The Network has striven towards the study of protein dynamics, the development of state-of-the-art infrastructures and software suites for the use of the European and global scientific and industrial community and for the development of the Industrial Partners.
The main results are: advancements in the production of integrated software suites for time resolved protein studies at synchrotron and XFEL, production of engineered proteins for theranostics and their studies by time resolved methods at synchrotron and XFELs, determination of the structure of crucial drug targets (antibiotics and GPCRs), commissioning of time resolved synchrotron sources and implementation of new methods for data collection and analysis at existing ones, development of methodologies for production and analysis of micro and nano-crystals.
Ten ESRs have been recruited enhancing transnational mobility in the EU and attracting brilliant young scientists with outstanding potential from non-EU Countries. Nine training events took place on ”Frontier methods for visualizing proteins structural dynamics and their applications”, “Protein Structural dynamics: biological systems and experimental strategies”, “Commercialization of science”, “Project management and transferable skills” and “Serial crystallography at FELs and synchrotrons”, “The role of science in society, public outreach, career development and gender issues, “ Drug discovery from a structure and biophysics perspective” and a final Conference on “Novel Methods for Biomolecular Structure Determination”. Some of the training events included hands-on training. The ESRs have formed a team and are in contact, with a positive and supportive attitude, they have benefited of several joint experimental sessions. Collaborations have been cemented and new collaborations have been established also at the intersectorial level.
Dissemination activities have been carried out, at about 30 scientific events, including presentations by the ESRs. Outreach activities to communicate about the network, the scientific relevance of protein dynamics studies at synchrotron and XFEL and about MSCA-H2020 actions included an events targeted to schools in France, Italy, Germany and Switzerland, events at Open Door Days at synchrotrons (Hamburg, Villigen, ESRF) and a talk given by one of the ESRs at a Marie Curie Day (Gothenburg).
