Novel Bone Regeneration Drug Osteogrow: Therapeutic Solution for Lumbar Back Pain

Rezultaty

A data management plan will be developed in line with Guidelines on FAIR Data Management in Horizon 2020 The DMP covers the complete research data life cycle It describes the types of data that will be generated or collected during the project the standards that will be used how data will be preserved and what parts will be shared for verification or use We are aware of sensitivity of clinical data related to personal data protection as well as exploitation and licensing needs so we shall keep certain data closed and stick with as open as possible as closed as necessary This means that we will partially optout but will prepare a DMP in accordance with the ORDP and GA Article 29

Report on status of posting results
Open access summary report

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Audiovisual material

Public project website

Publikacje

A novel autologous bone graft substitute containing rhBMP6 in autologous blood coagulum with synthetic ceramics for reconstruction of a large humerus segmental gunshot defect in a dog: The first veterinary patient to receive a novel osteoinductive therapy

Autorzy: Marko Pecin, Nikola Stokovic, Natalia Ivanjko, Ana Smajlovic, Mario Kreszinger, Hrvoje Capak, Zoran Vrbanac, Hermann Oppermann, Drazen Maticic, Slobodan Vukicevic
Opublikowane w: Bone Reports, Numer 14, 2021, Strona(/y) 100759, ISSN 2352-1872
Wydawca: Elsevier Inc.
DOI: 10.1016/j.bonr.2021.100759

Bone Morphogenetic Proteins, Carriers, and Animal Models in the Development of Novel Bone Regenerative Therapies

Autorzy: Nikola Stokovic, Natalia Ivanjko, Drazen Maticic, Frank P. Luyten, Slobodan Vukicevic
Opublikowane w: Materials, Numer 14/13, 2021, Strona(/y) 3513, ISSN 1996-1944
Wydawca: MDPI Open Access Publishing
DOI: 10.3390/ma14133513

Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats

Autorzy: Nikola Stokovic, Natalia Ivanjko, Igor Erjavec, Anita Breski, Mihaela Peric, Slobodan Vukicevic
Opublikowane w: Biomedicines, Numer 9/10, 2021, Strona(/y) 1487, ISSN 2227-9059
Wydawca: MDPI
DOI: 10.3390/biomedicines9101487

Evaluation of synthetic ceramics as compression resistant matrix to promote osteogenesis of autologous blood coagulum containing recombinant human bone morphogenetic protein 6 in rabbit posterolateral lumbar fusion model

Autorzy: Nikola Štoković, Natalia Ivanjko, Marko Pećin, Igor Erjavec, Sven Karlović, Ana Smajlović, Hrvoje Capak, Milan Milošević, Jadranka Bubić Špoljar, Dražen Vnuk, Dražen Matičić, Hermann Oppermann, T. Kuber Sampath, Slobodan Vukičević
Opublikowane w: Bone, Numer 140, 2020, Strona(/y) 115544, ISSN 8756-3282
Wydawca: Elsevier BV
DOI: 10.1016/j.bone.2020.115544

A simple rodent subcutaneous assay for identification of new osteoinductive molecules: The key method for screening of novel bone regeneration implants

Autorzy: Stokovic, N. Ivanjko, M. Milesevic, K. Sampath, S. Vukicevic
Opublikowane w: RAD CASA - Medical Sciences, Numer Vol 553, 2022, Strona(/y) 40-53, ISSN 1848-641X
Wydawca: Croatian Academy of Sciences and Art
DOI: 10.21857/y54jofvgxm

Bone morphogenetic proteins: From discovery to development of a novel autologous bone graft substitute consisting of recombinant human BMP6 delivered in autologous blood coagulum carrier

Autorzy: Slobodan Vukičević, Mihaela Perić, Hermann Oppermann, Nikola Štoković, Natalia Ivanjko, Igor Erjavec, Vera Kufner, Dražen Vnuk, Jadranka Bubić Špoljar, Marko Pećin, Ruđer Novak, Ivona Matić Jelić, Kristian Bakić, Marina Milešević, Viktorija Rumenović, Irena Popek, Sanja Pehar, Snježana Martinović, Valentina Blažević, Lucija Rogina, Smiljka Vikić-Topić, Tamara Božić, Donatel
Opublikowane w: Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti, Numer 544/52-53, 2020, Strona(/y) 26-41, ISSN 1330-5301
Wydawca: RAD HAZU
DOI: 10.21857/mnlqgc5vgy

Autologous blood coagulum is a physiological carrier for BMP6 to induce new bone formation and promote posterolateral lumbar spine fusion in rabbits

Autorzy: Slobodan Vukicevic, Lovorka Grgurevic, Igor Erjavec, Marko Pecin, Tatjana Bordukalo‐Niksic, Nikola Stokovic, Marija Lipar, Hrvoje Capak, Drazen Maticic, Reinhard Windhager, T. Kuber Sampath, Munish Gupta
Opublikowane w: Journal of Tissue Engineering and Regenerative Medicine, Numer 14/1, 2019, Strona(/y) 147-159, ISSN 1932-6254
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/term.2981

A novel autologous bone graft substitute comprised of rhBMP6 blood coagulum as carrier tested in a randomized and controlled Phase I trial in patients with distal radial fractures

Autorzy: Dragan Durdevic, Tomislav Vlahovic, Sanja Pehar, Dina Miklic, Hermann Oppermann, Tatjana Bordukalo-Niksic, Ismet Gavrankapetanovic, Mehmed Jamakosmanovic, Milan Milosevic, Snjezana Martinovic, T. Kuber Sampath, Mihaela Peric, Lovorka Grgurevic, Slobodan Vukicevic
Opublikowane w: Bone, Numer 140, 2020, Strona(/y) 115551, ISSN 8756-3282
Wydawca: Elsevier BV
DOI: 10.1016/j.bone.2020.115551

Autologous bone graft substitute containing rhBMP6 within autologous blood coagulum and synthetic ceramics of different particle size determines the quantity and structural pattern of bone formed in a rat subcutaneous assay

Autorzy: Nikola Stokovic, Natalia Ivanjko, Igor Erjavec, Milan Milosevic, Hermann Oppermann, Larry Shimp, Kuber T. Sampath, Slobodan Vukicevic
Opublikowane w: Bone, Numer 141, 2020, Strona(/y) 115654, ISSN 8756-3282
Wydawca: Elsevier BV
DOI: 10.1016/j.bone.2020.115654

Long-term posterolateral spinal fusion in rabbits induced by rhBMP6 applied in autologous blood coagulum with synthetic ceramics

Autorzy: N. Stokovic, N. Ivanjko, M. Pecin, I. Erjavec, A. Smajlovic, M. Milesevic, S. Karlovic, H. Capak, Z. Vrbanac, D. Maticic, S. Vukicevic
Opublikowane w: Scientific reports, Numer 12, 2022, Strona(/y) 11649, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-022-14931-2

Biology of bone morphogenetic protein in bone repair and regeneration: A role for autologous blood coagulum as carrier

Autorzy: T. Kuber Sampath, Slobodan Vukicevic
Opublikowane w: Bone, Numer 141, 2020, Strona(/y) 115602, ISSN 8756-3282
Wydawca: Elsevier BV
DOI: 10.1016/j.bone.2020.115602

Recombinant Human BMP6 Applied Within Autologous Blood Coagulum Accelerates Bone Healing: Randomized Controlled Trial in High Tibial Osteotomy Patients

Autorzy: Catharina Chiari, Lovorka Grgurevic, Tatjana Bordukalo‐Niksic, Hermann Oppermann, Alexander Valentinitsch, Elena Nemecek, Kevin Staats, Markus Schreiner, Carmen Trost, Alexander Kolb, Franz Kainberger, Sanja Pehar, Milan Milosevic, Snjezana Martinovic, Mihaela Peric, T Kuber Sampath, Slobodan Vukicevic, Reinhard Windhager
Opublikowane w: Journal of Bone and Mineral Research, Numer 35/10, 2020, Strona(/y) 1893-1903, ISSN 0884-0431
Wydawca: American Society for Bone and Mineral Research
DOI: 10.1002/jbmr.4107

Bone morphogenetic proteins in fracture repair

Autorzy: Ivo Dumic-Cule, Mihaela Peric, Lucija Kucko, Lovorka Grgurevic, Marko Pecina, Slobodan Vukicevic
Opublikowane w: International Orthopaedics, Numer 42/11, 2018, Strona(/y) 2619-2626, ISSN 0341-2695
Wydawca: Springer Verlag
DOI: 10.1007/s00264-018-4153-y

Recombinant Human Bone Morphogenetic Protein 6 Delivered Within Autologous Blood Coagulum Restores Critical Size Segmental Defects of Ulna in Rabbits

Autorzy: Lovorka Grgurevic, Hermann Oppermann, Marko Pecin, Igor Erjavec, Hrvoje Capak, Martina Pauk, Sven Karlovic, Vera Kufner, Marija Lipar, Jadranka Bubic Spoljar, Tatjana Bordukalo-Niksic, Drazen Maticic, Mihaela Peric, Reinhard Windhager, T Kuber Sampath, Slobodan Vukicevic
Opublikowane w: JBMR Plus, Numer 3/5, 2019, Strona(/y) e10085, ISSN 2473-4039
Wydawca: American Society for Bone and Mineral Research
DOI: 10.1002/jbm4.10085

Autologous blood coagulum containing rhBMP6 induces new bone formation to promote anterior lumbar interbody fusion (ALIF) and posterolateral lumbar fusion (PLF) of spine in sheep

Autorzy: Lovorka Grgurevic, Igor Erjavec, Munish Gupta, Marko Pecin, Tatjana Bordukalo-Niksic, Nikola Stokovic, Drazen Vnuk, Vladimir Farkas, Hrvoje Capak, Milan Milosevic, Jadranka Bubic Spoljar, Mihaela Peric, Mirta Vuckovic, Drazen Maticic, Reinhard Windhager, Hermann Oppermann, T. Kuber Sampath, Slobodan Vukicevic
Opublikowane w: Bone, Numer 138, 2020, Strona(/y) 115448, ISSN 8756-3282
Wydawca: Elsevier BV
DOI: 10.1016/j.bone.2020.115448

Synthetic ceramic macroporous blocks as a scaffold in ectopic bone formation induced by recombinant human bone morphogenetic protein 6 within autologous blood coagulum in rats

Autorzy: Nikola Stokovic, Natalia Ivanjko, Marina Milesevic, Ivona Matic Jelic, Kristian Bakic, Viktorija Rumenovic, Hermann Oppermann, Larry Shimp, T. Kuber Sampath, Marko Pecina, Slobodan Vukicevic
Opublikowane w: International Orthopaedics, 2020, ISSN 0341-2695
Wydawca: Springer Verlag
DOI: 10.1007/s00264-020-04847-9

MolPharm/CABS 2018

Autorzy: Slobodan Vukicevic, Lovorka Grgurevic
Opublikowane w: Journal of Bone Oncology, Numer 13, 2018, Strona(/y) 11-54, ISSN 2212-1374
Wydawca: Elsevier GmbH
DOI: 10.1016/j.jbo.2018.07.009

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