Cel The scope of the project is to generate a candidate drug targeting the inflammatory mediator High mobility group box 1 protein (HMGB1) to be used in treatment of stroke. The candidate drug will be validated in animal models, characterized and optimized for subsequent clinical development.Stroke remains a leading cause of death and disability throughout the world. Within EU, more than 500 000 persons die of stroke each year. Of those surviving stroke, 50% are left with physical or cognitive impairment and the total annual cost of stroke is estimated at Euro 27 billion.Stroke occurs as a consequence of hemorrhagic insult or artery occlusion due to underlying cardiovascular disease. Pivotal in beneficial treatment of stroke is instant intervention. Blood clot dissolution using recombinant tissue plasminogen activator is the only pharmacological treatment demonstrated to limit neurological damage in stroke, but is only effective for patients who present within 3 hours after stroke onset. Thus there is an unmet need for an efficacious therapy that can be administered within and beyond 3 hours to achieve neuroprotection. HMGB1, released during the cerebral ischemic event and the subsequent neuroinflammation, is a well-characterized mediator of inflammation. Beneficial effects of blocking HMGB1 is proven in preclinical stroke studies. The drug to be developed is an Affibody molecule binding to and neutralizing HMGB1. Affibody molecules are engineered proteins significantly smaller than antibodies and therefore having favorable biodistribution properties, and a history of being efficient and non-toxic in clinical trials. In this application, we describe a multidisciplinary research consortium with Europe´s leading scientists in HMGB1 research and in registry-based clinical trial and dissemination methodology. The consortium has unique potentials to bring a new treatment principle against cerebral stroke to clinical reality. Dziedzina nauki humanitieshistory and archaeologyhistorynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicinecardiologycardiovascular diseasesmedical and health sciencesbasic medicineneurologystroke Program(-y) FP7-HEALTH - Specific Programme "Cooperation": Health Temat(-y) HEALTH.2013.2.4.2-1 - Discovery research to reveal novel targets for cardiovascular disease treatment Zaproszenie do składania wniosków FP7-HEALTH-2013-INNOVATION-1 Zobacz inne projekty w ramach tego zaproszenia System finansowania CP-FP - Small or medium-scale focused research project Koordynator KAROLINSKA INSTITUTET Wkład UE € 1 061 198,40 Adres Nobels Vag 5 17177 Stockholm Szwecja Zobacz na mapie Region Östra Sverige Stockholm Stockholms län Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Caroline Hamilton (Mrs.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (5) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko AFFIBODY AB Szwecja Wkład UE € 3 121 291,00 Adres GUNNAR ASPLUNDS ALLE 24 171 63 Solna Zobacz na mapie Region Östra Sverige Stockholm Stockholms län Rodzaj działalności Private for-profit entities (excluding Higher or Secondary Education Establishments) Kontakt administracyjny Fredrik Frejd (Prof.) Linki Kontakt z organizacją Opens in new window Koszt całkowity Brak danych HMGBIOTECH SRL Włochy Wkład UE € 576 712,00 Adres PIAZZALE GORINI PAOLO 8 20133 Milano Zobacz na mapie Region Nord-Ovest Lombardia Milano Rodzaj działalności Private for-profit entities (excluding Higher or Secondary Education Establishments) Kontakt administracyjny Maura Casalgrandi (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych THE UNIVERSITY OF LIVERPOOL Zjednoczone Królestwo Wkład UE € 396 562,00 Adres BROWNLOW HILL 765 FOUNDATION BUILDING L69 7ZX Liverpool Zobacz na mapie Region North West (England) Merseyside Liverpool Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Daniel Antoine (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITA VITA-SALUTE SAN RAFFAELE Włochy Wkład UE € 454 073,60 Adres VIA OLGETTINA 58 20132 Milano Zobacz na mapie Region Nord-Ovest Lombardia Milano Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Maria Rosa Pedrazzi (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych CHARITE - UNIVERSITAETSMEDIZIN BERLIN Niemcy Wkład UE € 379 794,00 Adres Chariteplatz 1 10117 Berlin Zobacz na mapie Region Berlin Berlin Berlin Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Karen Gertz (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych