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Innovative peptides against cancer and pathogenic bacteria, with advances in science, biopharmaceutical drug development, product market targeting, training , and communication.

Rezultaty

Outreaching Outputs

During the four years of INPACT we aim to achieve regular non-specialised press news by participating in the Researchers’ Nights, World Cancer Day, and the European Antibiotic Awareness Day. Technological achievements will be announced by joint international press releases; our goal is to have at least five different national news disseminated in the countries directly involved in the creation of those technologies during the course of INPACT. Open days will occur in each of the participating institutions and aim at having at least 60 visitors from general public, including students and patient association affiliates, five journalists, and two politicians with power to make decisions. We anticipate that members in INPACT team will be invited to participate into four, or more, public initiatives per year organized by third parties’.

Products

New technologies to be adopted by the partner SMEs or to be sold to third parties. The quantitative goal is to generate two drug leads to treat each of the following conditions: brain tumour, blood tumour and metastatic circulating cells, and MRSA infection. Inherent to the previous deliverable, new Intellectual Property Rights (IPR) will be built from existing IPR of the partners.

Dissemination Outputs

We expect to file at least three patents to protect new technologies. The patents are, by themselves, vehicles of dissemination but INPACT will also have R&D papers as deliverables. Our aim is to have at least six papers published in high-quality (Quartile 1 in impact factor ranking) international journals. We also aim at having three seminars and/or satellite meetings organized in the context of large-scale scientific meetings (>500 participants) and at presenting the results obtained within INPACT project in at least eight international conferences.

Training and career development

Training activities in INPACT will provide both intersectoral and international training, namely, i) Experience in working in non-academic environments (>4 months: training will be given by CEAMED, TCP, PTD or ICH to at least five PhD students) and ii) Experience in working with distinct cultural environment (>3 months in a foreign country to at least 10 ESRs). Additional information in Table 3 - Secondments description.

Publikacje

Psd1 Effects on Candida albicans Planktonic Cells and Biofilms

Autorzy: Sónia Gonçalves, Patrícia M. Silva, Mário R. Felício, Luciano N. de Medeiros, Eleonora Kurtenbach, Nuno C. Santos
Opublikowane w: Frontiers in Cellular and Infection Microbiology, Numer 7, 2017, ISSN 2235-2988
Wydawca: Frontiers Media S. A.
DOI: 10.3389/fcimb.2017.00249

Peptides with Dual Antimicrobial and Anticancer Activities

Autorzy: Mário R. Felício, Osmar N. Silva, Sônia Gonçalves, Nuno C. Santos, Octávio L. Franco
Opublikowane w: Frontiers in Chemistry, Numer 5, 2017, ISSN 1664-302X
Wydawca: Frontiers Media
DOI: 10.3389/fchem.2017.00005

New Potent Membrane-Targeting Antibacterial Peptides from Viral Capsid Proteins

Autorzy: Susana A. Dias, João M. Freire, Clara Pérez-Peinado, Marco M. Domingues, Diana Gaspar, Nuno Vale, Paula Gomes, David Andreu, Sónia T. Henriques, Miguel A. R. B. Castanho, Ana S. Veiga
Opublikowane w: Frontiers in Microbiology, Numer 8, 2017, ISSN 1664-302X
Wydawca: Frontiers Media
DOI: 10.3389/fmicb.2017.00775

Pharmacological Potential of the Endogenous Dipeptide Kyotorphin and Selected Derivatives

Autorzy: Juliana Perazzo, Miguel A. R. B. Castanho, Sónia Sá Santos
Opublikowane w: Frontiers in Pharmacology, Numer 7, 2017, ISSN 1663-9812
Wydawca: Frontiers Media S.A.
DOI: 10.3389/fphar.2016.00530

Neuropeptide Kyotorphin Impacts on Lipopolysaccharide-Induced Glucocorticoid-Mediated Inflammatory Response. A Molecular Link to Nociception, Neuroprotection, and Anti-Inflammatory Action

Autorzy: Juliana Perazzo, Carla Lima, Montserrat Heras, Eduard Bardají, Mônica Lopes-Ferreira, Miguel Castanho
Opublikowane w: ACS Chemical Neuroscience, Numer 8/8, 2017, Strona(/y) 1663-1667, ISSN 1948-7193
Wydawca: American Chemical Society
DOI: 10.1021/acschemneuro.7b00007

A New Noncanonical Anionic Peptide That Translocates a Cellular Blood–Brain Barrier Model

Autorzy: Sara Neves-Coelho, Rute Eleutério, Francisco Enguita, Vera Neves, Miguel Castanho
Opublikowane w: Molecules, Numer 22/10, 2017, Strona(/y) 1753, ISSN 1420-3049
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules22101753

Endothelium-Mediated Action of Analogues of the Endogenous Neuropeptide Kyotorphin (Tyrosil-Arginine): Mechanistic Insights from Permeation and Effects on Microcirculation

Autorzy: Juliana Perazzo, Mônica Lopes-Ferreira, Sónia Sá Santos, Isa Serrano, Antónia Pinto, Carla Lima, Eduard Bardaji, Isaura Tavares, Montserrat Heras, Katia Conceição, Miguel A. R. B. Castanho
Opublikowane w: ACS Chemical Neuroscience, Numer 7/8, 2016, Strona(/y) 1130-1140, ISSN 1948-7193
Wydawca: American Chemical Society
DOI: 10.1021/acschemneuro.6b00099

Mechanisms of Vesicular Stomatitis Virus Inactivation by Protoporphyrin IX, Zinc-Protoporphyrin IX, and Mesoporphyrin IX

Autorzy: Christine Cruz-Oliveira, Andreza F. Almeida, João M. Freire, Marjolly B. Caruso, Maria A. Morando, Vivian N. S. Ferreira, Iranaia Assunção-Miranda, Andre M. O. Gomes, Miguel A. R. B. Castanho, Andrea T. Da Poian
Opublikowane w: Antimicrobial Agents and Chemotherapy, Numer 61/6, 2017, Strona(/y) e00053-17, ISSN 0066-4804
Wydawca: American Society for Microbiology
DOI: 10.1128/AAC.00053-17

Challenging metastatic breast cancer with the natural defensin PvD 1

Autorzy: Tiago N. Figueira, Filipa D. Oliveira, Inês Almeida, Érica O. Mello, Valdirene M. Gomes, Miguel A. R. B. Castanho, Diana Gaspar
Opublikowane w: Nanoscale, Numer 9/43, 2017, Strona(/y) 16887-16899, ISSN 2040-3364
Wydawca: Royal Society of Chemistry
DOI: 10.1039/c7nr05872a

A polyalanine peptide derived from polar fish with anti-infectious activities

Autorzy: Marlon H. Cardoso, Suzana M. Ribeiro, Diego O. Nolasco, César de la Fuente-Núñez, Mário R. Felício, Sónia Gonçalves, Carolina O. Matos, Luciano M. Liao, Nuno C. Santos, Robert E. W. Hancock, Octávio L. Franco, Ludovico Migliolo
Opublikowane w: Scientific Reports, Numer 6, 2016, Strona(/y) 21385, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/srep21385

Antibody Approaches To Treat Brain Diseases

Autorzy: Vera Neves, Frederico Aires-da-Silva, Sofia Corte-Real, Miguel A.R.B. Castanho
Opublikowane w: Trends in Biotechnology, Numer 34/1, 2016, Strona(/y) 36-48, ISSN 0167-7799
Wydawca: Elsevier BV
DOI: 10.1016/j.tibtech.2015.10.005

Shifting gear in antimicrobial and anticancer peptides biophysical studies: from vesicles to cells

Autorzy: João M. Freire, Diana Gaspar, Ana Salomé Veiga, Miguel A. R. B. Castanho
Opublikowane w: Journal of Peptide Science, Numer 21/3, 2015, Strona(/y) 178-185, ISSN 1075-2617
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/psc.2741

Structural and functional evaluation of the palindromic alanine-rich antimicrobial peptide Pa-MAP2

Autorzy: Ludovico Migliolo, Mário R. Felício, Marlon H. Cardoso, Osmar N. Silva, Mary-Ann E. Xavier, Diego O. Nolasco, Adeliana Silva de Oliveira, Ignasi Roca-Subira, Jordi Vila Estape, Leandro D. Teixeira, Sonia M. Freitas, Anselmo J. Otero-Gonzalez, Sónia Gonçalves, Nuno C. Santos, Octavio L. Franco
Opublikowane w: Biochimica et Biophysica Acta (BBA) - Biomembranes, Numer 1858/7, 2016, Strona(/y) 1488-1498, ISSN 0005-2736
Wydawca: Elsevier BV
DOI: 10.1016/j.bbamem.2016.04.003

Rethinking the capsid proteins of enveloped viruses: multifunctionality from genome packaging to genome transfection

Autorzy: João M. Freire, Nuno C. Santos, Ana Salomé Veiga, Andrea T. Da Poian, Miguel A. R. B. Castanho
Opublikowane w: FEBS Journal, Numer 282/12, 2015, Strona(/y) 2267-2278, ISSN 1742-464X
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/febs.13274

New frontiers for anti-biofilm drug development

Autorzy: Suzana M. Ribeiro, Mário R. Felício, Esther Vilas Boas, Sónia Gonçalves, Fabrício F. Costa, Ramar Perumal Samy, Nuno C. Santos, Octávio L. Franco
Opublikowane w: Pharmacology & Therapeutics, Numer 160, 2016, Strona(/y) 133-144, ISSN 0163-7258
Wydawca: Pergamon Press
DOI: 10.1016/j.pharmthera.2016.02.006

Peptibodies: An elegant solution for a long-standing problem

Autorzy: Marco Cavaco, Miguel A. R. B. Castanho, Vera Neves
Opublikowane w: Peptide Science, Numer 110/1, 2018, Strona(/y) e23095, ISSN 2475-8817
Wydawca: PeptideScience
DOI: 10.1002/bip.23095

Mechanisms of bacterial membrane permeabilization by crotalicidin (Ctn) and its fragment Ctn(15–34), antimicrobial peptides from rattlesnake venom

Autorzy: Clara Pérez-Peinado, Susana Almeida Dias, Marco M. Domingues, Aurélie H. Benfield, João Miguel Freire, Gandhi Rádis-Baptista, Diana Gaspar, Miguel A. R. B. Castanho, David J. Craik, Sónia Troeira Henriques, Ana Salomé Veiga, David Andreu
Opublikowane w: Journal of Biological Chemistry, Numer 293/5, 2018, Strona(/y) 1536-1549, ISSN 0021-9258
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra117.000125

Fast and potent bactericidal membrane lytic activity of PaDBS1R1, a novel cationic antimicrobial peptide

Autorzy: Luz N. Irazazabal, William F. Porto, Isabel C.M. Fensterseifer, Eliane S.F. Alves, Carolina O. Matos, Antônio C.S. Menezes, Mário R. Felício, Sónia Gonçalves, Nuno C. Santos, Suzana M. Ribeiro, Vincent Humblot, Luciano M. Lião, Ali Ladram, Octavio L. Franco
Opublikowane w: Biochimica et Biophysica Acta (BBA) - Biomembranes, Numer 1861/1, 2019, Strona(/y) 178-190, ISSN 0005-2736
Wydawca: Elsevier BV
DOI: 10.1016/j.bbamem.2018.08.001

Designing improved active peptides for therapeutic approaches against infectious diseases

Autorzy: Bárbara Gomes, Marcelo T. Augusto, Mário R. Felício, Axel Hollmann, Octávio L. Franco, Sónia Gonçalves, Nuno C. Santos
Opublikowane w: Biotechnology Advances, Numer 36/2, 2018, Strona(/y) 415-429, ISSN 0734-9750
Wydawca: Elsevier BV
DOI: 10.1016/j.biotechadv.2018.01.004

Novel Peptides Derived from Dengue Virus Capsid Protein Translocate Reversibly the Blood–Brain Barrier through a Receptor-Free Mechanism

Autorzy: Vera Neves , Frederico Aires-da-Silva, Maurício Morais, Lurdes Gano, Elisabete Ribeiro, Antónia Pinto, Sandra Aguiar, Diana Gaspar, Célia Fernandes, João D. G. Correia, and Miguel A. R. B. Castanho
Opublikowane w: ACS Chemical Biology, 2017, ISSN 1554-8929
Wydawca: American Chemical Society
DOI: 10.1021/acschembio.7b00087

Prawa własności intelektualnej

ANTIBODY MOLECULES AND PEPTIDE DELIVERY SYSTEMS FOR USE IN ALZHEIMER'S DISEASE AND RELATED DISORDERS

Numer wniosku/publikacji: WO 2016/120843
Data: 2016-01-29
Wnioskodawca/wnioskodawcy: TECHNOPHAGE INVESTIGACAO E DESENVOLVIMENTO EM BIOTECNOLOGIA SA

ANTIBODY MOLECULES AND PEPTIDE DELIVERY SYSTEMS FOR USE IN ALZHEIMER'S DISEASE AND RELATED DISORDERS

Numer wniosku/publikacji: WO 2016/120843
Data: 2016-01-29
Wnioskodawca/wnioskodawcy: TECHNOPHAGE INVESTIGACAO E DESENVOLVIMENTO EM BIOTECNOLOGIA SA

ANTIBODY MOLECULES AND PEPTIDE DELIVERY SYSTEMS FOR USE IN ALZHEIMER'S DISEASE AND RELATED DISORDERS

Numer wniosku/publikacji: WO 2016/120843
Data: 2016-01-29

ANTIBODY MOLECULES AND PEPTIDE DELIVERY SYSTEMS FOR USE IN ALZHEIMER'S DISEASE AND RELATED DISORDERS

Numer wniosku/publikacji: WO 2016/120843
Data: 2016-01-29
Wnioskodawca/wnioskodawcy: INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES

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