Cel Motor behaviour requires the meaningful integration of a multitude of sensory information. The basal ganglia are essential for such sensory-motor processing and underlie motor planning, performance, and learning. The striatum is the input layer of the basal ganglia, acting as a “hub” that receives synaptic inputs from different brain regions, interacting primarily with the GABAergic striatal microcircuit. Sensory excitatory inputs to striatum arise from the thalamus and neocortex, targeting striatal projection neurons and interneurons.Previous work in basal ganglia focused mainly on their role in motor and reward related functions, but the functional role of striatum in sensory processing is largely unknown. In this study I will elucidate the principles of sensory processing performed at the striatal microcircuit. In particular, I aim to answer these fundamental questions:- How do striatal neurons integrate sensory input? How is sensory input from different sensory modalities integrated in the striatum? How are ipsi- and contralateral inputs integrated?- What are the respective roles of cortical and thalamic sensory inputs in striatal function?- How is the intra-striatal microcircuitry organized to support sensory integration?To address these questions I will use a combination of electrophysiological, optical, and anatomical methods, including:- In vivo whole-cell recordings from striatal neurons during visual and tactile stimulation.- Multi-neuron whole-cell recordings in corticostriatal and thalamostriatal slices.- Optical manipulation of identified neuronal subpopulations in slice and in vivo.The proposed study will provide a new understanding of sensory processing at the level of basal ganglia and may provide insights regarding basal ganglia dysfunction. Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-SG-LS5 - ERC Starting Grant - Neurosciences and neural disorders Zaproszenie do składania wniosków ERC-2011-StG_20101109 Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-SG - ERC Starting Grant Instytucja przyjmująca KAROLINSKA INSTITUTET Wkład UE € 1 494 445,00 Adres Nobels Vag 5 17177 Stockholm Szwecja Zobacz na mapie Region Östra Sverige Stockholm Stockholms län Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny åsa Garmager (Ms.) Kierownik naukowy Gilad Daniel Silberberg (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (1) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko KAROLINSKA INSTITUTET Szwecja Wkład UE € 1 494 445,00 Adres Nobels Vag 5 17177 Stockholm Zobacz na mapie Region Östra Sverige Stockholm Stockholms län Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny åsa Garmager (Ms.) Kierownik naukowy Gilad Daniel Silberberg (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych