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Exploring Functional and Developmental Osteoclast Heterogeneity in Health and Disease

Cel

Euroclast proposes a research training program on osteoclast biology in the context of osteoclast-driven diseases. Osteoclasts are the complex, multinuclear cells responsible for bone breakdown. Many diseases of osteoclast malfunctioning manifest in bone loss, for example, osteoporosis, cancer-induced bone disease, periodontitis, or rheumatoid arthritis, all conditions set to increase in an ageing EU population. The Euroclast consortium (7 academic, 2 private and 1 ass. partner) focuses on osteoclast heterogeneity, a recent insight that poses new fundamental questions best tackled by a multi-partner consortium capable of assembling the sophisticated molecular, genetic and imaging tools required. We will analyze changes in gene and protein expression during osteoclast (trans)differentiation from different precursor cell pools and in various bone sites and relate this to osteoclast activity and sensitivity to therapeutics. The osteoclast resorptive
apparatus will be studied using in depth and will define the key enzymatic and molecular machinery to be translated into novel site-specific drug targets or biomarkers. High throughput screening assays for therapeutics and ELISAs for biomarkers will be developed with our private partners. Our multidisciplinary and cross-sectorial approach will improve understanding and treatment of common disorders associated with osteoclast malfunction and train 11 early stage researchers (ESRs) in modern cell and bone biology. We will provide extensive training in generic skills and all ESRs will spend time with our private partners and be seconded to other academic partners to ensure they are well equipped for employment in research and industrial settings. Euroclast will produce an on-line repository for osteoclast protocols, make methodological and scientific advances in osteoclast and bone biology and create a sustainable network of ESRs and senior academics to tackle diseases of bone loss into the future.

Zaproszenie do składania wniosków

FP7-PEOPLE-2013-ITN
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Koordynator

STICHTING VU
Adres
De Boelelaan 1105
1081 HV Amsterdam
Niderlandy
Rodzaj działalności
Higher or Secondary Education Establishments
Wkład UE
€ 746 011,42

Uczestnicy (9)

THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN
United Kingdom
Wkład UE
€ 604 213,28
Adres
King's College Regent Walk
AB24 3FX Aberdeen
Rodzaj działalności
Higher or Secondary Education Establishments
CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL
Niemcy
Wkład UE
€ 227 568,88
Adres
Olshausenstrasse 40
24118 Kiel
Rodzaj działalności
Higher or Secondary Education Establishments
KAROLINSKA INSTITUTET
Szwecja
Wkład UE
€ 265 425,16
Adres
Nobels Vag 5
17177 Stockholm
Rodzaj działalności
Higher or Secondary Education Establishments
GOETEBORGS UNIVERSITET
Szwecja
Wkład UE
€ 265 425,16
Adres
Vasaparken
405 30 Goeteborg
Rodzaj działalności
Higher or Secondary Education Establishments
TECHNISCHE UNIVERSITAET DRESDEN
Niemcy
Wkład UE
€ 227 568,88
Adres
Helmholtzstrasse 10
01069 Dresden
Rodzaj działalności
Higher or Secondary Education Establishments
TURUN YLIOPISTO
Finlandia
Wkład UE
€ 266 697,64
Adres
Yliopistonmaki
20014 Turku
Rodzaj działalności
Higher or Secondary Education Establishments
NORDIC BIOSCIENCE COMPOUND DEVELOPMENT A/S
Dania
Wkład UE
€ 290 079,46
Adres
Herlev Hovedgade 207
2730 Helev
Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUTURE DIAGNOSTICS BV

Zakończenie uczestnictwa

Niderlandy
Adres
Nieuweweg 279
6603 BN Wijchen
Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUTURE DIAGNOSTICS SOLUTIONS BV
Niderlandy
Wkład UE
€ 242 361,46
Adres
Nieuweweg 279
6603 BN Wijchen
Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)