From the launch of the EVOMET project to its conclusion, all activities across the eight Work Packages (WPs) were successfully implemented, in line with the objectives defined in the Description of Action. Minor timeline adjustments were made where necessary to accommodate the needs of the research and training activities, but all milestones were achieved, and deliverables were submitted as planned.
The consortium fostered a highly collaborative and productive working environment, both scientifically and in terms of training. A strong network of interaction emerged among partners, with particular emphasis on collaboration between Early Stage Researchers (ESRs), who built a vibrant peer group. This collaborative spirit was reinforced through annual consortium meetings, thematic workshops, ESR technical meetings, and a wide array of secondments, which facilitated the exchange of expertise and reinforced interdisciplinary research.
Scientific progress was achieved across scientific Work Packages, addressing the core research objectives on cancer cell fate, tumour microenvironment interactions, metastatic latency, and metastatic expansion. Results included the identification of new cellular mechanisms underlying metastatic progression and treatment resistance, the development of novel preclinical models, and insights into tumour–stroma dynamics. These outcomes have been disseminated through 15 peer-reviewed publications (and many others in preparation) and numerous conference presentations, all of which have accelerated the uptake of exploitable results within and outside the network.
Non-scientific Work Packages focused on training, dissemination, management and ethics. The full training programme was delivered, with ESRs receiving both scientific and transferable skills training via consortium-wide events and local institutional offerings. Several ESRs also contributed to academic teaching and supervised Master’s students, further enhancing their preparation for academic and non-academic careers.
The project’s dissemination and communication activities were significantly expanded in the second reporting period. Scientific findings were shared through conferences, institutional channels, and the project website. Synergies between work packages were showcased during joint sessions, publications, and the organization of the final EVOMET conference in Brussels, which highlighted the collective achievements of the consortium to both scientific and stakeholder audiences.
Finally, the successful completion of EVOMET has not only advanced metastasis research but also contributed to the formation of a skilled cohort of researchers. The collaborative foundation established in EVOMET is already continuing through follow-up initiatives, including the new doctoral network, ADAPTMET, which builds on EVOMET's scientific and training legacy.
