Cel The de novo design of an artificial protein of the B or A/B class is envisaged. The designed protein will use the topology of a SH3 domain (B) or a IgG binding protein G (A/B) as templates, two small proteins ( 60 residues) extensively studied in the group of L. Serrano at the EMBL. The procedure employed for the design will combine the most recent methods of molecular modelling with experimental methods for the structural characterization of the artificial protein synthesised (CD, NMR). The design procedure will be based on the assembling of structurally related building block from various proteins whose 3-D structure is known. A particular attention will be paid to optimise the packing of amino acids in the interior of the protein since this aspect has been shown to be essential to obtain a well-defined 3-D structure. Dziedzina nauki nauki przyrodniczematematykamatematyka czystatopologianauki przyrodniczenauki biologicznebiochemiabiocząsteczkibiałkanauki przyrodniczenauki chemicznechemia organicznaaminy Program(-y) FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998 Temat(-y) 0302 - Post-doctoral research training grants TL02 - Molecular Biology and Biochemistry Zaproszenie do składania wniosków Data not available System finansowania RGI - Research grants (individual fellowships) Koordynator EUROPEAN MOLECULAR BIOLOGY LABORATORY Adres 1,meyerhofstraße 1 69012 Heidelberg Niemcy Zobacz na mapie Wkład UE Brak danych Uczestnicy (1) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko Not available Francja Wkład UE € 0,00 Adres Zobacz na mapie Środki z innych źródeł Brak danych
