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Targeting the Oncogenic Function of Myc in vivo

Publikacje

Targeting MYC Proteins for Tumor Therapy

Autorzy: Elmar Wolf, Martin Eilers
Opublikowane w: Annual Review of Cancer Biology, Issue 4/1, 2020, Page(s) 61-75, ISSN 2472-3428
Wydawca: Annual Reviews
DOI: 10.1146/annurev-cancerbio-030518-055826

NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer

Autorzy: Josefina Doffo, Stefanos A Bamopoulos, Hazal Köse, Felix Orben , Chuanbing Zang , Miriam Pons , Alexander T den Dekker , Rutger W W Brouwer, Apoorva Baluapuri , Stefan Habringer, Maximillian Reichert , Anuradha Illendula , Oliver H Krämer , Markus Schick, Elmar Wolf, Wilfred F J van IJcken, Irene Esposito, Ulrich Keller, Günter Schneider, Matthias Wirth
Opublikowane w: Proceedings of the National Academy of Sciences of the United States of America, 2022, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.2105691119

Generation of auxin inducible degron (AID) knock-in cell lines for targeted protein degradation in mammalian cells

Autorzy: Bikash Adhikari, Ashwin Narain, and Elmar Wolf
Opublikowane w: Star Protocols, 2021, ISSN 2666-1667
Wydawca: Cell Press Elsevier Inc.
DOI: 10.1016/j.xpro.2021.100949

Novel, highly potent PROTACs targeting AURORA-A kinase

Autorzy: Jelena Bozilovic, Lorenz Eing , Benedict-Tilman Berger, Bikash Adhikari, Janik Weckesser, Nicola B. Berner d, Stephanie Wilhelm, Bernhard Kuster, Elmar Wolf, Stefan Knapp
Opublikowane w: Current Research in Chemical Biology, 2022, ISSN 2666-2469
Wydawca: Elsevier
DOI: 10.1016/j.crchbi.2022.100032

MYC multimers shield stalled replication forks from RNA polymerase

Autorzy: Daniel Solvie, Apoorva Baluapuri, Leonie Uhl, Daniel Fleischhauer, Theresa Endres, Dimitrios Papadopoulos, Amel Aziba, Abdallah Gaballa, Ivan Mikicic, Ekaterina Isaakova, Celeste Giansanti, Jennifer Jansen, Marvin Jungblut, Teresa Klein, Christina Schülein-Völk, Hans Maric, Sören Doose, Markus Sauer, Petra Beli, Andreas Rosenwald, Matthias Dobbelstein, Elmar Wolf, Martin Eiles
Opublikowane w: Nature, 2022, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-022-05469-4

PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase

Autorzy: Bikash Adhikari, Jelena Bozilovic, Mathias Diebold, Jessica Denise Schwarz, Julia Hofstetter, Martin Schröder, Marek Wanior, Ashwin Narain, Markus Vogt, Nevenka Dudvarski Stankovic, Apoorva Baluapuri, Lars Schönemann, Lorenz Eing, Pranjali Bhandare, Bernhard Kuster, Andreas Schlosser, Stephanie Heinzlmeir, Christoph Sotriffer, Stefan Knapp, Elmar Wolf
Opublikowane w: Nature Chemical Biology, Issue 16/11, 2020, Page(s) 1179-1188, ISSN 1552-4450
Wydawca: Nature Publishing Group
DOI: 10.1038/s41589-020-00652-y

Target gene-independent functions of MYC oncoproteins

Autorzy: Apoorva Baluapuri, Elmar Wolf, Martin Eilers
Opublikowane w: Nature Reviews Molecular Cell Biology, Issue 21/5, 2020, Page(s) 255-267, ISSN 1471-0072
Wydawca: Nature Publishing Group
DOI: 10.1038/s41580-020-0215-2

MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation

Autorzy: Apoorva Baluapuri, Julia Hofstetter, Nevenka Dudvarski Stankovic, Theresa Endres, Pranjali Bhandare, Seychelle Monique Vos, Bikash Adhikari, Jessica Denise Schwarz, Ashwin Narain, Markus Vogt, Shuang-Yan Wang, Robert Düster, Lisa Anna Jung, Jens Thorsten Vanselow, Armin Wiegering, Matthias Geyer, Hans Michael Maric, Peter Gallant, Susanne Walz, Andreas Schlosser, Patrick Cramer, Martin Eilers, El
Opublikowane w: Molecular Cell, Issue 74/4, 2019, Page(s) 674-687.e11, ISSN 1097-2765
Wydawca: Cell Press
DOI: 10.1016/j.molcel.2019.02.031

Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders

Autorzy: Anja Dölle, Bikash Adhikari, Andreas Krämer, Janik Weckesser, Nicola Berner, Lena-Marie Berger, Mathias Diebold, Magdalena M. Szewczyk, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, Jakob Gebel, Frank Löhr, Volker Dötsch, Martin Eilers, Stephanie Heinzlmeir, Bernhard Kuster, Christoph Sotriffer, Elmar Wolf*, and Stefan Knapp*
Opublikowane w: Journal of Medicinal Chemistry, 2021, ISSN 0022-2623
Wydawca: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00146

MondoA drives malignancy in B-ALL through enhanced adaptation to metabolic stress

Autorzy: Alexandra Sipol, Erik Hameister, Busheng Xue, Julia Hofstetter, Maxim Barenboim, Rupert Öllinger, Gaurav Jain, Carolin Prexler, Rebeca Alba Rubio, Michaela C. Baldauf, Davide G. Franchina, Andreas Petry, Juliane Schmäh, Uwe Thiel, Agnes Görlach, Gunnar Cario, Dirk Brenner, Günther H. S. Richter, Thomas G. P. Grünewald, Roland Rad, Elmar Wolf, Jürgen Ruland, Poul H. Sorensen, Stefan E. G. Bur
Opublikowane w: BLOOD, 2021, ISSN 1528-0020
Wydawca: American Society of Hematology
DOI: 10.1182/blood.2020007932

The glycolytic enzyme ALDOA and the exon junction complex protein RBM8A are regulators of ribosomal biogenesis

Autorzy: Jessica Denise Schwarz, Sören Lukassen, Pranjali Bhandare, Lorenz Eing, Marteinn Thor Snaebjörnsson, Yiliam Cruz García, Jan Philipp Kisker, Almut Schulze and Elmar Wolf
Opublikowane w: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Wydawca: Frontiers Media
DOI: 10.3389/fcell.2022.954358

Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma

Autorzy: Angela Riedel, Moutaz Helal, Luisa Pedro, Jonathan J. Swietlik, David Shorthouse, Werner Schmitz , Lisa Haas, Timothy Young, Ana S.H. da Costa, Sarah Davidson, Pranjali Bhandare, Elmar Wolf, Benjamin A. Hall, Christian Frezza, Thordur Oskarsson, and Jacqueline D. Shields
Opublikowane w: CANCER IMMUNOLOGY RESEARCH, 2022, ISSN 2326-6066
Wydawca: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-21-0778

Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination

Autorzy: Ashwin Narain, Pranjali Bhandare, Bikash Adhikari, Simone Backes, Martin Eilers, Lars Dö lken, Andreas Schlosser, Florian Erhard, Apoorva Baluapuri, and Elmar Wolf
Opublikowane w: Molecular Cell, 2021, ISSN 1097-2765
Wydawca: Cell Press
DOI: 10.1016/j.molcel.2021.06.016

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