Cel Chronic heart failure is a leading cause of mortality in the industrialized countries. Pathomechanistically, a variety of diverse stress signals on the cardiomyocyte trigger loss of myofibrils and cardiomyocyte death, thereby activating a vicious cycle of cardiac stress and deterioration during terminal heart failure. Despite the enormous clinical relevance, the exact pathomechanisms in charge remains unclear.Here, I propose to investigate the molecular mechanisms that couple mechanical cardiomyocyte strain and cardiomyocyte loss during the heart failure involving the mechanosensing titin filament. For this, I will perform research in three globally leading teams and access their complementary expertise in a secondment scheme. In the the proposed 2-year outgoing phase, I will study how cardioprotection is mediated by key factors recently identified in the Ju Chen lab (UCSD, San Diego). During this time, I will be trained in cutting-edge molecular mouse genetic models and phenotyping tools. This research is expected to shed light on CARP-titinsignaling axis in cardiomyocyte death and to provide tools for manipulating this pathway. In a one-year re-integration phase I will perform follow-up mechanistic structural studies in the Olga Mayans lab (University of Liverpool) to determine the structural basis how the CARP (cardiac ankyrin repeat protein)-titin signaling axis mediates cardiomyocyte protection, and in the Labeit lab (University of Heidelberg, Medical Faculty Mannheim) how to perturb activity of this complex by small molecules.Taken together, this work encompasses structural studies at the atomic level up to vivo animal models to study CARP-titin functions. After the propose three years, I expect to be ready to pursue an independent career in the field of molecular cardiology research. Therefore, my goal during the re-integration phase will be to set-up an interdisciplinary collaboration involving the three lead teams of this proposal. Dziedzina nauki engineering and technologymaterials engineeringcrystalssocial sciencessociologydemographymortalitynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicinecardiologycardiovascular diseasesnatural sciencesbiological sciencesmolecular biology Program(-y) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Temat(-y) MSCA-IF-2014-GF - Marie Skłodowska-Curie Individual Fellowships (IF-GF) Zaproszenie do składania wniosków H2020-MSCA-IF-2014 Zobacz inne projekty w ramach tego zaproszenia System finansowania MSCA-IF-GF - Global Fellowships Koordynator ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT Wkład UE netto € 239 860,80 Adres Square J 5 68159 Mannheim Niemcy Zobacz na mapie Region Baden-Württemberg Karlsruhe Mannheim, Stadtkreis Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 239 860,80 Uczestnicy (1) Sortuj alfabetycznie Sortuj według wkładu UE netto Rozwiń wszystko Zwiń wszystko RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG Zakończenie uczestnictwa Niemcy Wkład UE netto € 0,00 Adres SEMINARSTRASSE 2 69117 Heidelberg Zobacz na mapie Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity Brak danych Partnerzy (1) Sortuj alfabetycznie Sortuj według wkładu UE netto Rozwiń wszystko Zwiń wszystko Partner Organizacje partnerskie biorą udział w realizacji działania, jednak nie podpisują umowy o grant. THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Stany Zjednoczone Wkład UE netto € 0,00 Adres FRANKLIN STREET 1111 12 FLOOR 94607 OAKLAND CA Zobacz na mapie Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 160 130,40