Cel Excessive delays in treatment onset limit current tuberculosis (TB) control programs, presenting a major obstacle to the control of the TB epidemic. Increasing case detection, both quantitatively and temporally, is considered a priority, benefiting the patient (reduced morbidity and mortality) and the society (shortened period of infectiousness). These improvements in patient care have a common goal: to reduce transmission and eventually contain the spread of TB within the population. However, assessing reduced transmission of TB proofs to be difficult, as to date molecular tools have not been integrated in mathematical models or in field trials of public health interventions. Therefore, I aim to develop a model that incorporates bacterial genotyping to follow TB transmission within the human host population, hypothesizing that an effective Enhanced-Case-Finding (ECF) method can interrupt TB transmission. Integration of routine epidemiological and genotyping data with bioinformatics and mathematical modelling provides a novel and powerful approach to understand the key determinants of the TB epidemic, such as the Effective Reproductive Number, and predict the dynamics of TB transmission. I have the unique opportunity to position the present proposal as an added-value study that builds on 3-year Cluster Randomized Trial of ECF that I designed, which is about to be launched in The Gambia in 2012. By applying molecular genotyping methods to bacterial isolates collected from both the ECF intervention- and control arm, I will develop a method to measure and model the impact of ECF on the transmission of TB. This will be the first study of its kind in integrating molecular genotyping data in a TB transmission model as applied to a population level interventional study. The identification of significant transmission parameters will be important both for basic TB research and also for health experts that design and evaluate Public Health TB interventions in the future. Dziedzina nauki medical and health scienceshealth sciencespublic healthsocial sciencessociologydemographymortalitynatural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesclinical medicinepneumologytuberculosisnatural sciencesmathematicsapplied mathematicsmathematical model Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-SG-LS7 - Applied life sciences, biotechnology and bioengineering: agricultural, animal, fishery, forestry/food sciences; biotechnology, chemical biology, genetic engineering, synthetic biology, industrial biosciences; environmental biotechnology. Zaproszenie do składania wniosków ERC-2012-StG_20111109 Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-SG - ERC Starting Grant Instytucja przyjmująca INSTITUUT VOOR TROPISCHE GENEESKUNDE Wkład UE € 1 345 787,20 Adres NATIONALESTRAAT 155 2000 ANTWERPEN Belgia Zobacz na mapie Region Vlaams Gewest Prov. Antwerpen Arr. Antwerpen Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Nadine Van Peer (Ms.) Kierownik naukowy Bouke Catherine De Jong (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (2) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko INSTITUUT VOOR TROPISCHE GENEESKUNDE Belgia Wkład UE € 1 345 787,20 Adres NATIONALESTRAAT 155 2000 ANTWERPEN Zobacz na mapie Region Vlaams Gewest Prov. Antwerpen Arr. Antwerpen Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Nadine Van Peer (Ms.) Kierownik naukowy Bouke Catherine De Jong (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych MEDICAL RESEARCH COUNCIL Zjednoczone Królestwo Wkład UE € 145 198,80 Adres 20 Park Crescent W1B 1AL LONDON Zobacz na mapie Rodzaj działalności Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Kontakt administracyjny Dembo Kanteh (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych