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Making People with Broken Bones Mobile again: EU-Funded Project cmRNAbone Releases Animated Clip

The European research project cmRNAbone has released a short, animated video clip. Now in its second project year, the cmRNAbone project is working to develop a novel regenerative therapy for people with large traumatic bone injuries or osteoporosis.

Health

The newly released video presents the project’s scientific research and objectives in an easy-to-understand and entertaining format in order to reach one of the project’s main target groups – a lay audience. The video is available on the project’s website at https://www.cmrnabone.eu/ and on YouTube under https://youtu.be/do4uxUrZcwc. Coordinated by the AO Research Institute Davos (Switzerland), the cmRNAbone project combines the innovation potential of SMEs with the market experience of research institutes and the international expertise of several renowned universities and university hospitals. The consortium strives to develop chemically modified RNAs and a specific vector delivery system to be embedded in a biomaterial formulation tailored to patients’ needs. The approach is a unique combination of genetic research, advanced nano- and biotechnology and 3D-printing. The new findings will be applied in two pre-clinical studies to demonstrate the validity of the designed gene therapy for osteoporotic and traumatic bone defects. The ultimate goal of the cmRNAbone project is the rapid translation of the novel therapy to the clinic. Over the last year, the cmRNAbone project has reached several milestones. Despite the implications of the COVID-19 pandemic and its effects on all areas of research, the project consortium has progressed towards reaching their goal. The basis for the scientific work has been laid, internal standards and procedures were established and the first scientific related deliverables exploring the influence of combined cmRNAs on regeneration processes in bone tissue repair and defining the features of the 3D printer have been submitted. To kick-start communication activities, a press release, dedicated articles and tweets about the project have been published and circulated through various communication channels.

Keywords

cmRNA, osteoporosis, 3D printing, bioprinting, bioink, gene therapy, bone trauma, bone graft