A neuroprosthesis to restore the vagal-cardiac closed-loop connection after heart transplantation

Informacje na temat projektu

NeuHeart

Identyfikator umowy o grant: 824071

DOI

10.3030/824071

Projekt został zamknięty

Data podpisania przez KE 23 Października 2018

Data rozpoczęcia 1 Stycznia 2019

Data zakończenia 30 Czerwca 2023

Finansowanie w ramach

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Koszt całkowity

€ 4 983 465,00

Wkład UE

€ 4 983 465,00

Koordynowany przez

SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA
Italy

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Websites, patent fillings, videos etc. (1)

Workshop on ethics, law and policies for smart cardiac prostheses

Organization of a workshop on ethics law and policies for smart cardiac prostheses

Documents, reports (3)

Atlas of VN cardiac afferents

Results of the extensive study of the anatomy and functional units of the VN cardiac afferents

Final report on regulatory, ethical and legal issues

Analysis of all regulatory ethical and legal issues related to the development and use of the NeuHeart cardiac neuroprosthesis

Integrated protocol for biomarker autonomic function monitoring

Monitoring of circulating biomarkers related to cardiovascular VN activity

Publikacje

Peer reviewed articles (27)

Mapping the functional anatomy and topography of the cardiac autonomic innervation for selective cardiac neuromodulation using MicroCT

Autorzy: Bettina Kronsteiner, Lydia M Zopf, Patrick Heimel, Gunpreet Oberoi, Anne M Kramer, Paul Slezak, Wolfgang J Weninger, Bruno K Podesser, Attila Kiss, Francesco Moscato
Opublikowane w: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Wydawca: usanne: Frontiers Media S.A., 2013-
DOI: 10.3389/fcell.2022.968870

Accurate, Very Low Computational Complexity Spike Sorting Using Unsupervised Matched Subspace Learning

Autorzy: Zamani M, Sokolic J, Jiang D, Renna F, Rodrigues MRD, Demosthenous A
Opublikowane w: IEEE Trans Biomed Circuits Syst, Numer Apr;14(2):221-231, 2020, ISSN 1940-9990
Wydawca: IEEE
DOI: 10.1109/tbcas.2020.2969910

Time Stamp – A Novel Time-to-Digital Demodulation Method for Bioimpedance Implant Applications

Autorzy: Wu Y, Jiang D, Habibollahi M, Almarri N, Demosthenous A
Opublikowane w: IEEE Trans Biomed Circuits Syst, Numer Oct;14(5):997-1007, 2020, ISSN 1940-9990
Wydawca: IEEE
DOI: 10.1109/tbcas.2020.3012057

Recent Advances in Polymeric Drug Delivery Systems for Peripheral Nerve Regeneration

Autorzy: Bianchini M, Micera S, Redolfi Riva E.
Opublikowane w: Pharmaceutics, Numer 14;15(2):640, 2023, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15020640

Cardiovascular Response to Intraneural Right Vagus Nerve Stimulation in Adult Minipig

Autorzy: Agnesi F, Zinno C, Strauss I, Dushpanova A, Casieri V, Bernini F, Terlizzi D, Gabisonia K, Lionetti V, Micera S.
Opublikowane w: Neuromodulation: Technology at the Neural Interface, Numer 29:S1094-7159(23)00131-9, 2023, ISSN 1094-7159
Wydawca: Blackwell Publishing Inc.
DOI: 10.1016/j.neurom.2023.03.002

Progress and challenges of implantable neural interfaces based on nature-derived materials

Autorzy: Eugenio Redolfi Riva, Silvestro Micera
Opublikowane w: Bioelectronic Medicine, Numer 7/1, 2021, ISSN 2332-8886
Wydawca: BioMed Central Ltd
DOI: 10.1186/s42234-021-00067-7

Closed-Loop Vagus Nerve Stimulation for the Treatment of Cardiovascular Diseases: State of the Art and Future Directions

Autorzy: Ottaviani MM, Vallone F, Micera S, Recchia FA
Opublikowane w: Frontiers in Cardiovascular Medicine-Hypertension, 2022, ISSN 2297-055X
Wydawca: Frontiers Media SA
DOI: 10.3389/fcvm.2022.866957

A Fully Implantable Opto-Electro Closed-Loop Neural Interface for Motor Neuron Disease Studies

Autorzy: Liu F, Wu Y, Almarri N, Habibollahi M, Lancashire HT, Bryson B, Greensmith L, Jiang D, Demosthenous A.
Opublikowane w: IEEE Trans Biomed Circuits Syst, Numer Oct;16(5):752-765, 2022, ISSN 1940-9990
Wydawca: IEEE
DOI: 10.1109/tbcas.2022.3202026

Changes in Resting and Exercise Hemodynamics Early After Heart Transplantation: A Simulation Perspective

Autorzy: Max Haberbusch, Daniela De Luca, Francesco Moscato
Opublikowane w: Frontiers in Physiology, Numer 11, 2020, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.579449

A Goertzel Filter-Based System for Fast Simultaneous Multi-Frequency EIS

Autorzy: Regnacq L, Wu Y, Neshatvar N, Jiang D and Demosthenous A
Opublikowane w: IEEE Transactions on Circuits and Systems II: Express Briefs, Numer 68(9): 3133-3137, 2021, ISSN 1558-3791
Wydawca: IEEE
DOI: 10.1109/tcsii.2021.3092069

Understanding the heart-brain axis response in COVID-19 patients: A suggestive perspective for therapeutic development

Autorzy: Lionetti V, Bollini S, Coppini R, Gerbino A, Ghigo A, Iaccarino G, Madonna R, Mangiacapra F, Miragoli M, Moccia F, Munaron L, Pagliaro P, Parenti A, Pasqua T, Penna C, Quaini F, Rocca C, Samaja M, Sartiani L, Soda T, Tocchetti CG, Angelone T
Opublikowane w: Pharmacol Res, Numer 168:105581, 2021, Strona(/y) 1-12, ISSN 1096-1186
Wydawca: Elsevier
DOI: 10.1016/j.phrs.2021.105581

Polysaccharide Layer-by-Layer Coating for Polyimide-Based Neural Interfaces

Autorzy: Redolfi Riva E, D'Alessio A, Micera S
Opublikowane w: Micromachines (Basel), 2022, ISSN 2072-666X
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi13050692

Quantification of paravalvular leaks associated with TAVI implants using 4D MRI in an aortic root phantom made possible by the use of 3D printing

Autorzy: Philipp Aigner, Eleonora Sella Bart, Sebastiano Panfili, Tito Körner, Markus Mach, Martin Andreas, Markus Königshofer, Simone Saitta, Alberto Redaelli, Albrecht Schmid, Francesco Moscato
Opublikowane w: Frontiers in Cardiovascular Medicine, 2023, ISSN 2297-055X
Wydawca: Lausanne: Frontiers Media S.A., 2014-
DOI: 10.3389/fcvm.2023.1083300

Closed-loop vagus nerve stimulation for heart rate control evaluated in the Langendorff-perfused rabbit heart

Autorzy: Max Haberbusch; Bettina Kronsteiner; Anne-Margarethe Kramer; Attila Kiss; Bruno K. Podesser; Francesco Moscato
Opublikowane w: Crossref, Numer 5, 2022, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-022-23407-2

A Numerical Model of the Acute Cardiac Effects Provoked by Cervical Vagus Nerve Stimulation

Autorzy: Max Haberbusch, Silvia Frullini, Francesco Moscato
Opublikowane w: IEEE Transactions on Biomedical Engineering, 2022, ISSN 0018-9294
Wydawca: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tbme.2021.3102416

Late plasma exosome microRNA-21-5p depicts magnitude of reverse ventricular remodeling after early surgical repair of primary mitral valve regurgitation

Autorzy: Pizzino F, Furini G, Casieri V, Mariani M, Bianchi G, Storti S, Chiappino D, Maffei S, Solinas M, Aquaro GD, Lionetti V.
Opublikowane w: Front Cardiovasc Med, Numer 29;9:943068, 2022, Strona(/y) 1-21, ISSN 2297-055X
Wydawca: Frontiers
DOI: 10.3389/fcvm.2022.943068

Simultaneous decoding of cardiovascular and respiratory functional changes from pig intraneural vagus nerve signals

Autorzy: Fabio Vallone, Matteo Maria Ottaviani, Francesca Dedola, Annarita Cutrone, Simone Romeni, Adele Macrí Panarese, Fabio Bernini, Marina Cracchiolo, Ivo Strauss, Khatia Gabisonia, Nikoloz Gorgodze, Alberto Mazzoni, Fabio A Recchia, Silvestro Micera
Opublikowane w: Journal of Neural Engineering, Numer 18/4, 2021, Strona(/y) 0460a2, ISSN 1741-2560
Wydawca: Institute of Physics Publishing
DOI: 10.1088/1741-2552/ac0d42

A Multi-Channel Stimulator With High-Resolution Time-to-Current Conversion for Vagal-Cardiac Neuromodulation

Autorzy: Wu Y, Jiang D, Demosthenous A
Opublikowane w: IEEE Trans Biomed Circuits Syst, Numer Dec;15(6):1186-1195, 2021, ISSN 1940-9990
Wydawca: IEEE
DOI: 10.1109/tbcas.2021.3139996

Fiber Bragg Gratings for Medical Applications and Future Challenges: A Review

Autorzy: Daniela Lo Presti, Carlo Massaroni, Catia Sofia Jorge Leitao, Maria De Fatima Domingues, Marzhan Sypabekova, David Barrera, Ignazio Floris, Luca Massari, Calogero Maria Oddo, Salvador Sales, Iulian Ioan Iordachita, Daniele Tosi, Emiliano Schena
Opublikowane w: IEEE Access, Numer 8, 2020, Strona(/y) 156863-156888, ISSN 2169-3536
Wydawca: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.1109/access.2020.3019138

Implantable Neural Interfaces and Wearable Tactile Systems for Bidirectional Neuroprosthetics Systems

Autorzy: Annarita Cutrone, Silvestro Micera
Opublikowane w: Advanced Healthcare Materials, Numer 8/24, 2019, Strona(/y) 1801345, ISSN 2192-2640
Wydawca: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201801345

A novel ex-vivo isolated rabbit heart preparation to explore the cardiac effects of cervical and cardiac vagus nerve stimulation

Autorzy: Bettina Kronsteiner, Max Haberbusch, Philipp Aigner, Anne-Margarethe Kramer, Patrick M. Pilz, Bruno K. Podesser, Attila Kiss, Francesco Moscato
Opublikowane w: Scientific Reports, 2023, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-023-31135-4

A lightweight learning-based decoding algorithm for intraneural vagus nerve activity classification in pigs

Autorzy: Pollina L, Vallone F, Ottaviani MM, Strauss I, Carlucci L, Recchia FA, Micera S, Moccia S
Opublikowane w: Journal of Neural Engineering, 2022, Strona(/y) 19 046033, ISSN 1741-2560
Wydawca: Institute of Physics Publishing
DOI: 10.1088/1741-2552/ac84ab

Implantable Fiber Bragg Grating Sensor for Continuous Heart Activity Monitoring: Ex-Vivo and In-Vivo Validation

Autorzy: Ferraro D, D’Alesio G, Camboni D, Zinno C, Costi L, Haberbusch M, Aigner P, Maw M, Schlöglhofer, Unger E, Aliperta A, Bernini F, Casieri V, Terlizzi D, Giudetti G, Carpaneto J, Pedrizzetti G, Micera S, Lionetti V, Moscato F, Massari L, Oddo CM
Opublikowane w: IEEE Sensors Journal, Numer 21(13), 2021, Strona(/y) 14051-14059, ISSN 1558-1748
Wydawca: Institute of Electrical and Electronic Engineers
DOI: 10.1109/jsen.2021.3056530

Bioelectronic medicine for the autonomic nervous system: clinical applications and perspectives

Autorzy: Marina Cracchiolo, Matteo Maria Ottaviani, Alessandro Panarese, Ivo Strauss, Fabio Vallone, Alberto Mazzoni, Silvestro Micera
Opublikowane w: Journal of Neural Engineering, Numer 18/4, 2021, Strona(/y) 041002, ISSN 1741-2560
Wydawca: Institute of Physics Publishing
DOI: 10.1088/1741-2552/abe6b9

A method to establish functional vagus nerve topography from electro-neurographic spontaneous activity

Autorzy: Pitzus A, Romeni S, Vallone F, Micera S
Opublikowane w: Patterns, Numer 3(11):100615, 2022, ISSN 2666-3899
Wydawca: Cell Press Elsevier Inc.
DOI: 10.1016/j.patter.2022.100615

Short-Range Quality-Factor Modulation (SQuirM) for Low Power High Speed Inductive Data Transfer

Autorzy: Schormans M, Jiang D, Valente V and Demosthenous A
Opublikowane w: IEEE Transactions on Circuits and Systems I: Regular Papers, Numer 66(9):3254-3265, 2019, ISSN 2158-1525
Wydawca: IEEE
DOI: 10.1109/tcsi.2019.2922124

An Implantable Phase Locked Loop MEMS-Based Readout System for Heart Transplantation

Autorzy: Neshatvar N, Schormans M, Jiang D, Schmitt S, Detemple P and Demosthenous A
Opublikowane w: IEEE Transactions on Circuits and Systems II: Express Briefs, Numer 69(10):4168-4172, 2022, ISSN 1558-3791
Wydawca: IEEE
DOI: 10.1109/tcsii.2022.3190796

Prawa własności intelektualnej

Patent (1)

INTRAFASCICULAR ELECTRODE IMPLANT

Numer wniosku/publikacji: 17 791738
Data: 2017-09-29
Wnioskodawca/wnioskodawcy: SENSARS NEUROPROSTHETICS SARL