Cel Recent data suggest the placebo effect to be a powerful demonstration of how mental activity that is shaped by expectation and experience can influence physiological functions. The current strategy to minimize potential placebo effects largely ignores the positive effects of the placebo response. The current proposal postulates a radically different approach: Instead of considering placebo effects a nuisance, we will explicitly investigate the mechanisms behind expectation and experience (i.e. placebo response) to develop its use for the benefit of the patient. Importantly, the same applies to the effect of negative expectations (i.e. nocebo response) that can be responsible for negative effects of treatment. Understanding the mechanisms and circumstances that promote these effects will allow us to adjust medical treatments to minimize these nocebo effects. We will investigate the mechanisms of placebo and nocebo responses in traditional fields such as pain, but also in respiratory medicine and in “cognitive enhancement”. Using functional magnetic resonance imaging (fMRI), pharmacological interventions and formal models we will in particular address the neuronal mechanisms underlying placebo and nocebo responses. Combining the data from all three fields (pain, respiration and cognitive enhancement) will allow us to identify domain general and domain specific mechanisms of placebo responses. These projects will be supported by a methodological work-package which will provide neuroimaging techniques to improve the assessment of placebo and nocebo relevant brain structures. Finally a large cohort of volunteers will be investigated, to assess the relationship between placebo responses, personality variables and genetic polymorphisms using a genome-wide association analysis. Insights gained in this project could have the potential to formally place placebo responses and related mechanisms such as experience and expectation into the mainstream of evidence based medicine. Dziedzina nauki medical and health sciencesclinical medicinepneumologyengineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imaging Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-AG-SH4 - ERC Advanced Grant - The Human Mind and its complexity Zaproszenie do składania wniosków ERC-2010-AdG_20100407 Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-AG - ERC Advanced Grant Instytucja przyjmująca UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF Wkład UE € 2 499 120,00 Adres Martinistrasse 52 20251 Hamburg Niemcy Zobacz na mapie Region Hamburg Hamburg Hamburg Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Heike Path (Ms.) Kierownik naukowy Christian Reiner Buechel (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (1) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF Niemcy Wkład UE € 2 499 120,00 Adres Martinistrasse 52 20251 Hamburg Zobacz na mapie Region Hamburg Hamburg Hamburg Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Heike Path (Ms.) Kierownik naukowy Christian Reiner Buechel (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
