Nanoscopy (or single-molecule-localization-microscopy) has developed rapidly in the past 10 years, revolutionising optical imaging (microscopy), bringing new knowledge and facilitating new discoveries in cell biology. Nanoscopy breaks the diffraction limit, the previously impenetrable physical barrier that restricts the optical resolution of a microscope to 250 nanometers (nm) and achieves unprecedented resolutions of 5-10 nm. Thus, thanks to nanoscopy, for the first time today it is possible to see how sub-cellular molecular machineries form and behave inside single cells2 and to characterise and quantify single biological molecules such as proteins, nucleic acids, lipids, at ultra-low concentrations inside the cell.
For the first time since Nobel price 2014 was awarding nanoscopy invention, Abbelight has provided to researchers the most complete and reliable nanoscopy solution on the market with the best imaging resolution; nonetheless, a majority of users also need higher throughput to unravel and understand rare biological events, such as those behind the varying responses to treatment of cancer cells, the challenge of personalized medicine.
However, a Hight-Throughput imaging system with nano-resolution does not exist yet.
That is why Abbelight is moving much further into the highly challenging development of the new HT-SAFeTM platform: the first connected and automated high-throughput / high-content (HT/HC) nanoscope platform. It will fill the gap between existing nanoscopes and existing HT/HC classical microscopes and truly transform the market, improving dramatically research in (cell) biology and enabling discoveries at unprecedented speed and resolution.
