Periodic Reporting for period 1 - OMECRY (Organic Mesocrystals: Formation and controlling of oriented nanoparticles of molecular solids for drug development)
Okres sprawozdawczy: 2019-10-01 do 2021-09-30
The ibuprofen was chosen as model compound since this solubility is low as about 21 mg/L at 25 °C. Based on experimental methods and in situ studies, this action concludes that the high supersaturation with dispersed particles at the initial stage of crystallization and suitable additives are required to form ibuprofen mesocrystals. The experimental observation of liquid-liquid phase separation was apparent in pharmaceutical solids with low melting point and in situ studies confirmed that the dense liquid phase is not amorphous, and their molecular interactions are different than dimer of ibuprofen due to closely packed molecular environment. The dissolution of ibuprofen mesocrystals has enhanced compared with their classical grown single crystals.