Obiettivo
A Europe-wide consortium of experimental biologists, biomathematicians, biostatisticians, computer scientists and clinical scientists will team up to approach cell death pathways in health and disease, placing particular emphasis on cancer and AIDS. The consortium will create a unique database integrating existing and accumulating knowledge on lethal signal transduction pathways leading to apoptosis or non-apoptotic (necrotic, autophagic, mitotic) cell death, perform data mining to integrate system-wide analyses on cell death (genome, epigenome, transcriptome, proteome, lipidome data), and use high-throughput methods (“omics”, CHiP-chip and genome-wide siRNA screens) for the experimental exploration of death pathways in human cell lines in vitro and in relevant disease models (in vitro in human cells and in vivo in mice and Drosophila). In addition, the consortium will establish mathematical models of lethal pathways to devise algorithms that predict apoptosis susceptibility and resistance, obtain data (genome, transcriptome, proteome, lipidome) on clinical samples (cancer cell lines, cancer tissues, serum, and blood samples) and perform biostatistical analyses on them in order to demonstrate the contribution of apoptotic process in human cancers and AIDS. Then, the consortium will integrate the knowledge into mathematical models for the optimal interpretation of clinical data, aiming at optimal diagnostic and prognostic performance as well as at the identification of possible therapeutic targets for the treatment of cancer and AIDS.
Campo scientifico
Parole chiave
Invito a presentare proposte
FP7-HEALTH-2007-A
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Meccanismo di finanziamento
CP-IP - Large-scale integrating projectCoordinatore
17177 Stockholm
Svezia
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Partecipanti (23)
75654 Paris
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75231 Paris
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00149 Roma
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9052 ZWIJNAARDE - GENT
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Partecipazione conclusa
89081 Ulm
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1015 LAUSANNE
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2100 Koebenhavn
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67404 Illkirch Graffenstaden
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7610001 Rehovot
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02044 VTT ESPOO
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69120 Heidelberg
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69117 Heidelberg
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69978 Tel Aviv
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80539 Munchen
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1030 Wien
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5230 Odense M
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2 Dublin
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8010 Graz
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69622 Villeurbanne Cedex
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81100 Caserta
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Partecipazione conclusa
00290 HELSINKI
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60596 Frankfurt Am Main
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13284 Marseille
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