Cel Combatting and eventually eradicating the new coronavirus causing Severe Acute Respiratory Syndrome (SARS) requires specific and efficient antiviral drugs and improved diagnostics. The Sino-European Project on SARS Diagnostics and Antivirals (SEPSDA) is an integrated project that applies modern biotechnical technology for the generation of improved diagnostics and of lead compounds for antiviral drugs. SEPSDA brings together leading SARS researchers from Germany, Denmark, Poland, and China, who together have an excellent publication record on the molecular biology of SARS coronavirus (SARS-CoV). Several of the existing anti-SARS drug leads as well as the first antibody-based diagnostic kit were created by members of SEPSDA. Participation of four leading laboratories in China brings SEPSDA in the unique position of having access to samples from Chinese patients at various stages of disease. Serological studies will lead to improved SARS diagnostics. Analysis of the genome and the proteome of SARS coronavirus by sequencing and advanced bioinformatics will further determine the genetic variability of the virus isolates and identify new possible targets for therapeutic intervention, both at the RNA and the protein level. SEPSDA aims at determining the three-dimensional structures of all soluble SARS-CoV proteins or domains thereof. This structural genomics approach will provide the basis for the virtual screening of large compound databases, including those containing Chinese traditional medicines, for molecules potentially interfering with the function of the viral proteins or their interaction partners in the host cell. Candidate inhibitors will be tested in cell culture and improved by synthetic chemistry. After patenting, the lead compounds will be offered to an industrial platform on SARS, yet to be created, which should form an interface between SEPSDA and the pharmaceutical industry. Dziedzina nauki medical and health scienceshealth sciencesinfectious diseasesRNA virusescoronaviruses Słowa kluczowe Cristallography Program(-y) FP6-POLICIES - Policy support: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Temat(-y) POLICIES-2.2 - Public health issues, including epidemiology contributing to disease prevention and responses to emerging rare and communicable diseases, allergies, procedures for secure blood and organ donations, non-animal test methods Zaproszenie do składania wniosków FP6-2003-SSP-2-SARS Zobacz inne projekty w ramach tego zaproszenia System finansowania STREP - Specific Targeted Research Project Koordynator UNIVERSITY OF LUEBECK Wkład UE Brak danych Adres Ratzeburger Allee 160 LUEBECK Niemcy Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (7) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko UNIVERSITY OF AARHUS Dania Wkład UE Brak danych Adres Nordre Ringgade 1 AARHUS C Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych BIOINFOBANK INSTITUTE Polska Wkład UE Brak danych Adres Limanowskiego 24/a POZNAN Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych EUROIMMUN, MEDIZINISCHE LABORDIAGNOSTIKA AG Niemcy Wkład UE Brak danych Adres Seekamp 31 LUEBECK Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych TSINGHUA UNIVERSITY Chiny Wkład UE Brak danych Adres Tsinghua University BEIJING Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES Chiny Wkład UE Brak danych Adres 555 Zu Chong Zhi Road SHANGHAI Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych NATIONAL CENTER FOR CLINICAL LABORATORY, P.R.C. Chiny Wkład UE Brak danych Adres NO.1 Dahua Road,Dongdan BEIJING Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych BEIJING GENOMICS INSTITUTE, CHINESE ACADEMY OF SCIENCES Chiny Wkład UE Brak danych Adres B-6 Airport Industrial Zone BEIJING Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych
