Cel The proposed research will investigate the involvement of mammalian sterile 20-like kinase-3b (Mst-3b) in central nervous system (CNS) regeneration. It has previously been shown that the purine nucleoside inosine stimulates extensive axon outgrowth from certain types of neurons in culture and from injured brain pathways in vivo, leading to improved behavioural outcome.Pilot experiments in the outgoing host institution suggest that the target of inosine's actions is the protein kinase Mst-3b, and that suppressing Mst-3b levels or functioning inhibits the generation of neurites in culture.The main aims of this study are to investigate the role of Mst-3b in optic nerve regeneration in vivo and to investigate whether signalling through this kinase regulates the expression of a constellation of regeneration-associated genes. This project will use innovative, cutting-edge techniques such as adeno-associated virus transfection and microarray to alter/assess gene expression in vivo.The aims of this fellowship are- to advance our understanding of the basic mechanisms underlying regenerative success/failure in the CNS,- training of the fellow Barbara Lorber to become an independent scientist leading her own research group in Europe, and- to establish a, potentially long term, scientific collaboration between the outgoing host institution (Children's Hospital Boston (affiliated to Harvard Medical School), USA) and the return host institution (University of Birmingham, UK). Dziedzina nauki natural sciencesbiological sciencesneurobiologymedical and health sciencesclinical medicineophthalmologyglaucomanatural sciencesbiological sciencescell biologycell signalingnatural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesbasic medicineneurologystroke Słowa kluczowe Central nervous system regeneration Functional genomics Mst-3b Rodent Program(-y) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Temat(-y) MOBILITY-2.2 - Marie Curie Outgoing International Fellowships (OIF) Zaproszenie do składania wniosków FP6-2002-MOBILITY-6 Zobacz inne projekty w ramach tego zaproszenia System finansowania OIF - Marie Curie actions-Outgoing International Fellowships Koordynator THE UNIVERSITY OF BIRMINGHAM Wkład UE Brak danych Adres Edgbaston BIRMINGHAM Zjednoczone Królestwo Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (1) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko CHILDREN'S HOSPITAL BOSTON (HARVARD MEDICAL SCHOOL) Stany Zjednoczone Wkład UE Brak danych Adres 300 Longwood Avenue BOSTON Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych
