Chemical synthesis has traditionally been a discipline that was part clever application of accumulated knowledge and part “art”. In recent years, a revolution has been gathering pace with the introduction of robotics, microfluidics, integrated analytics, and AI-based integration of data, leading to programmable synthesis of molecules using computer-controlled devices. This paradigm change opens up new opportunities to push chemistry beyond the synthesis of molecules to the synthesis of chemical reaction networks (CRNs), which in living organisms control all essential processes. CORENET aims at construct chemical systems that can perform high-level computation based on chemical reactions. The project will implement reservoir computing based on the compartmentalisation of reaction networks with increasing complexity in microfluidic flow reactors. The main advantage of CRNs for computing is that they are able to generate vast compositional chemical spaces, allowing them to process information and regulate their responses in a ‘metabolic’ way. The project will bring new knowledge bridging system chemistry, microfluidics technology and computational science and may revolutionize patient treatment via in situ synthesis of drug molecules.