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Zawartość zarchiwizowana w dniu 2024-06-10

Identification of fgf-stimulated signalling pathways critical for angiogenesis

Cel



Research objectives and content The aim is to identify the signal transduction pathways critical for FGF-mediated angiogenesis. The novel immortomouse brain endothelial (IBE) cell line, offers the to potential to disect the pathway critical for FGFmediated tube-formation. Using the innovative approach of transfecting these cells with PDGFR-alpha/FGFR-1 chimeric receptor mutations via retrovirus-mediated gene transfer, I will study the ability of specific mutations to inhibit tube-formation. I will then determine which signal transduction cascades have been perturbed. Furthermore, I will also utilise a yeast two-hybrid system to identify novel proteins which associate with the intracellular domain of the FGFR-1. The biological role of such proteins will then be identified. Training content (objective, benefit and expected impact) I will be trained in a wide range of current molecular biology techniques. Also, I will learn a number of biological assays, critical for studying angiogenesis in a cell model. The benefit of such training is that I will be learning a wide range of skills critical to my scientific development. Since the host lab has renown record in this field I expect to generate novel data.
Links with industry / industrial relevance (22) Identification of pathways critical for angiogenesis will facilitate the development of agents which can regulate such pathways. A pharmaceutical involvement is highly anticipated.

Dziedzina nauki (EuroSciVoc)

Program(-y)

Temat(-y)

Zaproszenie do składania wniosków

Brak dostępnych danych

System finansowania

RGI - Research grants (individual fellowships)

Koordynator

Uppsala University
Wkład UE
Brak danych
Adres
3,Biomedicum, Husargatan
751 23 Uppsala
Szwecja
Koszt całkowity
Brak danych

Uczestnicy (1)