Sustainable Exploitation of bio-based Compounds Revealed and Engineered from naTural sources.

Rezultaty

Report on LCA and LCC: Baseline scope, functional units definition and database review

Baseline scope functional units definition and database review to assess both the environmental impacts and the capital operational costs and costs reductions of SECRETed innovative biotechnological value chain for biosurfactants and siderophores production

First report on phylogenetic tree database for siderophore and biosurfactant biosynthetic gene clusters and enzymes and their reactions.

Public available siderophore and biosurfactant biosynthetic gene clusters and enzymes and their reactions will be delivered after identifying Key Exploitable Results KERs which will be described later in the interim PEDR D82 in M18

Report on LCA and LCC: Screening test and first recommendations

Screening test and first recommendations to assess both the environmental impacts and the capital, operational costs and costs reductions of SECRETed innovative biotechnological value chain for biosurfactants and siderophores production.

Protocols Handbook for chemical characterization and preparatory techniques.

Besides previous approaches conducted by consortium members PHM SZN and MATIS will guide the preparation of standardized methods on sample processing and sharing This is crucial since samples from cultures clones or pool of clones and any extractsfractions containing traces of siderophore or surfactant activity need to be properly standardized to ensure the good progress of the project This will ultimately lead the development of a Handbook for chemical characterization and preparatory techniques D21 on month M6 and is closely related to deliverables envisaged in Tasks 5154 The Handbook will be revised and updated within WP5 activities

First report on SECRETed Molecular Networks: Publicly available molecular structures and inference of associated features to molecular fingerprints

Public available molecular structures and the inference of associated features to molecular fingerprints will be delivered after identifying Key Exploitable Results KERs which will be described later in the interim PEDR D82 in M18

Final report on phylogenetic tree database for siderophore and biosurfactant biosynthetic gene clusters containing novel enzymes and their reactions.

Public available siderophore and biosurfactant biosynthetic gene clusters and enzymes and their reactions will be delivered after identifying Key Exploitable Results KERs which will be described later in the interim PEDR D82 in M36

Protocols Handbook of screening procedures for extremophilic microorganisms

PHM ADL LUND MATIS USE and SZN will work together on the development of a standardized screening pipeline which will be applied to evaluate the potential of all the project microbial collections for the production of bioactive molecules This will allow the reproducibility of the results in the biodiscovery of new biosurfactants and siderophores A single deliverable D22 on month M6 will be achieved by reporting a Protocols Handbook of screening procedures for marine and extremophilic microorganisms

Final report on SECRETed Molecular Networks: New molecular structures and associated features to molecular fingerprints.

Public available molecular structures and the inference of associated features to molecular fingerprints will be delivered after identifying Key Exploitable Results KERs which will be described later in the interim PEDR D83 in M36

Project website and social media presence

The website will contain a brief presentation of the project goals and objectives along with a brief description of the consortium and the implemented work strategy It will serve as the major source of information for the public regarding updates achievements and activitiesAs a result the website will be continuously updated with any relevant updateSocial media accounts for the direct promotion of SECRETed will be set up These accounts will be active in both professional networks eg LinkedIn and publicsocial networks eg Facebook Twitter enabling the projects communication to be as broad as possible Active and continuous online presence can be ensured with the social media accounts providing direct measurements on the interested audience and its engagement rate

Publikacje

Integrated genome and metabolome mining unveiled structure and biosynthesis of novel lipopeptides from a deep‐sea <i>Rhodococcus</i>

Autorzy: Costanza Ragozzino, Fortunato Palma Esposito, Carmine Buonocore, Pietro Tedesco, Daniela Coppola, Davide Paccagnella, Nadine Ziemert, Gerardo Della Sala, Donatella de de Pascale
Opublikowane w: Microbial Biotechnology, Numer 17, 2024, ISSN 1751-7915
Wydawca: John Wiley & Sons Ltd
DOI: 10.1111/1751-7915.70011

Novel Insights into the Nobilamide Family from a Deep-Sea Bacillus: Chemical Diversity, Biosynthesis and Antimicrobial Activity Towards Multidrug-Resistant Bacteria

Autorzy: Vincenza Casella, Gerardo Della Sala, Silvia Scarpato, Carmine Buonocore, Costanza Ragozzino, Pietro Tedesco, Daniela Coppola, Giovanni Andrea Vitale, Donatella de Pascale, Fortunato Palma Esposito
Opublikowane w: Marine Drugs, Numer 23, 2025, Strona(/y) 41, ISSN 1660-3397
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md23010041

Medium development and production of carotenoids and exopolysaccharides by the extremophile Rhodothermus marinus DSM16675 in glucose-based defined media

Autorzy: Israt Jahan Mukti; Roya R. R. Sardari; Thordis Kristjansdottir; Gudmundur O. Hreggvidsson; Eva Nordberg Karlsson
Opublikowane w: Microbial Cell Factories, Numer 14752859, 2022, ISSN 1475-2859
Wydawca: BioMed Central
DOI: 10.1186/s12934-022-01946-7

Novel Insights on Pyoverdine: From Biosynthesis to Biotechnological Application

Autorzy: Filippo Dell'Anno; Giovanni Andrea Vitale; Carmine Buonocore; Laura Vitale; Fortunato Palma Esposito; Daniela Coppola; Gerardo Della Sala; Pietro Tedesco; Donatella de Pascale
Opublikowane w: International Journal of Molecular Sciences, Numer 14220067, 2022, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms231911507

Combining OSMAC Approach and Untargeted Metabolomics for the Identification of New Glycolipids with Potent Antiviral Activity Produced by a Marine Rhodococcus

Autorzy: Palma Esposito, Fortunato; Giugliano, Rosa; Della Sala, Gerardo; Vitale, Giovanni Andrea; Buonocore, Carmine; Ausuri, Janardhan; Galasso, Christian; Coppola, Daniela; Franci, Gianluigi; Galdiero, Massimiliano; de Pascale, Donatella
Opublikowane w: International Journal of Molecular Sciences, 2021, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22169055

Applicability of Control Materials To Support Gene Promoter Characterization and Expression in Engineered Cells Using Digital PCR

Autorzy: Ana Fernandez-Gonzalez; Simon Cowen; Juhyun Kim; Carole A. Foy; Jose Jimenez; Jim F. Huggett
Opublikowane w: Analytical Chemistry, 2022, ISSN 0003-2700
Wydawca: American Chemical Society
DOI: 10.1021/acs.analchem.1c05134

Gliotoxinmediated bacterial growth inhibition is caused by specific metal ion depletion

Autorzy: Shane G. Downes, Rebecca A. Owens, Kieran Walshe, David A. Fitzpatrick, Amber Dorey, Gary W. Jones, Sean Doyle
Opublikowane w: Scientific Reports, 2023, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-023-43300-w

New Imidazolium Alkaloids with Broad Spectrum of Action from the Marine Bacterium Shewanella aquimarina

Autorzy: Rosa Giugliano, Gerardo Della Sala, Carmine Buonocore, Carla Zannella, Pietro Tedesco, Fortunato Palma Esposito, Costanza Ragozzino, Annalisa Chianese, Maria Vittoria Morone, Valerio Mazzella4, Laura Nez-Pons, Veronica Folliero, Gianluigi Franci, Anna De Filippis, Massimiliano Galdiero1, Donatella de Pascale
Opublikowane w: Pharmaceutics, 2023, Strona(/y) 2139, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15082139

Evaluation of Antimicrobial Properties and Potential Applications of Pseudomonas gessardii M15 Rhamnolipids towards Multiresistant Staphylococcus aureus

Autorzy: Carmine Buonocore; Rosa Giugliano; Gerardo Della Sala; Fortunato Palma Esposito; Pietro Tedesco; Veronica FOLLIERO; Massimiliano Galdiero; Gianluigi Franci; Donatella de Pascale
Opublikowane w: Pharmaceutics, 2023, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15020700

Water potential governs the effector specificity of the transcriptional regulator XylR of Pseudomonas putida

Autorzy: Pavel Dvok; Teca Calcagno Galvo; Katharina Pflger-Grau; Alice M. Banks; Vctor de Lorenzo; Jose I. Jimnez
Opublikowane w: Environmental Microbiology, 2023, ISSN 1462-2920
Wydawca: Applied Microbiology International
DOI: 10.1111/1462-2920.16342

Production of selenium nanoparticles occurs through an interconnected pathway of sulphur metabolism and oxidative stress response in Pseudomonas putida KT2440

Autorzy: Roberto Avendao; Said MuozMontero; Diego RojasGtjens; Paola FuentesSchweizer; Sofa Vieto; Rafael Montenegro; Manuel Salvador; Rufus Frew; Juhyun Kim; Max Chavarra; Jose I. Jimnez
Opublikowane w: Microbial Biotechnology, 2023, ISSN 1751-7915
Wydawca: John Wiley & Sons Ltd
DOI: 10.1111/1751-7915.14215

Dihydroauroglaucin Isolated from the Mediterranean Sponge Grantia compressa Endophyte Marine Fungus Eurotium chevalieri Inhibits Migration of Human Neuroblastoma Cells

Autorzy: Marzia Vasarri, Giovanni Andrea Vitale, Giovanna Cristina Varese, Emanuela Barletta, Maria Valeria DAuria, Donatella de Pascale and Donatella DeglInnocenti
Opublikowane w: Pharmaceutics, 2022, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14030616

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

Autorzy: Mitja M Zdouc, Kai Blin, Nico L L Louwen, Jorge Navarro, Catarina Loureiro, Chantal D Bader, Constance B Bailey, Lena Barra, Thomas J Booth, Kenan A J Bozhüyük, José D D Cediel-Becerra, Zachary Charlop-Powers, Marc G Chevrette, Yit Heng Chooi, Paul M D’Agostino, Tristan de Rond, Elena Del Pup, Katherine R Duncan, Wenjia Gu, Novriyandi Hanif, Eric J N Helfrich, Matthew Jenner, Yoh
Opublikowane w: Nucleic Acids Research, Numer 53, 2025, Strona(/y) D678-D690, ISSN 0305-1048
Wydawca: Oxford University Press
DOI: 10.1093/nar/gkae1115

Antiviral Activity of the Rhamnolipids Mixture from the Antarctic Bacterium Pseudomonas gessardii M15 against Herpes Simplex Viruses and Coronaviruses

Autorzy: Giugliano Rosa; Buonocore Carmine; Zannella Carla; Chianese Annalisa; Esposito Fortunato Palma; Tedesco Pietro; De Filippis Anna; Galdiero Massimiliano; Franci Gianluigi; de Pascale Donatella
Opublikowane w: Pharmaceutics, 2021, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13122121

Prolonged Subculturing of Aspergillus fumigatus on Galleria Extract Agar Results in Altered Virulence and Sensitivity to Antifungal Agents

Autorzy: Aaron Curtis; KieranWalshe; Kevin Kavanagh
Opublikowane w: Cells, 2023, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells12071065

MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters

Autorzy: Barbara Terlouw; Kai Blin; Jorge C. Navarro-Muoz; Nicole E. Avalon; Marc Chevrette; Susan Egbert; Sanghoon Lee; David Meijer; Michael Recchia; Zachary L. Reitz; Jeffrey A. van Santen; Nelly Selem; Thomas Trring; Liana Zaroubi; Mohammad Alanjary; Gajender Aleti; Csar Aguilar; Suhad Al-Salihi; Hannah E. Augustijn; J. Abraham Avelar-Rivas; Luis Alfredo Avitia Dominguez; Barona-Gomez F; Jordan B
Opublikowane w: Nucleic Acids Research, 2023, ISSN 0305-1048
Wydawca: Oxford University Press
DOI: 10.1093/nar/gkac1049

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