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Pemphigus - From autoimmunity to disease

Cel

Pemphigus is a potentially lethal bullous disease of the skin and mucosa and may be considered as a paradigmatic organ-specific autoimmune disease due to 1) its well-defined autoantigens, 2) the knowledge of critical events of its immune pathogenesis and 3) the reproducibility of major clinical and pathogenic features in suitable animal models. Overall, understanding the etiopathogenesis of pemphigus may provide crucial additional insight into basic mechanisms leading from autoimmunity to autoimmune disease and may help to design more specific therapeutic strategies. Despite the enormous progress, no specific therapy is currently available in pemphigus. The present project arises as a joined effort of European Scientists and Clinicians to establish a Consortium of groups engaged in providing a critical mass of patients and research tools to address the following goals: 1) to better define the immune pathogenesis of pemphigus utilizing two in vivo models of pemphigus with emphasis on autoaggressive T cells and their collaboration with autoantibody (autoAb) secreting B cells. 2) analysis of the autoAb-driven effector phase frequently involving “epitope spreading” which ultimately leads to a more severe disease; 3) characterization of the molecular events following Ab binding to the target autoantigens by defining autoAb-induced signalling events in epidermal keratinocytes; 4) spectrum of the autoimmune B cell response and the impact of therapeutic strategies on the cellular and humoral autoimmune response in pemphigus utilizing human monoclonal Ab which will be analysed for their fine specificity and genetically and functionally characterized; and 5) clinical read-out parameters for prospective studies which are urgently needed as valid parameters for the extent and activity of disease and which will be compared to serological markers and life quality assessment in pemphigus.

Zaproszenie do składania wniosków

FP7-HEALTH-2007-A
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Koordynator

PHILIPPS UNIVERSITAET MARBURG
Adres
Biegenstrasse 10
35037 Marburg
Niemcy

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Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Michael Hertl (Prof.)
Wkład UE
€ 492 000

Uczestnicy (6)

PROVINCIA ITALIANA DELLA CONGREGAZIONE DEI FIGLI DELLA IMMACOLATA CONCEZIONE
Włochy
Wkład UE
€ 377 400
Adres
Via Della Luce 46
00153 Roma

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Rodzaj działalności
Research Organisations
Kontakt administracyjny
Giovanna Zambruno (Dr.)
UNIVERSITAETSKLINIKUM FREIBURG
Niemcy
Wkład UE
€ 278 000
Adres
Hugstetter Strasse 49
79106 Freiburg

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Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Jürgen Dreyer
UNIVERSITAET BERN
Szwajcaria
Wkład UE
€ 814 000
Adres
Hochschulstrasse 6
3012 Bern

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Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Eliane Müller (Prof.)
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Niemcy
Wkład UE
€ 290 000
Adres
Geschwister-scholl-platz
72074 Tuebingen

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Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Martin Röcken (Prof.)
UNIVERSITE DE ROUEN NORMANDIE
Francja
Wkład UE
€ 260 000
Adres
Rue Thomas Becket 1 Mont Saint Aignan
76821 Mont Saint Aignan Cedex

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Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Nathalie Leschelle (Dr.)
FONDAZIONE PER L'ISTITUTO DI RICERCA IN BIOMEDICINA
Szwajcaria
Wkład UE
€ 308 000
Adres
Via Francesco Chiesa 5
6500 Bellinzona

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Rodzaj działalności
Research Organisations
Kontakt administracyjny
Fosca Bognuda (Ms.)