Doctorate School in Integrated Genomics Research

Informacje na temat projektu

INTEGRATE

Identyfikator umowy o grant: 945385

DOI

10.3030/945385

Projekt został zamknięty

Data podpisania przez KE 10 Kwietnia 2020

Data rozpoczęcia 1 Września 2020

Data zakończenia 31 Sierpnia 2026

Finansowanie w ramach

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Koszt całkowity

€ 4 339 200,00

Wkład UE

€ 2 169 600,00

Koordynowany przez

UNIVERSITY OF GALWAY
Ireland

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (2)

Link to Euraxess website for the first call for proposals

Project Officer informed on publishing each call for proposals, by sending the link to the Euraxess website and a screen shot of the related call announcement.

Link to Euraxess website for the second call for proposals

Project Officer informed on publishing each call for proposals by sending the link to the Euraxess website and a screen shot of the related call announcement

Publikacje

Peer reviewed articles (35)

Small Extracellular Vesicles Secreted by Cisplatin-Resistant Neuroblastoma Cells Increase Lactate Secretion and Alter Metabolic Pathways in Primary Human Umbilical Vein Endothelial Cells (HUVECs)

Autorzy: Thomas Frawley, Lin Ma, Muhammad Zainul Arifin, Dan Wu, Alysia Scott, Brenton Cavanagh, Donal F. O’Shea, Vadim Zhernovkov, Mi Liu, Marco P. Monopoli, Olga Piskareva
Opublikowane w: Journal of Personalized Medicine, Numer 15, 2025, Strona(/y) 584, ISSN 2075-4426
Wydawca: MDPI AG
DOI: 10.3390/jpm15120584

Multiomic Sequencing Reveals Distinctive Gene Expression and Epigenetic Alterations Associated With Primary Sclerosing Cholangitis Development in Treatment-Naïve Pediatric Ulcerative Colitis

Autorzy: Alejandra Rodriguez-Sosa, Ololade Lawal, Ciaran McDonnell, Luke Grant, John O’Brien, Muhammad Ali, Ian Stephens, Grainne Kirwan, Flavia Genua, Alexander Kel, Anna Dominik, Roisin Stack, Gregory Yochum, Michael McDermot, Glen Doherty, Seamus Hussey, Sudipto Das
Opublikowane w: Gastro Hep Advances, 2025, ISSN 2772-5723
Wydawca: Elsevier Inc.
DOI: 10.1016/j.gastha.2024.11.002

Identification of unique rectal cancer-specific subtypes

Autorzy: Batuhan Kisakol, Anna Matveeva, Manuela Salvucci, Alexander Kel, Elizabeth McDonough, Fiona Ginty, Daniel B. Longley, Jochen H. M. Prehn
Opublikowane w: British Journal of Cancer, Numer 130, 2024, Strona(/y) 1809-1818, ISSN 0007-0920
Wydawca: Nature Publishing Group
DOI: 10.1038/s41416-024-02656-0

Comprehensive Analysis of Seasonal and Geographical Variation in UVB Radiation Relevant for Vitamin D Production in Europe

Autorzy: Tarinee Khanna, Rasha Shraim, Masa Zarkovic, Michiel van Weele, Jos van Geffen, and Lina Zgaga
Opublikowane w: Nutrients, Numer Vol. 14, No. 23, 2022, Strona(/y) 5189, ISSN 2072-6643
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu14235189

Ancient genomes reveal demographic trajectories during the Classic Maya period

Autorzy: Madeleine Murray, Seiichi Nakamura, Melvin Fuentes, Rolando Canizales, Omar Talavera, Salvador Varela, Zoila Madrid, Carlos Carbajal, Masahiro Ogawa, Minoru Yoneda, Lara M. Cassidy, Takashi Gakuhari, Shigeki Nakagome
Opublikowane w: Current Biology, Numer 35, 2025, Strona(/y) 2709-2719.e5, ISSN 0960-9822
Wydawca: Cell Press
DOI: 10.1016/j.cub.2025.05.002

Spatial transcriptomic analysis reveals local effects of intratumoral fusobacterial infection on DNA damage and immune signaling in rectal cancer

Autorzy: William P. Duggan, Batuhan Kisakol, Ina Woods, Mohammedreza Azimi, Heiko Dussmann, Joanna Fay, Tony O’Grady, Barry Maguire, Ian S. Reynolds, Manuela Salvucci, Daniel J. Slade, Deborah A. McNamara, John P. Burke, Jochen H.M. Prehn
Opublikowane w: Gut Microbes, Numer 16, 2024, ISSN 1949-0984
Wydawca: Taylor & Francis
DOI: 10.1080/19490976.2024.2350149

Increased Fusobacterium tumoural abundance affects immunogenicity in mucinous colorectal cancer and may be associated with improved clinical outcome

Autorzy: William P. Duggan, Manuela Salvucci, Batuhan Kisakol, Andreas U. Lindner, Ian S. Reynolds, Heiko Dussmann, Joanna Fay, Tony O’Grady, Daniel B. Longley, Fiona Ginty, Elizabeth Mc Donough, Daniel J. Slade, John P. Burke, Jochen H. M. Prehn
Opublikowane w: Journal of Molecular Medicine, Numer 101, 2023, Strona(/y) 829-841, ISSN 0946-2716
Wydawca: Springer Verlag
DOI: 10.1007/s00109-023-02324-5

Direct cell interactions potentially regulate transcriptional programmes that control the responses of high grade serous ovarian cancer patients to therapy

Autorzy: Sodiq A. Hameed, Walter Kolch, Donal J. Brennan, Vadim Zhernovkov
Opublikowane w: Scientific Reports, Numer 15, 2025, Strona(/y) 14484, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-025-98463-5

Strain-level variation among vaginal Lactobacillus crispatus and Lactobacillus iners as identified by comparative metagenomics

Autorzy: Sai Ravi Chandra Nori, Calum J. Walsh, Fionnuala M. McAuliffe, Rebecca L. Moore, Douwe Van Sinderen, Conor Feehily, Paul D. Cotter
Opublikowane w: npj Biofilms and Microbiomes, Numer 11, 2025, ISSN 2055-5008
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s41522-025-00682-1

Overview of Molecular Diagnostics in Irish Clinical Oncology

Autorzy: Tyler Medina, Seán O. Hynes, Maeve Lowery, Patrick Gillespie, Walter Kolch, Cathal Seoighe
Opublikowane w: HRB Open Research, Numer 7, 2025, Strona(/y) 16, ISSN 2515-4826
Wydawca: F1000 Research Ltd
DOI: 10.12688/hrbopenres.13822.1

Non-Negative matrix factorization combined with kernel regression for the prediction of adverse drug reaction profiles

Autorzy: Yezhao Zhong, Cathal Seoighe, Haixuan Yang
Opublikowane w: Bioinformatics Advances, Numer 4, 2024, Strona(/y) vbae009, ISSN 2635-0041
Wydawca: Oxford University Press (OUP)
DOI: 10.1093/bioadv/vbae009

Integrated multiplex analysis of cell death regulators in stage II colorectal cancer suggests patients with ‘persister’ cell profiles fail to benefit from adjuvant chemotherapy

Autorzy: Sanghee Cho, Elizabeth McDonough, John Graf, Jinru Shia, Canan Firat, Nil Urganci, Christine Surrette, Andreas Lindner, Manuela Salvucci, Anna Matveeva, Batuhan Kisakol, Anthony O’Grady, Mohammadreza Azimi, John P Burke, Deborah A McNamara, Simon McDade, Daniel B Longley, Jochen HM Prehn, Fiona Ginty
Opublikowane w: BMJ Oncology, Numer 3, 2024, Strona(/y) e000362, ISSN 2752-7948
Wydawca: BMJ
DOI: 10.1136/bmjonc-2024-000362

Prevalence and determinants of profound vitamin D deficiency (25-hydroxyvitamin D <10 nmol/L) in the UK Biobank and potential implications for disease association studies

Autorzy: Rasha Shraim, Margaret M. Brennan, Jos van Geffen, Lina Zgaga
Opublikowane w: The Journal of Steroid Biochemistry and Molecular Biology, 2025, ISSN 1879-1220
Wydawca: Elsevier Ltd.
DOI: 10.1016/j.jsbmb.2025.106737

Gene essentiality in cancer is better predicted by mRNA abundance than by gene regulatory network-inferred activity

Autorzy: Cosmin Tudose, Jonathan Bond, Colm J Ryan
Opublikowane w: NAR Cancer, Numer 5, 2023, ISSN 2632-8674
Wydawca: Oxford University Press (OUP)
DOI: 10.1093/narcan/zcad056

SATB2 Expression Affects Chemotherapy Metabolism and Immune Checkpoint Gene Expression in Colorectal Cancer

Autorzy: Barry Maguire, Batuhan Kisakol, Jochen H.M. Prehn, John P. Burke
Opublikowane w: Clinical Colorectal Cancer, Numer 24, 2026, Strona(/y) 129-134.e7, ISSN 1533-0028
Wydawca: Cancer Information Group
DOI: 10.1016/j.clcc.2024.12.004

Multiplexed Immunofluorescence Imaging Reveals an Immune-Rich Tumor Microenvironment in Mucinous Rectal Cancer Characterized by Increased Lymphocyte Infiltration and Enhanced Programmed Cell Death Protein 1 Expression

Autorzy: William P. Duggan, Batuhan Kisakol, Emer O’Connell, Anna Matveeva, Tony O’Grady, Elizabeth McDonough, Andreas U. Lindner, Deborah McNamara, Daniel Longley, Fiona Ginty, John P. Burke, Jochen H.M. Prehn
Opublikowane w: Diseases of the Colon &amp; Rectum, Numer 66, 2025, Strona(/y) 914-922, ISSN 0012-3706
Wydawca: Springer Verlag
DOI: 10.1097/dcr.0000000000002624

Cell-cell interactome of the hematopoietic niche and its changes in acute myeloid leukemia

Autorzy: Sarah Ennis, Alessandra Conforte, Eimear O’Reilly, Javid Sabour Takanlu, Tatiana Cichocka, Sukhraj Pal Dhami, Pamela Nicholson, Philippe Krebs, Pilib Ó Broin, Eva Szegezdi
Opublikowane w: iScience, Numer 26, 2026, Strona(/y) 106943, ISSN 2589-0042
Wydawca: Elsevier BV
DOI: 10.1016/j.isci.2023.106943

Targeting synthetic lethal paralogs in cancer

Autorzy: Colm J. Ryan, Ishan Mehta, Narod Kebabci, David J. Adams
Opublikowane w: Trends in Cancer, Numer 9, 2023, Strona(/y) 397-409, ISSN 2405-8033
Wydawca: Elsevier Inc.
DOI: 10.1016/j.trecan.2023.02.002

CCPlotR: an R package for the visualization of cell–cell interactions

Autorzy: Sarah Ennis, Pilib Ó Broin, Eva Szegezdi
Opublikowane w: Bioinformatics Advances, Numer 3, 2023, Strona(/y) vbad130, ISSN 2635-0041
Wydawca: Oxford University Press (OUP)
DOI: 10.1093/bioadv/vbad130

Genome-wide gene-environment interaction study uncovers 162 vitamin D status variants using a precise ambient UVB measure

Autorzy: Rasha Shraim, Maria Timofeeva, Cathy Wyse, Jos van Geffen, Michiel van Weele, Roman Romero-Ortuno, Lorna M. Lopez, Marcus E. Kleber, Stefan Pilz, Winfried März, Benjamin S. Fletcher, James F. Wilson, Evropi Theodoratou, Malcolm G. Dunlop, Ross McManus, Lina Zgaga
Opublikowane w: Nature Communications, Numer 16, 2025, Strona(/y) 10774, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-025-65820-x

Effect of Immunosuppression on the Immune Response to SARS-CoV-2 Infection and Vaccination

Autorzy: Emma J. Leacy, Jia Wei Teh, Aoife M. O’Rourke, Gareth Brady, Siobhan Gargan, Niall Conlon, Jennifer Scott, Jean Dunne, Thomas Phelan, Matthew D. Griffin, Julie Power, Aoife Mooney, Aifric Naughton, Rachel Kiersey, Mary Gardiner, Caroline O’Brien, Ronan Mullan, Rachael Flood, Michael Clarkson, Liam Townsend, Michelle O’Shaughnessy, Adam H. Dyer, Barry Moran, Jean M. Fletcher, Lina Zgaga, Mark
Opublikowane w: International Journal of Molecular Sciences, Numer 25, 2025, Strona(/y) 5239, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25105239

A compendium of synthetic lethal gene pairs defined by extensive combinatorial pan-cancer CRISPR screening

Autorzy: Victoria Harle, Victoria Offord, Birkan Gökbağ, Lazaros Fotopoulos, Thomas Williams, Diana Alexander, Ishan Mehta, Nicola A. Thompson, Rebeca Olvera-León, Stefan Peidli, Vivek Iyer, Emanuel Gonçalves, Narod Kebabci, Barbara De Kegel, Joris van de Haar, Lang Li, Colm J. Ryan, David J. Adams
Opublikowane w: Genome Biology, Numer 26, 2025, Strona(/y) 284, ISSN 1474-760X
Wydawca: Springer Science and Business Media LLC
DOI: 10.1186/s13059-025-03737-w

Consistent asymmetry in DNA damage artefacts across target regions in exome sequencing data

Autorzy: Tyler D Medina, Declan Bennett, Cathal Seoighe
Opublikowane w: NAR Genomics and Bioinformatics, Numer 7, 2025, ISSN 2631-9268
Wydawca: Oxford University Press (OUP)
DOI: 10.1093/nargab/lqaf120

Maximizing Insights from Longitudinal Epigenetic Age Data: Simulations, Applications, and Practical Guidance

Autorzy: Anna Großbach, Matthew J. Suderman, Anke Hüls, Alexandre A. Lussier, Andrew D.A.C. Smith, Esther Walton, Erin C. Dunn, Andrew J. Simpkin
Opublikowane w: Clinical Epigenetics, Numer 16, 2024, ISSN 1868-7083
Wydawca: BioMed Central Ltd
DOI: 10.21203/rs.3.rs-4482915/v1

Gene-Environment Interactions in Vitamin D Status and Sun Exposure: A Systematic Review with Recommendations for Future Research

Autorzy: Rasha Shraim, Conor MacDonnchadha, Lauren Vrbanic, Ross McManus, Lina Zgaga
Opublikowane w: Nutrients, Numer 14, 2022, Strona(/y) 2735, ISSN 2072-6643
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu14132735

Systematic review on gene–sun exposure interactions in skin cancer

Autorzy: Rasha Shraim, Mohamed Ziad Farran, George He, Jelena Marunica Karsaj, Lina Zgaga, Ross McManus
Opublikowane w: Molecular Genetics &amp; Genomic Medicine, Numer 11, 2023, ISSN 2324-9269
Wydawca: Wiley Periodicals LLC
DOI: 10.1002/mgg3.2259

Tumour mutations in long noncoding RNAs enhance cell fitness

Autorzy: Roberta Esposito, Andrés Lanzós, Tina Uroda, Sunandini Ramnarayanan, Isabel Büchi, Taisia Polidori, Hugo Guillen-Ramirez, Ante Mihaljevic, Bernard Mefi Merlin, Lia Mela, Eugenio Zoni, Lusine Hovhannisyan, Finn McCluggage, Matúš Medo, Giulia Basile, Dominik F. Meise, Sandra Zwyssig, Corina Wenger, Kyriakos Schwarz, Adrienne Vancura, Núria Bosch-Guiteras, Álvaro Andrades, Ai Ming Tham, Michae
Opublikowane w: Nature Communications, Numer 14, 2023, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-023-39160-7

Statistical power in vitamin D randomized control trials investigating biomarkers as continuous outcomes

Autorzy: Lina Zgaga, Rasha Shraim, Elizabeth Bolger, Jason Wyse
Opublikowane w: The Journal of Steroid Biochemistry and Molecular Biology, Numer 09600760, 2022, ISSN 0960-0760
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.jsbmb.2022.106148

Functional identification of <i>cis</i> -regulatory long noncoding RNAs at controlled false discovery rates

Autorzy: Bhavya Dhaka, Marc Zimmerli, Daniel Hanhart, Mario B Moser, Hugo Guillen-Ramirez, Sanat Mishra, Roberta Esposito, Taisia Polidori, Maro Widmer, Raquel García-Pérez, Marianna Kruithof-de Julio, Dmitri Pervouchine, Marta Melé, Panagiotis Chouvardas, Rory Johnson
Opublikowane w: Nucleic Acids Research, Numer 52, 2024, Strona(/y) 2821-2835, ISSN 0305-1048
Wydawca: Oxford University Press
DOI: 10.1093/nar/gkae075

Systematic prioritisation of context-specific paralog pair vulnerabilities in cancer

Autorzy: Narod Daldal, Hamda B. Ajmal, David J. Adams, Colm J. Ryan
Opublikowane w: Genome Medicine, Numer Published 12 September 2026, 2026, Strona(/y) N/A, ISSN 1756-994X
Wydawca: BioMed Central
DOI: 10.1186/s13073-026-01759-y

The association between epigenetic ageing from childhood to early adulthood and psychotic-like experiences in early adulthood

Autorzy: Zoe Hart, Anna Großbach, Andrew J Simpkin, Esther Walton
Opublikowane w: Psychological Medicine, Numer 55, 2026, Strona(/y) Article e182, pp. 1–9, ISSN 0033-2917
Wydawca: Cambridge University Press
DOI: 10.1017/s003329172510055x

Technical variability across the 450K, EPICv1, and EPICv2 DNA methylation arrays: lessons learned for clinical and longitudinal studies

Autorzy: Alexandre A. Lussier, Isabel K. Schuurmans, Anna Großbach, Julie Maclsaac, Kristy Dever, Nastassja Koen, Heather J. Zar, Dan J. Stein, Michael S. Kobor, Erin C. Dunn
Opublikowane w: Clinical Epigenetics, Numer 16, 2024, Strona(/y) 166, ISSN 1868-7083
Wydawca: Springer Science and Business Media LLC
DOI: 10.1186/s13148-024-01761-4

Ambient ultraviolet-B radiation, supplements and other factors interact to impact vitamin D status differently depending on ethnicity: A cross-sectional study

Autorzy: Margaret M. Brennan, Jos van Geffen, Michiel van Weele, Lina Zgaga, Rasha Shraim
Opublikowane w: Clinical Nutrition, Numer 43, 2024, Strona(/y) 1308-1317, ISSN 0261-5614
Wydawca: Churchill Livingstone
DOI: 10.1016/j.clnu.2024.04.006

BTLA and PD-1 signals attenuate TCR-mediated transcriptomic changes

Autorzy: Muhammad Zainul Arifin, Judith Leitner, Donagh Egan, Petra Waidhofer-Söllner, Walter Kolch, Vadim Zhernovkov, Peter Steinberger
Opublikowane w: iScience, Numer 27, 2025, Strona(/y) 110253, ISSN 2589-0042
Wydawca: Elsevier Inc.
DOI: 10.1016/j.isci.2024.110253

A novel TCF3::PIK3R1 fusion linked to decreased PI3K-AKT signalling activity in paediatric B-acute lymphoblastic leukaemia

Autorzy: Emma Grady, Sharmila Biswas, Tânia Dias, Peter McCarthy, Cosmin Tudose, David Betts, Andrea Malone, Jonathan Bond
Opublikowane w: British Journal of Haematology, Numer 205, 2024, ISSN 1365-2141
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1111/bjh.19587

Non-peer reviewed articles (4)

A predicted cancer dependency map for paralog pairs

Autorzy: Narod Kebabci, Hamda Ajmal, David J. Adams, Colm J. Ryan
Opublikowane w: BioRxiv, Numer Posted 19 January 2026; Version 1, 2026, Strona(/y) N/A, ISSN 0000-0000
Wydawca: Cold Spring Harbor Laboratory
DOI: 10.64898/2026.01.19.700065

Pan-cancer discovery of driver mutations in long noncoding RNAs reveals widespread functional rewiring of RNA regulatory elements

Autorzy: Sunandini Ramnarayanan, Roofiya Koya, Marta Soszynska-Jozwiak, Marta Szabat, Jack Roban, Sarang Bhutada, Bhavya Dhaka, Tilman Schaefer, Ai Ming Tham, Hugo A. Guillen Ramirez, Francesca Alessandroni, Michela Coan, Artem Baranovskii, Lambert Moyon, Annalisa Marsico, Colm Ryan, Richard S Houlston, Ryszard Kierzek, Elzbieta Kierzek, Rory Johnson
Opublikowane w: BioRxiv, Numer Posted 12 June 2026, 2026, Strona(/y) N/A, ISSN 0000-0000
Wydawca: openRxiv
DOI: 10.64898/2026.06.10.730876

HyperMap: An Efficient Framework for Transferring Perturbation Responses Across Diverse Biological Contexts

Autorzy: Bhavya Dhaka, Jiahao Gao, Trey Ideker
Opublikowane w: BioRxiv, Numer Posted 27 April 2026; Version 1, 2026, Strona(/y) N/A, ISSN 0000-0000
Wydawca: openRxiv, Cold Spring Harbor Laboratories
DOI: 10.64898/2026.04.23.720505

How philosophy is making me a better scientist

Autorzy: Rasha Shraim
Opublikowane w: Nature, Numer 23 April 2021, 2023, Strona(/y) N/A, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/d41586-021-01103-x