Since January 2020, the AIMed Innovative Training Network (ITN) has developed antibiotic-free solutions to prevent infections in orthopaedic implants. The consortium of 12 beneficiaries and 7 partner organisations trained 15 Early-Stage Researchers (ESRs), each completing a PhD within a coordinated programme on antimicrobial materials, coatings, and standards.
Scientific progress: Over 20 novel antimicrobial peptides (AMPs) inspired by human defensins and cathelicidins were designed and tested. Two lead candidates showed strong antibacterial activity and low toxicity. Metals, ceramics, and polymers were functionalised with these peptides or doped with Ag, Cu, and Zn ions, producing coatings that combined antimicrobial protection with biocompatibility. Biomimetic calcium phosphate coatings and laser-patterned / 3D-printed surfaces demonstrated dual antibacterial and osteogenic effects, achieving over 95 % bacterial inhibition.
Testing and standardisation: Extensive antibacterial and biocompatibility studies validated the new materials. AIMed partners contributed to ISO TC 150 and ASTM F04 committees, defining international testing protocols for antimicrobial biomaterials.
Training and dissemination: All ESRs received multidisciplinary training, completing network schools, workshops, and industrial secondments. Despite pandemic restrictions, the programme was delivered through hybrid formats. The network produced over 25 peer-reviewed publications, several patent-relevant findings, and broad dissemination at major scientific conferences.
Impact: AIMed demonstrated that bio-inspired peptides, ion-doped ceramics, and laser-engineered surfaces can prevent bacterial colonisation without antibiotics. Its results advance the EU’s fight against antimicrobial resistance, establish testing standards for safer implants, and provide Europe with a new generation of researchers driving innovation in biomedical materials.
