The most prevalent type of lung cancers are non-small cell lung cancers (NSCLCs), which have a variety of pathological characteristics. NSCLCs have been identified as a collection of different diseases with cellular and genetic heterogeneity by detailed investigations of lung cancer genomes and signalling pathways during the past ten years (Chen Z. et al. 2014). 85% of lung cancer cases in the United States are NSCLCs. The epidemiology has identified smoking, air pollution, occupational exposure, and alcohol consumption as the main risk factors. At the time of diagnosis, it was discovered that 70% of patients had locally progressed or metastatic disease (Molina JR. et al. 2008). The progression of NSCLCs is influenced by a number of driver mutations, including ROS1, RET, and other translocations; EGFR mutations; KRAS mutations; BRAF mutations; MET splice site mutations (Hirsch, FR., et al 2016). The treatment of lung cancer is drastically altering as a result of targeted medicines. These treatments include pharmaceuticals or biologicals that target immune checkpoint inhibitors, anti-apoptotic molecules implicated in cancer cell survival and proliferation, and driver mutation-targeting agents. With the introduction of new drugs, targets, therapeutic combinations, and drug delivery methods, the field of targeted therapeutic research is advancing every day (Molina JR. et al. 2008).
"BESG" sought to create a therapeutic drug delivery system prototype with improved targeting capabilities for treating non-small cell lung cancer using exosomes modified with the a targeting peptide and loaded with small molecule and nucleic acid. Theranostic and therapeutic agent delivery methodologies were also combined by BESG in order to create advanced drug delivery systems that may one day be used to develop personalized medicines.
The overall objectives of "BESG" includes
a. Development of smart peptide functionalized exosome loaded with small molecule and nucleic acid and/or fluorescent dye
b. Characterization of developed products for their enhanced targeting capabilities, cytotoxicity with NSCLCs
c. Functional studies of developed products in the animal model of NSCLCs.
