Metabolic flexibility: breaking down food effectively to prolong life

Informacje na temat projektu

MetaFlex

Identyfikator umowy o grant: 638290

DOI 10.3030/638290

Projekt został zamknięty

Data podpisania przez KE 17 Marca 2015

Data rozpoczęcia 1 Kwietnia 2015

Data zakończenia 31 Marca 2020

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity € 1 499 446,25

Wkład UE € 1 499 446,25

Koordynowany przez

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands

Publikacje

Peer reviewed articles (16)

A sensitive mass spectrometry platform identifies metabolic changes of life history traits in C. elegans

Autorzy: Arwen W. Gao, Iliana A. Chatzispyrou, Rashmi Kamble, Yasmine J. Liu, Katharina Herzog, Reuben L. Smith, Henk van Lenthe, Martin A. T. Vervaart, Arno van Cruchten, Angela C. Luyf, Antoine van Kampen, Mia L. Pras-Raves, Frédéric M. Vaz, Riekelt H. Houtkooper
Opublikowane w: Scientific Reports, Numer 7/1, 2017, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-017-02539-w

Mitochondrial quality control pathways as determinants of metabolic health

Autorzy: Ntsiki M. Held, Riekelt H. Houtkooper
Opublikowane w: BioEssays, Numer 37/8, 2015, Strona(/y) 867-876, ISSN 0265-9247
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/bies.201500013

Forward and reverse genetics approaches to uncover metabolic aging pathways in Caenorhabditis elegans

Autorzy: Arwen W. Gao, Jelmi uit de Bos, Mark G. Sterken, Jan E. Kammenga, Reuben L. Smith, Riekelt H. Houtkooper
Opublikowane w: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017, ISSN 0925-4439
Wydawca: Elsevier BV
DOI: 10.1016/j.bbadis.2017.09.006

Tetracycline Antibiotics Impair Mitochondrial Function and Its Experimental Use Confounds Research

Autorzy: I. A. Chatzispyrou, N. M. Held, L. Mouchiroud, J. Auwerx, R. H. Houtkooper
Opublikowane w: Cancer Research, Numer 75/21, 2015, Strona(/y) 4446-4449, ISSN 0008-5472
Wydawca: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-15-1626

Antibiotic use and abuse: A threat to mitochondria and chloroplasts with impact on research, health, and environment

Autorzy: Xu Wang, Dongryeol Ryu, Riekelt H. Houtkooper, Johan Auwerx
Opublikowane w: BioEssays, Numer 37/10, 2015, Strona(/y) 1045-1053, ISSN 0265-9247
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/bies.201500071

A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans

Autorzy: Mandy Koopman, Helen Michels, Beverley M Dancy, Rashmi Kamble, Laurent Mouchiroud, Johan Auwerx, Ellen A A Nollen, Riekelt H Houtkooper
Opublikowane w: Nature Protocols, Numer 11/10, 2016, Strona(/y) 1798-1816, ISSN 1754-2189
Wydawca: Nature Publishing Group
DOI: 10.1038/nprot.2016.106

Sirtuin activation as a therapeutic approach against inborn errors of metabolism

Autorzy: Jeannette C. Bleeker, Riekelt H. Houtkooper
Opublikowane w: Journal of Inherited Metabolic Disease, Numer 39/4, 2016, Strona(/y) 565-572, ISSN 0141-8955
Wydawca: Kluwer Academic Publishers
DOI: 10.1007/s10545-016-9939-8

From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs

Autorzy: Rebecca L McIntyre, Eileen G Daniels, Marte Molenaars, Riekelt H Houtkooper, Georges E Janssens
Opublikowane w: EMBO Molecular Medicine, Numer 11/9, 2019, ISSN 1757-4676
Wydawca: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201809854

Natural genetic variation in C. elegans identified genomic loci controlling metabolite levels

Autorzy: Arwen W. Gao, Mark G. Sterken, Jelmi uit de Bos, Jelle van Creij, Rashmi Kamble, Basten L. Snoek, Jan E. Kammenga, Riekelt H. Houtkooper
Opublikowane w: Genome Research, Numer 28/9, 2018, Strona(/y) 1296-1308, ISSN 1088-9051
Wydawca: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.232322.117

Mitochondrial ubiquinone–mediated longevity is marked by reduced cytoplasmic mRNA translation

Autorzy: Marte Molenaars, Georges E Janssens, Toon Santermans, Marco Lezzerini, Rob Jelier, Alyson W MacInnes, Riekelt H Houtkooper
Opublikowane w: Life Science Alliance, Numer 1/5, 2018, Strona(/y) e201800082, ISSN 2575-1077
Wydawca: EMBO Press, Rockefeller University Press, and Cold Spring Harbor Laboratory Press
DOI: 10.26508/lsa.201800082

Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion

Autorzy: Yasmine J. Liu, Georges E. Janssens, Rebecca L. McIntyre, Marte Molenaars, Rashmi Kamble, Arwen W. Gao, Aldo Jongejan, Michel van Weeghel, Alyson W. MacInnes, Riekelt H. Houtkooper
Opublikowane w: PLOS Genetics, Numer 15/3, 2019, Strona(/y) e1007633, ISSN 1553-7404
Wydawca: Public Library of Science
DOI: 10.1371/journal.pgen.1007633

Pyruvate dehydrogenase complex plays a central role in brown adipocyte energy expenditure and fuel utilization during short-term beta-adrenergic activation

Autorzy: Ntsiki M. Held, Eline N. Kuipers, Michel van Weeghel, Jan Bert van Klinken, Simone W. Denis, Marc Lombès, Ronald J. Wanders, Frédéric M. Vaz, Patrick C. N. Rensen, Arthur J. Verhoeven, Mariëtte R. Boon, Riekelt H. Houtkooper
Opublikowane w: Scientific Reports, Numer 8/1, 2018, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-018-27875-3

A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways

Autorzy: Marte Molenaars, Georges E. Janssens, Evan G. Williams, Aldo Jongejan, Jiayi Lan, Sylvie Rabot, Fatima Joly, Perry D. Moerland, Bauke V. Schomakers, Marco Lezzerini, Yasmine J. Liu, Mark A. McCormick, Brian K. Kennedy, Michel van Weeghel, Antoine H.C. van Kampen, Ruedi Aebersold, Alyson W. MacInnes, Riekelt H. Houtkooper
Opublikowane w: Cell Metabolism, Numer 31/3, 2020, Strona(/y) 549-563.e7, ISSN 1550-4131
Wydawca: Cell Press
DOI: 10.1016/j.cmet.2020.01.011

Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30

Autorzy: Yasmine J. Liu, Rebecca L. McIntyre, Georges E. Janssens, Evan G. Williams, Jiayi Lan, Michel van Weeghel, Bauke Schomakers, Henk van der Veen, Nicole N. van der Wel, Pallas Yao, William B. Mair, Ruedi Aebersold, Alyson W. MacInnes, Riekelt H. Houtkooper
Opublikowane w: Journal of Cell Biology, Numer 219/6, 2020, ISSN 0021-9525
Wydawca: Rockefeller University Press
DOI: 10.1083/jcb.201907067

Mitochondrial cross-compartmental signalling to maintain proteostasis and longevity

Autorzy: Marte Molenaars, Eileen G. Daniels, Amber Meurs, Georges E. Janssens, Riekelt H. Houtkooper
Opublikowane w: Philosophical Transactions of the Royal Society B: Biological Sciences, Numer 375/1801, 2020, Strona(/y) 20190414, ISSN 0962-8436
Wydawca: Royal Society of London
DOI: 10.1098/rstb.2019.0414

Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease

Autorzy: Yasmine J. Liu, Rebecca L. McIntyre, Georges E. Janssens, Riekelt H. Houtkooper
Opublikowane w: Mechanisms of Ageing and Development, Numer 186, 2020, Strona(/y) 111212, ISSN 0047-6374
Wydawca: Elsevier BV
DOI: 10.1016/j.mad.2020.111212