Hietter-Pfeiffer 1 3 , Zuzanna Kozicka 1 3 , Alicia K Michael 1 5 , Lukas Burger 1 6 , Nicolas H Thomä 1 , Dirk Schübeler 7 8
Published in: Nat Struct Mol Biol, 2023, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-023-01021-8