Targeting the Oncogenic Function of Myc in vivo

Informacje na temat projektu

TarMyc

Identyfikator umowy o grant: 759139

DOI

10.3030/759139

Projekt został zamknięty

Data podpisania przez KE 15 Września 2017

Data rozpoczęcia 1 Marca 2018

Data zakończenia 31 Sierpnia 2023

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 1 497 905,00

Wkład UE

€ 1 497 905,00

Koordynowany przez

JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
Germany

Periodic Reporting for period 4 - TarMyc (Targeting the Oncogenic Function of Myc in vivo)

Okres sprawozdawczy: 2022-09-01 do 2023-08-31

Podsumowanie kontekstu i ogólnych celów projektu

In ageing Western societies tumors are becoming the most relevant medical problem. Transcription factors of the Myc oncoprotein family are key players in the development of most human tumors. The central goal of TarMyc was to elucidate the critical oncogenic mechanism of MYC and to develop strategies to target MYC function for cancer therapy. By identifying critical target genes and binding partners of MYC as novel targets for cancer therapy.

Prace wykonane od początku projektu do końca okresu sprawozdawczego oraz najważniejsze dotychczasowe rezultaty

First, we developed systems to deplete MYC and MYC-associated proteins in cells and mice using both inducible shRNAs and targeted protein degradation systems. We observed that MYC regulates unique sets of genes when expressed at low, physiological, versus high, oncogenic levels. Oncogenic processes induced by MYC include angiogenesis, specific metabolic adaptations and, most importantly, immune evasion. Second, we identified and characterized MYC binding partners that are critical for the establishment of these oncogenic gene expression signatures. Third, we developed proteolysis targeting chimeras (PROTACs) for the most promising candidates and characterized their impact on tumor growth in vivo.

Innowacyjność oraz oczekiwany potencjalny wpływ (w tym dotychczasowe znaczenie społeczno-gospodarcze i szersze implikacje społeczne projektu)

Overall, the TarMyc project has laid the foundation for potential new anti-MYC-based cancer therapies.

Graphical abstract in the press release about a publication of my lab in Nature Chemical Biology.