European Commission logo
polski polski
CORDIS - Wyniki badań wspieranych przez UE
CORDIS
Zawartość zarchiwizowana w dniu 2024-06-18

Promotion of plasticity as a treatment for neurodegenerative conditions

Cel

Neurodegenerative diseases all cause damage to the circuitry of the nervous system, with loss of connections, axons and neurons. The loss can be gradual, as in Alzheimer’s disease, rapid as in stroke, or intermediate as in the delayed neuronal loss after stroke. Following damage, the nervous system is able partially to compensate through the formation of alternative connections and pathways, a process known as plasticity. Adults are therefore able to regain considerable function after stroke, and to compensate for the synapse and cell loss of Alzheimer’s disease until it reaches a critical level. Children undergo a period of enhanced plasticity in most parts of the CNS at the end of development, known as critical periods. During these periods their ability to compensate for damage to the CNS is in many cases much greater than in adults. The overall concept behind this application is that restoration of the function in neurodegeneration can be achieved through plasticity (the formation of new functional connections, withdrawal of inappropriate connections, modulation of synaptic strength). Promoting increased plasticity in selected parts of the adult nervous system back to the level seen in children is a powerful method of enhancing recovery of function in animal models. Plasticity-promoting treatments could therefore be beneficial in a wide range of conditions that damage the CNS. The PLASTICISE project integrates scientists from four scientific areas 1) Development of methods to promote plasticity 2) Development of models of neurodegenerative disease 3) Imaging of plasticity at the macro and micro level 4) Study of recovery of function through plasticity in human patients with brain disorders. The concept that unites the partners is the belief that treatments that enhance plasticity will become one of key medications that will improve neurological function in the damaged human nervous system. The purpose of the project is to bring this moment closer.

Dziedzina nauki

Słowa kluczowe

Program(-y)

Temat(-y)

Zaproszenie do składania wniosków

FP7-HEALTH-2007-B
Zobacz inne projekty w ramach tego zaproszenia

System finansowania

CP-FP - Small or medium-scale focused research project

Koordynator

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Wkład UE
€ 871 931,92
Adres
TRINITY LANE THE OLD SCHOOLS
CB2 1TN Cambridge
Zjednoczone Królestwo

Zobacz na mapie
Region
East of England East Anglia Cambridgeshire CC
Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Renata Schaeffer (Ms.)
Linki
Koszt całkowity
Brak danych

Uczestnicy (15)

Udostępnij tę stronę

Pobierz

Ostatnia aktualizacja: 16 Lipca 2019

Moja broszura

Permalink: https://cordis.europa.eu/project/id/223524/pl

European Union, 2024