At the end of the end of the project the consortium has advanced scientific knowledge and neurotechnologies by:
- Developing fabrication methods to realize plasmonic structures on tapered fibers (including a wide field-of-view two photon lithography system)
- Implementing novel numerical design of the plasmonic structures
- Implementing Novel numerical methods to estimate electromagnetic field on the edge of optical fibers
- Developing optical methods to obtain spatial resolution for both flat-cleaved and tapered fibers-based endoscopes
- Implementingf Raman Systems in neuroscience and cancer neuroscience labs and their combination with electrophysiology system
- Developing models of diseases to obtain simultaneous Surface Enchanted Raman Signals, optical readout of neural activity and electrophysiology
- Developing of models of diseases to investigate the permeability of the blood-brain-barrier
- Engineering Light–Matter Interactions on the Nonplanar Surface of Tapered Optical Fibers, proposing Plasmonics on a Neural Implant
- Implementing Holographic Manipulation of Nanostructured Fiber Optics Enables Spatially-Resolved, Reconfigurable Optical Control of Plasmonic Local Field Enhancement and SERS
- Obtaining SERS Detection of Neurotransmitters through Gold-Nanoislands-Decorated Tapered Optical Fibers with Sub-10 nm Gaps, with a limit of detection as low as 10-6 M
- Developing Machine learning methods to identify experimental brain metastasis subtypes based on their influence on neural circuits
Obtained so far have been published in peer-reviewed scientific journals and presented to international scientific conferences. NanoBRIGTH got ample coverage in press media, radio and television of Italy, Spain and France along this first year.
