FuEl ThE bRaiN In healtThY aging and agE-relateD diseases

Informacje na temat projektu

ETERNITY

Identyfikator umowy o grant: 101072759

DOI

10.3030/101072759

Data podpisania przez KE 6 Lipca 2022

Data rozpoczęcia 1 Lutego 2023

Data zakończenia 31 Stycznia 2027

Finansowanie w ramach

• Marie Skłodowska-Curie Actions (MSCA)

Koszt całkowity

Brak danych

Wkład UE

€ 2 629 260,00

Koordynowany przez

UNIVERSITA DEGLI STUDI DI MILANO
Italy

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Websites, patent fillings, videos etc. (1)

Creation of ETERNITY website.

Publikacje

Peer reviewed articles (29)

Neuronal glycolysis meets mitophagy to govern organismal wellbeing

Autorzy: Daniel Jimenez-Blasco, Rebeca Lapresa, Jesus Agulla, Angeles Almeida, Juan P. Bolaños
Opublikowane w: Trends in Endocrinology & Metabolism, Numer 37, 2026, ISSN 1043-2760
Wydawca: Elsevier BV
DOI: 10.1016/J.TEM.2025.05.005

Targeting senescent cells with NKG2D-CAR T cells

Autorzy: Yushuang Deng, Avadh Kumar, Kan Xie, Kristina Schaaf, Enzo Scifo, Sarah Morsy, Tao Li, Armin Ehninger, Daniele Bano and Dan Ehninger
Opublikowane w: Cell Death Discovery, ISSN 2058-7716
Wydawca: Springer Nature
DOI: 10.1038/S41420-024-01976-7

A lactate-dependent shift of glycolysis mediates synaptic and cognitive processes in male mice

Autorzy: Ignacio Fernández-Moncada; Gianluca Lavanco; Unai B. Fundazuri; Nasrin Bollmohr; Sarah Mountadem; Tommaso Dalla Tor; Pauline Hachaguer; Francisca Julio-Kalajzic; Doriane Gisquet; Roman Serrat; Luigi Bellocchio; Astrid Cannich; Bérénice Fortunato-Marsol; Yusuke Nasu; Robert E. Campbell; Filippo Drago; Carla Cannizzaro; Guillaume Ferreira; Anne-Karine Bouzier-Sore; Luc Pellerin; Juan P. Bolaños; Gilles Bonvento; L. Felipe Barros; Stephane H. R. Oliet; Aude Panatier; Giovanni Marsicano
Opublikowane w: Nature Communications, 2024, ISSN 1476-4687
Wydawca: Springer Nature
DOI: 10.1038/s41467-024-51008-2

Potentiation of mitochondrial function by mitoDREADD-Gs reverses pharmacological and neurodegenerative cognitive impairment in mice

Autorzy: Antonio C. Pagano Zottola, Rebeca Martín-Jiménez, Gianluca Lavanco, Geneviève Hamel-Côté, Carla Ramon-Duaso, Rui S. Rodrigues, Yamuna Mariani, Mehtab Khan, Filippo Drago, Stephanie Jean, Itziar Bonilla-Del Río, Daniel Jimenez-Blasco, Jon Egaña-Huguet, Abel Eraso-Pichot, Sandra Beriain, Astrid Cannich, Laura Vidal-Palencia, Rosmara Infantino, Francisca Julio-Kalajzić, Doriane Gisquet, Ania Goncalves, Inas Al-Younis, Yann Baussan, Stephane Duvezin-Caubet, Anne Devin, Edgar Soria-Gomez, Nagore Puente, Juan P. Bolaños, Pedro Grandes, Sandrine Pouvreau, Arnau Busquets-Garcia, Giovanni Marsicano, Luigi Bellocchio, Etienne Hebert-Chatelain
Opublikowane w: Nature Neuroscience, Numer 28, 2025, ISSN 1097-6256
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S41593-025-02032-Y

HTZ-1/H2A.Z expression sustains transcriptional programs that regulate Caenorhabditis elegans lifespan

Autorzy: Beijia Xie, Enzo Scifo, Ioanna-Maria Menegatou, Rossella Erminia Ciliberti, Mrityunjoy Mondal, Yiru Wang, Antonia Piazzesi, Jialu Hu, Elena De Domenico, Stefan Paulusch, Diego De Stefani, Matthias Schmid, Dagmar Wachten, Marc D. Beyer, Pierluigi Nicotera, Nasir Ahmad Aziz, Dan Ehninger, Daniele Bano
Opublikowane w: Mechanisms of Ageing and Development, Numer 232, 2026, ISSN 0047-6374
Wydawca: Elsevier BV
DOI: 10.1016/J.MAD.2026.112217

Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice

Autorzy: Sarah Morsy, Enzo Scifo, Kan Xie, Kristina Schaaf, Jenny Russ, Stefan Paulusch, Elena De Domenico, Paolo Salomoni, Daniele Bano, Dan Ehninger
Opublikowane w: Aging Cell, Numer 25, 2026, ISSN 1474-9718
Wydawca: Wiley
DOI: 10.1111/ACEL.70357

D-lactate and glycerol as potential biomarkers of sorafenib activity in hepatocellular carcinoma

Autorzy: Silvia Pedretti, Francesca Palermo, Miriana Braghin, Gabriele Imperato, Pasquale Tomaiuolo, Meral Celikag, Marta Boccazzi, Veronica Vallelonga, Lorenzo Da Dalt, Giuseppe Danilo Norata, Giorgia Marisi, Ilario Giovanni Rapposelli, Andrea Casadei-Gardini, Serena Ghisletti, Maurizio Crestani, Emma De Fabiani, Nico Mitro
Opublikowane w: Signal Transduction and Targeted Therapy, Numer 10, 2025, ISSN 2059-3635
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S41392-025-02282-Z

Glucose-derived glutamate drives neuronal terminal differentiation in vitro

Autorzy: D'Andrea, Laura; Audano, Matteo; Pedretti, Silvia; Pelucchi, Silvia; Stringhi, Ramona; Imperato, Gabriele; De Cesare, Giulia; Cambria, Clara; Laporte, Marine H; Zamboni, Nicola; Antonucci, Flavia; Di Luca, Monica; Mitro, Nico; Marcello, Elena
Opublikowane w: EMBO Reports, 2024
Wydawca: PUBMED
DOI: 10.1038/S44319-023-00048-8

Analysis of the senescence‐associated cell surfaceome reveals potential senotherapeutic targets

Autorzy: Yushuang Deng, Ting Liu, Enzo Scifo, Tao Li, Kan Xie, Bernd Taschler, Sarah Morsy, Kristina Schaaf, Armin Ehninger, Daniele Bano, Dan Ehninger
Opublikowane w: Aging Cell, 2024, ISSN 1474-9718
Wydawca: Wiley
DOI: 10.1111/acel.14312

Rethinking the role of microglia in obesity

Autorzy: Giulia Cutugno, Evangelia Kyriakidou, Agnes Nadjar
Opublikowane w: Neuropharmacology, ISSN 1873-7064
Wydawca: Elsevier Ltd.
DOI: 10.1016/J.NEUROPHARM.2024.109951

Single cell whole-genome sequencing of brain cells: age- and cell-type specific mutational profiles

Autorzy: Melania Capasso; N. Ahmad Aziz
Opublikowane w: Signal Transduction and Targeted Therapy, 2024, ISSN 1476-4687
Wydawca: Springer Nature
DOI: 10.1038/s41392-024-01892-3

Microglia activation by derepression of endogenous retroviruses drives inflammation and cellular senescence

Autorzy: Xin Yan, Christina Georgopoulou, Hang-Mao Lee, Ala Ahrari, Jenny Russ, Vijay Chandrasekar, Tim Ducksch, Giuliano Crispatzu, Valentina Talevi, Liang Qiao, Shobhit Agrawal, Sophie Crux, Andrew W. Daman, Lena Wischhof, Miriam Stork, Margit Zweyer, Emma Dorotea Zanfi, Manon Chevallot-Beroux, Yunxiao Li, Elena De-Domenico, Dina Hüsson, Lorenzo Bonaguro, Yuanfang Li, Jonas Schulte-Schrepping, Qingyi Liang, Ketty Kessler, Dan Ehninger, Shahin Rafii, Jiankai Luo, Andreas Hermann, Annett Halle, Ying Liu, Elvira Mass, Melania Capasso, Hiroki Kato, Joachim L. Schultze, Pierluigi Nicotera, Daniele Bano, Steven Zvi Josefowicz, Martin Fuhrmann, Thomas Ulas, Marc Beyer, Juntang Lin, Monique M. B. Breteler, N. Ahmad Aziz, Paolo Salomoni
Opublikowane w: Nature Neuroscience, 2026, ISSN 1097-6256
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S41593-026-02404-Y

Potent, selective and reversible hMAO-B inhibition by benzalphthalides: Synthesis, enzymatic and cellular evaluations and virtual docking and predictive studies

Autorzy: Esther del Olmo; Bianca Barboza; Maria Delgado-Esteban; Nerea Escala; Daniel Jiménez-Blasco; José L. Lopez-Pérez; Laura Cillero de la Fuente; Elías Quezada; Javier Munín; Dolores Viña; Juan P. Bolaños; Arturo San Feliciano
Opublikowane w: Bioorganic Chemistry, 2024
Wydawca: ELSEVIER
DOI: 10.1016/J.BIOORG.2024.107255

Endogenous mitochondrial hydrogen peroxide regulates neurogenesis during cortical development

Autorzy: Regina Mengual, Verónica Bobo-Jiménez, Cristina Rodríguez, Rebeca Lapresa, Darío García-Rodríguez, Daniel Jiménez-Blasco, Elisa Cabiscol, Joaquim Ros, María Delgado-Esteban, Juan P. Bolaños, null Ángeles Almeida
Opublikowane w: Redox Biology, Numer 88, 2026, ISSN 2213-2317
Wydawca: Elsevier BV
DOI: 10.1016/J.REDOX.2025.103940

Long-term rapamycin treatment suppresses IL-17-producing gamma delta T cells and blunts neuroinflammation in aging

Autorzy: Clement Torrent, Caterina Gagliardi, Nina Fülle, Ignazio Antignano, Maria Eugenia Bernis, Miriam Stork, Daniele Bano, Melania Capasso, Lily Keane
Opublikowane w: PLOS One, Numer 21, 2026, ISSN 1932-6203
Wydawca: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PONE.0343183

Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin

Autorzy: Kan Xie, Chengfeng Wang, Enzo Scifo, Brandon Pearson, Devon Ryan, Kristin Henzel, Astrid Markert, Kristina Schaaf, Xue Mi, Xin Tian, Jiajia Jia, Meiqin Wang, Stefan Bonn, Manuel Schölling, Christoph Möhl, Daniele Bano, Yu Zhou, Dan Ehninger
Opublikowane w: Cell Metabolism, Numer 37, 2025, ISSN 1550-4131
Wydawca: Elsevier BV
DOI: 10.1016/J.CMET.2025.03.001

Brightness and shadows of mitochondrial ROS in the brain

Autorzy: Daniel Jimenez-Blasco, Angeles Almeida, Juan P. Bolaños
Opublikowane w: Neurobiology of Disease, Numer 184, 2024, ISSN 0969-9961
Wydawca: Elsevier BV
DOI: 10.1016/J.NBD.2023.106199

Proteomic aging signatures across mouse organs and life stages

Autorzy: Enzo Scifo, Sarah Morsy, Ting Liu, Kan Xie, Kristina Schaaf, Daniele Bano, Dan Ehninger
Opublikowane w: The EMBO Journal, Numer 44, 2026, ISSN 0261-4189
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S44318-025-00509-X

Signaling roles for astrocytic lipid metabolism in brain function

Autorzy: Juan P Bolaños, Angeles Almeida
Opublikowane w: EMBO Reports, Numer 27, 2026, ISSN 1469-3178
Wydawca: Springer Nature
DOI: 10.1038/S44319-025-00683-3

Dietary lipid content modifies wah-1/AIFM1-associated phenotypes via LRK-1 and DRP-1 expression in C. elegans

Autorzy: Mrityunjoy Mondal, Enzo Scifo, Rossella Erminia Ciliberti, Lena Wischhof, Tannaz Norizadeh Abbariki, Joshua Jackson, Ioanna-Maria Menegatou, Viktoria Zeisler-Diehl, Jan Riemer, Benjamin Jussila, Christopher E. Hopkins, Sylwia Kierszniowska, Lukas Schreiber, Pierluigi Nicotera, Dan Ehninger, Daniele Bano
Opublikowane w: Nature Communications, Numer 16, 2025, ISSN 2041-1723
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-66900-8

Mitochondrial complex I inhibition enhances astrocyte responsiveness to pro-inflammatory stimuli

Autorzy: Wischhof, Lena; John Mathew, Amal; Bonaguro, Lorenzo; Beyer, Marc; Ehninger, Dan; Nicotera, Pierluigi; Bano, Daniele
Opublikowane w: Scientific Reports, 2024
Wydawca: NATURE
DOI: 10.1038/S41598-024-78434-Y

Individual differences in prosocial learning are represented in the hippocampal dorsal CA1

Autorzy: Filippo La Greca, Elisa Zianni, Ilaria Cerchiaro, Michela Gusmini, Giulia Coccia, Alexandre Carrea, Silvia Pelucchi, Carlo Castoldi, Davide Maggioni, Elena Marcello, Bianca Ambrogina Silva, Fabrizio Gardoni, Monica DiLuca, Diego Scheggia
Opublikowane w: Nature Neuroscience, Numer 29, 2026, ISSN 1097-6256
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S41593-026-02292-2

Potent, selective and reversible hMAO-B inhibition by benzalphthalides: Synthesis, enzymatic and cellular evaluations and virtual docking and predictive studies

Autorzy: Esther del Olmo, Bianca Barboza, Maria Delgado-Esteban, Nerea Escala, Daniel Jiménez-Blasco, José L. Lopez-Pérez, Laura Cillero de la Fuente, Elías Quezada, Javier Munín, Dolores Viña, Juan P. Bolaños, Arturo San Feliciano
Opublikowane w: Bioorganic Chemistry, Numer 146, 2025, ISSN 0045-2068
Wydawca: Elsevier BV
DOI: 10.1016/J.BIOORG.2024.107255

Transcriptomic and metabolic signatures of neural cells cultured under a physiologic-like environment

Autorzy: Emilio Fernandez, Moussa Warde, Israel Manjarres-Raza, Veronica Bobo-Jimenez, Maria Martinez-Luna, Carlos Vicente-Gutierrez, Dario Garcia-Rodriguez, Daniel Jimenez-Blasco, Angeles Almeida, Juan P. Bolaños
Opublikowane w: Journal of Biological Chemistry, Numer 300, 2026, ISSN 0021-9258
Wydawca: Elsevier BV
DOI: 10.1016/J.JBC.2024.107937

Interaction with AK2A links AIFM1 to cellular energy metabolism

Autorzy: Robin Alexander Rothemann, Egor Pavlenko, Mrityunjoy Mondal, Sarah Gerlich, Pavel Grobushkin, Sebastian Mostert, Julia Racho, Konstantin Weiss, Dylan Stobbe, Katharina Stillger, Kim Lapacz, Silja Lucia Salscheider, Carmelina Petrungaro, Dan Ehninger, Thi Hoang Duong Nguyen, Jörn Dengjel, Ines Neundorf, Daniele Bano, Simon Poepsel, Jan Riemer
Opublikowane w: Molecular Cell, Numer 85, 2026, ISSN 1097-2765
Wydawca: Elsevier BV
DOI: 10.1016/J.MOLCEL.2025.05.036

Weak neuronal glycolysis sustains cognition and organismal fitness

Autorzy: D Jimenez-Blasco, J Agulla, R Lapresa, M Garcia-Macia, V Bobo-Jimenez, D Garcia-Rodriguez, I Manjarres-Raza, E Fernandez, Y Jeanson, S Khoury, JC Portais, D Padro, Ramos-Cabrer, P Carmeliet, A Almeida & JP Bolaños
Opublikowane w: Nature Metabolism, ISSN 2522-5812
Wydawca: Springer Nature
DOI: 10.1038/S42255-024-01049-0

BCL-11 enables adaptive stress responses to environmental challenges

Autorzy: Patrizia Niedworok, Rossella Erminia Ciliberti, Beijia Xie, Amal John Mathew, Benjamin Jussila, Jennifer A. Lawson, Elena De Domenico, Stefan Paulusch, Marc Beyer, Pierluigi Nicotera, N. Ahmad Aziz, Dan Ehninger, Sandra Blaess, Daniele Bano
Opublikowane w: iScience, Numer 29, 2026, ISSN 2589-0042
Wydawca: Elsevier BV
DOI: 10.1016/J.ISCI.2025.114422

TET3 regulates terminal cell differentiation at the metabolic level

Autorzy: Isabel Mulet; Carmen Grueso-Cortina; Mireia Cortés-Cano; Daniela Gerovska; Guangming Wu; Stefania Alexandra Iakab; Daniel Jimenez-Blasco; Andrea Curtabbi; Pablo Hernansanz-Agustín; Harmony Ketchum; Israel Manjarrés-Raza; F. Thomas Wunderlich; Juan Pedro Bolaños; Meelad M. Dawlaty; Carsten Hopf; José Antonio Enríquez; Marcos J. Araúzo-Bravo; Natalia Tapia
Opublikowane w: Nature Communications, 2024
Wydawca: NATURE COMMUNICATIONS
DOI: 10.1038/S41467-024-54044-0

TMEM65-dependent Ca2+ extrusion safeguards mitochondrial homeostasis

Autorzy: Massimo Vetralla, Lena Wischhof, Asrat Kahsay, Vanessa Cadenelli, Enzo Scifo, Beijia Xie, Miriana Sbrissa, Maëlle Sandhira Habert, Dan Ehninger, Rosario Rizzuto, Daniele Bano, Diego De Stefani
Opublikowane w: Nature Communications, Numer 17, 2026, ISSN 2041-1723
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-67647-Y