Skip to main content
Przejdź do strony domowej Komisji Europejskiej (odnośnik otworzy się w nowym oknie)
polski pl
CORDIS - Wyniki badań wspieranych przez UE
CORDIS
Zawartość zarchiwizowana w dniu 2024-06-10

Role of rap1a in p21ras function

Cel



RaplA and p21ras are small molecular weight GTP-binding proteins involved in the regulation of growth and differentiation. The nucleotide-bound state is regulated by guanine nucleotide exchange factors (GEF) and GTPase activating proteins (GAPs). P21ras mutants which are resistant to GAP and thus constitutively active, are found in 30% of the human tumours. Ras-induced transformaton can be suppressed by raplA, which is 50% homologous to p21ras. The striking observation that raplA and p21ras are identical in the putative effector domain raised the possibility that raplA could share the same effector protein(s) and keep them in a non- productive complex. I would like to use this TMR grant to study the role of raplA-interacting proteins in the function of p21ras. Known raplA-binding proteins (pl20GAP, raf and ralGEF) and newly identified raplA- binding proteins will be characterized.

Dziedzina nauki (EuroSciVoc)

Program(-y)

Temat(-y)

Zaproszenie do składania wniosków

Brak dostępnych danych

System finansowania

RGI - Research grants (individual fellowships)

Koordynator

MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Wkład UE
Brak danych
Adres
201,Rheinlanddamm 201
44139 DORTMUND
Niemcy
Koszt całkowity
Brak danych

Uczestnicy (1)