Cel An emerging application of colloidal science, due to the growing social and economic consequences of the obesity crisis in the developed world, is the design of healthier foods to control fat uptake in the diet. Consequently molecular mechanisms of digestion and metabolism of lipids are generating renewed scientific interest. Lipase-colipase complexes adsorb onto the surface of lipid droplets to access and hydrolyse fats into a form absorbed by the body (lipolysis). Studies I made on the recent Marie-Curie action (LIPOGEST) suggest that processed food emulsions could be designed to slow rates of lipolysis, inducing satiety, and lowering fat intake in the diet. Use of nanoscience methods to visualise bile salt adsorption under in vitro duodenum conditions suggest that interfacial structures of protein-stabilised emulsions could be designed rationally to control bile salt adsorption, reducing lipase-colipase adsorption and rates of lipolysis. An important aspect of such design is ensuring that modified interfaces survive digestion conditions in the stomach. LIPOGEST enabled me to investigate the effect of stomach conditions on interfacial structures for the first time, identifying new facets of these processes, such as an unexpected synergism between surfactants and proteolytic enzymes in the proteolysis of interfacial layers. Such knowledge offers routes to control proteolysis enabling successful design of emulsions to control fat intake. In the present proposal I intend to consolidate and expand these findings into how the process of digestion affects the structure and stability of model emulsions and interfacial layers. This information will be obtained by using state-of-the-art colloidal characterisation techniques and theoretical models. Through this approach I aim to understand the role of food structure on lipid digestion and metabolism. The improved understanding of this process could enable the design of food emulsions with specific lipid digestion profiles. Dziedzina nauki engineering and technologyother engineering and technologiesfood technologynatural sciencesbiological sciencesbiochemistrybiomoleculeslipidsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymesmedical and health scienceshealth sciencesnutritionobesity Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2009-RG - Marie Curie Action: "Reintegration Grants" Zaproszenie do składania wniosków FP7-PEOPLE-2010-RG Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-ERG - European Re-integration Grants (ERG) Koordynator UNIVERSIDAD DE GRANADA Wkład UE € 45 000,00 Adres CUESTA DEL HOSPICIO SN 18071 Granada Hiszpania Zobacz na mapie Region Sur Andalucía Granada Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Miguel Angel Cabrerizo-Vilchez (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
