Cel Psychotic disorders are amongst the most severe mental disorders. However, current treatments have failed to reduce disability or change the prospects for recovery for patients with a psychotic disorder. In this project, I will investigate an entirely novel therapy, targeting the core vulnerability profile of altered person-environment interactions underlying psychosis, specifically increased stress-reactivity and reduced motivated and goal-directed behaviour. My colleagues and I have developed a digital apparatus, the ‘PsyMate’, allowing real-time interventions for patients with severe mental illness. In this project, the PsyMate will be used to (1)reduce psychotic and emotional reactivity to stress with “detachment and acceptance” exercises in real life situations, and (2)improve motivated and goal-directed behaviour with real-time behavioural activation therapy. In a randomized controlled trial, I will investigate whether this self-management therapy, conducted outside the office in the patient’s real life, is capable of reducing psychotic reactivity to stress and of improving motivated behaviour in participants with an at-risk mental state for psychosis.In order to understand the impact of this intervention in terms of brain plasticity and prediction of response, I will use an experimental medicine approach to investigate the neural effects of the intervention. I will focus particularly on prefrontal dopamine-reactivity as the brain mechanism mediating altered person-environment interactions. In the current study, I will examine prefrontal dopamine reactivity towards positive as well as stressful negative events as the biological process mediating underlying motivated behaviour and environmental reactivity. Furthermore, I will investigate whether a self-management therapy specifically focused at aberrant person-environment interactions alters brain plasticity at the level of prefrontal dopaminergic neurotransmission in persons at risk for psychosis. Dziedzina nauki medical and health sciencesclinical medicinepsychiatry Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-SG-LS7 - Applied life sciences, biotechnology and bioengineering: agricultural, animal, fishery, forestry/food sciences; biotechnology, chemical biology, genetic engineering, synthetic biology, industrial biosciences; environmental biotechnology. Zaproszenie do składania wniosków ERC-2012-StG_20111109 Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-SG - ERC Starting Grant Instytucja przyjmująca KATHOLIEKE UNIVERSITEIT LEUVEN Wkład UE € 724 682,69 Adres OUDE MARKT 13 3000 Leuven Belgia Zobacz na mapie Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Stijn Delaure (Dr.) Kierownik naukowy Inez Yvonne Ronald Germeys (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (3) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko KATHOLIEKE UNIVERSITEIT LEUVEN Belgia Wkład UE € 724 682,69 Adres OUDE MARKT 13 3000 Leuven Zobacz na mapie Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Stijn Delaure (Dr.) Kierownik naukowy Inez Yvonne Ronald Germeys (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITAETSKLINIKUM AACHEN Zakończenie uczestnictwa Niemcy Wkład UE € 161 686,18 Adres Pauwelsstrasse 30 52074 Aachen Zobacz na mapie Region Nordrhein-Westfalen Köln Städteregion Aachen Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Volker Legewie (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITEIT MAASTRICHT Zakończenie uczestnictwa Niderlandy Wkład UE € 612 527,13 Adres MINDERBROEDERSBERG 4 6200 MD Maastricht Zobacz na mapie Region Zuid-Nederland Limburg (NL) Zuid-Limburg Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Laurent Louwies (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych