Cel
The QuIC-ConCePT consortium has 2 objectives:
1.(90% of resource, WP2-5) to qualify 3 specific imaging biomarkers (IBs) of tumour cell proliferation, apoptosis, and necrosis, to allow drug developers to demonstrate reliably modulation of these pathologic processes in tumours in patients in realistic trials. Our vision for January 2016 is that drug developers can incorporate these IBs for decision-making in Phase I trials of investigational therapies, confident that the IBs are technically valid, that a measured change in the IB faithfully reflects the desired change in the underlying tumour pathology, and that the IBs can be readily deployed in multiple cancer centres in a robust, consistent, ethical, and cost-effective way acceptable to patients.
2.(10% of resource, WP6) includes a portfolio of innovative approaches to devise, evaluate and introduce IBs of invasion and metastasis.
The IBs of tumour cell proliferation and necrosis will be developed respectively from FLT PET and ADC MRI respectively. Initial apoptosis plans focus on ICMT11 PET, possibly with other IBs introduced later. The project will be delivered using a portfolio of animal (WP2), human (WP3), image analysis (WP4) and regulatory (WP5) work. The project will be coordinated and the interdependent workpackages integrated in WP1. These WPs will deliver image acquisition and analysis protocols which are technically valid, standardised and suitable for multicentre use. We will evaluate reproducibility, effects of intervention, timing, dose-response, and imaging-histopathology correlation in animals and patients. The project is timely, and highly likely to deliver IBs which will markedly improve drug development, and benefit cancer patients in Europe and globally. The managing entity (EORTC) is already world-leading in the qualification of IBs, and the consortium includes in the academic and EFPIA partners some of the world's most productive and innovative physicians and scientists in cancer imaging.
Dziedzina nauki
Zaproszenie do składania wniosków
IMI-JU-02-2009
Zobacz inne projekty w ramach tego zaproszenia
System finansowania
JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)Koordynator
1200 Bruxelles / Brussel
Belgia
Zobacz na mapie
Uczestnicy (23)
151 85 Sodertaelje
Zobacz na mapie
Zakończenie uczestnictwa
E20 1JQ LONDON
Zobacz na mapie
M13 9PL Manchester
Zobacz na mapie
48149 MUENSTER
Zobacz na mapie
6525 XZ Nijmegen
Zobacz na mapie
75654 Paris
Zobacz na mapie
6229 ET Maastricht
Zobacz na mapie
1081 HV Amsterdam
Zobacz na mapie
WC2R 2LS London
Zobacz na mapie
2650 Edegem
Zobacz na mapie
SW7 3RP London
Zobacz na mapie
3015 GD Rotterdam
Zobacz na mapie
SW7 2AZ LONDON
Zobacz na mapie
44815 Saint-Herblain
Zobacz na mapie
8092 Zuerich
Zobacz na mapie
1831 Diegem
Zobacz na mapie
RG21 4FA Basingstoke
Zobacz na mapie
TW89GS Brentford
Zobacz na mapie
64293 Darmstadt
Zobacz na mapie
CT13 9NJ Sandwich
Zobacz na mapie
4070 Basel
Zobacz na mapie
94250 GENTILLY
Zobacz na mapie
CB2 1TN Cambridge
Zobacz na mapie