Personalised maxillofacial bone regeneration

Informacje na temat projektu

MAXIBONE

Identyfikator umowy o grant: 779322

DOI 10.3030/779322

Projekt został zamknięty

Data podpisania przez KE 27 Listopada 2017

Data rozpoczęcia 1 Stycznia 2018

Data zakończenia 30 Czerwca 2022

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity € 5 975 915,00

Wkład UE € 5 949 665,00

Koordynowany przez

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Rezultaty

Open Research Data Pilot (3)

Peer reviewed publication of the study in a high impact factor journal. Small animal study subcutis.

Title is selfdescribing additional details may be provided at request

Peer reviewed publication of the study in a high impact factor journal. Large animal study mandible

Title is self-describing, additional details may be provided at request

Peer reviewed publication of the study in a high impact factor journal. Small animal study mandibular critical size defect

Title is self-describing, additional details may be provided at request

Websites, patent fillings, videos etc. (1)

Website management : creation and update throughout the project

Please, refer to the WP4 description

Documents, reports (7)

Scientific Advisory Board reports

Four reports will be generated during the project the first one at M12 and then at M24 M36 and M54 due date indicated above

Completed recruitment and treatment delivery

Title is selfdescribing additional details may be provided at request

Develop a common clinical protocol for ethical committees and Medicine Agency submission

Includes investigator brochure, patient’s information sheets and consent forms in all languages from the participating centres.

Educational program for patients

A report will be generated twice during the project at M24 and at M48 due date indicated above

Outcomes of the recruitment by the different centres one year after the start of patient 1

To reassess the recruitment strategy in case of deviations from planning

Dissemination Committee reports

Four reports will be generated during the project the first one at M12 and then at M24 M36 and M54 due date indicated above

Educational programs associated with universities

Report on educational programs will be delivered at M24 for the first time and then repeated at M36 and M48 the due date indicated above

Other (1)

License for custom made medical device manufacturing

Title is selfdescribing additional details may be provided at request

Publikacje

Peer reviewed articles (4)

Impact of humanised isolation and culture conditions on stemness and osteogenic potential of bone marrow derived mesenchymal stromal cells

Autorzy: Suliman S, Ali HRW, Karlsen TA, Amiaud J, Mohamed-Ahmed S, Layrolle P, Costea DE, Brinchmann JE, Mustafa K
Opublikowane w: Scientific Reports, 2019, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-019-52442-9

Extracellular Vesicles Derived from Primed Mesenchymal Stromal Cells Loaded on Biphasic Calcium Phosphate Biomaterial Exhibit Enhanced Macrophage Polarization

Autorzy: Rana N, Suliman S, Al-Sharabi N, Mustafa K
Opublikowane w: Cells, 2022, ISSN 2073-4409
Wydawca: MDP
DOI: 10.3390/cells11030470

Influence of Bone Substitutes on Mesenchymal Stromal Cells in an Inflammatory Microenvironment

Autorzy: Shanbhag S, Rana N, Suliman S, Idris SB, Mustafa K, Stavropoulos A.
Opublikowane w: Int J Mol Sci., 2022, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24010438

A Comparative In Vitro and In Vivo Study of Osteogenicity by Using Two Biomaterials and Two Human Mesenchymal Stem Cell Subtypes

Autorzy: Fievet L, Serratrice N, Brulin B, Giraudo L, Véran J, Degardin N, Sabatier F, Féron F, Layrolle P.
Opublikowane w: Front. Cell Dev. Biol, 2022, ISSN 2296-634X
Wydawca: Frontiers
DOI: 10.3389/fcell.2022.913539