Biogenic Organotropic Wetsuits

Rezultaty

Promotional material

First version of the promotional material newsletters flyer videos video news release

Second promotional material

Second version of the promotional material newsletters flyer videos video news release

Website, social network profiles and CMS guide

Project web site and social network profiles CMS guide for all partners

First report on C&D activities

First report on CD activities

Functionalization of EVs

Setting up and validation of strategy to attach different proteinsantibodies or sugars to target cells

SOPs for synthesis of single-core magnetite MBDs

Standard Operating Procedure SOPs on single core magnetite MBDs SPIONS synthesis

Project management handbook

CSGI will produce a project handbook for project management and quality assurance It will define the guidelines for reporting and internal procedures

SOPs for synthesis of multi-core magnetite MBDs

SOPs on multicore magnetite MBDs

SOPs for derivatization of multi-core magnetite MBDs

SOPs on derivatized MBDs SPMbeads functionalization

SOPs for derivatization of single-core magnetite MBDs

SOPs on derivatized MBDs SPIONS functionalization

Project Exploitation and Dissemination Plan

First version of the project Exploitation and Dissemination Plan PEDR

Updated Project Exploitation and Dissemination Plan

Updated version of the project Exploitation and Dissemination Plan PEDR

Production of microalgal-derived EVs

We will generate two SOPs related to 1 the cultivation of a microalgal strains suitable for the production of EVs 2 the production and separation of microalgal EVs

Characterization of EVs

A quality check of EDTMSC and microalgal EVs will be generated it will include size distribution density morphology concentration stability in biological fluids and EVaggregate ratio purity

Data Management Plan

A Data Management Plan will be elaborated considering the H2020 open access rules and research data management to ensure that outputs are findable accessible interoperable and reusable to scientific publications rules

Publikacje

Opportunities and Pitfalls of Fluorescent Labeling Methodologies for Extracellular Vesicle Profiling on High-Resolution Single-Particle Platforms

Autorzy: Fortunato D, Mladenović D, Criscuoli M, Loria F, Veiman K-L, Zocco D, Koort K, Zarovni N
Opublikowane w: International Journal of Molecular Sciences, 2021, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms221910510

Selective isolation of extracellular vesicles from minimally processed human plasma as a translational strategy for liquid biopsies

Autorzy: Diogo Fortunato; Stavros Giannoukakos; Ana Giménez-Capitán; Michael Hackenberg; Miguel A. Molina-Vila; Nataša Zarovni
Opublikowane w: Crossref, Numer 17417007, 2022, ISSN 1741-7007
Wydawca: BioMed Central
DOI: 10.1186/s40364-022-00404-1

Particle profiling of EV-lipoprotein mixtures by AFMnanomechanical imaging

Autorzy: Andrea Ridolfi, Laura Conti, Marco Brucale, Roberto Frigerio, Jacopo Cardellini, Angelo Musicò, Miriam Romano, Andrea Zendrini, Laura Polito, Greta Bergamaschi, Alessandro Gori, Costanza Montis, Stefano Panella, Lucio Barile, Debora Berti, Annalisa Radeghieri, Paolo Bergese, Marina Cretich, Francesco Valle
Opublikowane w: Journal of Extracellular Vesicles, Numer Volume 12, Numer 10, 2023, Strona(/y) n/a, ISSN 2001-3078
Wydawca: Wiley Periodicals LLC on behalf of International Society for Extracellular Vesicle
DOI: 10.1002/jev2.12349

Membrane Phase Drives the Assembly of Gold Nanoparticles on Biomimetic Lipid Bilayers

Autorzy: Jacopo Cardellini, Lucrezia Caselli, Enrico Lavagna, Sebastian Salassi, Heinz Amenitsch, Martino Calamai, Costanza Montis, Giulia Rossi, and Debora Berti*
Opublikowane w: The Journal of Physical Chemistry C, Numer 2022 126 (9), 2022, Strona(/y) 4483–4494, ISSN 1932-7447
Wydawca: American Chemical Society
DOI: 10.1021/acs.jpcc.1c08914

Fluorescent Single-Core and Multi-Core Nanoprobes as Cell Trackers and Magnetic Nanoheaters

Autorzy: García Acevedo, Pelayo; González Gómez Manuel Antonio; Arnosa Prieto Ángela; de Castro Alves Lisandra; Seco Gudiña Román; Piñeiro Yolanda; Rivas José
Opublikowane w: Magnetochemistry, Numer Volume 8; Numer 8, 2022, Strona(/y) 83, ISSN 2312-7481
Wydawca: MDPI
DOI: 10.3390/magnetochemistry8080083

Nanoscale structural and mechanical characterization of thin bicontinuous cubic phase lipid films

Autorzy: Andrea Ridolfi, Ben Humphreys, Lucrezia Caselli, Costanza Montis, Tommy Nylander, Debora Berti, Marco Brucale, Francesco Valle
Opublikowane w: Colloids and Surfaces B: Biointerfaces, Numer Volume 210, February 2022, 2022, Strona(/y) 112231, ISSN 0927-7765
Wydawca: Elsevier BV
DOI: 10.1016/j.colsurfb.2021.112231

Interaction of Metallic Nanoparticles With Biomimetic Lipid Liquid Crystalline Cubic Interfaces

Autorzy: Jacopo Cardellini, Costanza Montis, Francesco Barbero, Ilaria De Santis, Lucrezia Caselli and Debora Berti
Opublikowane w: Frontiers in bioengineering and biotechnology., Numer 22964185, 2022, ISSN 2296-4185
Wydawca: Frontiers
DOI: 10.3389/fbioe.2022.848687

Significant Surface Spin Effects and Exchange Bias in Iron Oxide-Based Hollow Magnetic Nanoparticles

Autorzy: Pelayo García Acevedo; Manuel A. González Gómez; Ángela Arnosa Prieto; Jose S. Garitaonandia; Yolanda Piñeiro; José Rivas
Opublikowane w: Nanomaterials, Vol 12, Iss 456, p 456 (2022), Numer 1, 2021, ISSN 2079-4991
Wydawca: Nanomaterials
DOI: 10.3390/nano12030456

Two Dimensional-Difference in Gel Electrophoresis (2D-DIGE) Proteomic Approach for the Identification of Biomarkers in Endometrial Cancer Serum

Autorzy: Blendi Ura, Stefania Biffi, Lorenzo Monasta, Giorgio Arrigoni, Ilaria Battisti, Giovanni Di Lorenzo, Federico Romano, Michelangelo Aloisio, Fulvio Celsi, Riccardo Addobbati, Francesco Valle, Enrico Rampazzo, Marco Brucale, Andrea Ridolfi, Danilo Licastro, Giuseppe Ricci
Opublikowane w: Cancers, Numer 13/14, 2021, Strona(/y) 3639, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13143639

Versatile magnetic confguration for the control and manipulation of superparamagnetic nanoparticles

Autorzy: Surpi Alessandro; Shelyakova Tatiana; Murgia Mauro; Rivas José; Piñeiro Yolanda; Greco Pierpaolo; Fini Milena; Dediu Valentin Alek
Opublikowane w: Scientific Reports, 2023, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-023-32299-9

Magnetic separation and concentration of Aβ 1–42 molecules dispersed at the threshold concentration for Alzheimer’s disease diagnosis in clinically-relevant volumes of sample

Autorzy: Alessandro Surpi, Mauro Murgia, Sonia López-Amoedo, Manuel A. González-Gómez, Yolanda Piñeiro, José Rivas, Valeria Perugini, Matteo Santin, Tomás Sobrino, Pierpaolo Greco, Francisco Campos, Valentin Alek Dediu
Opublikowane w: Journal of Nanobiotechnology, Numer 21, Article number: 329 (2023), 2023, ISSN 1477-3155
Wydawca: BioMed Central
DOI: 10.1186/s12951-023-02095-8

Biocompatible magnetic gelatin nanoparticles with enhanced MRI contrast performance prepared by single-step desolvation method

Autorzy: C Teijeiro-Valiño, M A González Gómez, S Yáñez, P García Acevedo, A Arnosa Prieto, S Belderbos, W Gsell, U Himmelreich, Y Piñeiro, J Rivas
Opublikowane w: Nano Express, Numer 2/2, 2021, Strona(/y) 020011, ISSN 2632-959X
Wydawca: Nano Express
DOI: 10.1088/2632-959x/abf58e

Impact of the flame retardant 2,2’4,4’-tetrabromodiphenyl ether (PBDE-47) in THP-1 macrophage-like cell function via small extracellular vesicles

Autorzy: Valeria Longo, Noemi Aloi, Alessandra Longo, Giorgia Adamo, Antonella Bongiovanni and Paolo Colombo
Opublikowane w: Front. Immunol, 2022, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2022.1069207

Role of Dipolar Interactions on the Determination of the Effective Magnetic Anisotropy in Iron Oxide Nanoparticles

Autorzy: Pelayo García-Acevedo, Manuel A. González-Gómez, Ángela Arnosa-Prieto, Lisandra de Castro-Alves, Yolanda Piñeiro, and José Rivas
Opublikowane w: Advanced Sciences, Numer Volume 10, Numer 5, February 14, 2023, 2023, Strona(/y) 2203397, ISSN 2198-3844
Wydawca: Wiley-VCH GmbH
DOI: 10.1002/advs.202203397

Multiparametric Orthogonal Characterization of Extracellular Vesicles by Liquid Chromatography Combined with In-Line Light Scattering and Fluorescence Detection

Autorzy: Karl Normak, Marcell Papp, Michael Ullmann, Carolina Paganini, Mauro Manno, Antonella Bongiovanni, Paolo Bergese and Paolo Arosio
Opublikowane w: Analytical Chemistry, Numer Volume 95, Numer 33, August 22, 2023, 2023, Strona(/y) 12195-12574, ISSN 0003-2700
Wydawca: American Chemical Society
DOI: 10.1021/acs.analchem.3c02108

High-Yield Separation of Extracellular Vesicles Using Programmable Zwitterionic Coacervates

Autorzy: Carolina Paganini, Umberto Capasso Palmiero,* Sabrina Picciotto, Alessandro Molinelli, Ilaria Porello, Giorgia Adamo, Mauro Manno, Antonella Bongiovanni, and Paolo Arosio
Opublikowane w: Small, Numer 16136810, 2022, ISSN 1613-6810
Wydawca: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202204736

Synthesis and Characterization of a Biocompatible Nanoplatform Based on Silica-Embedded SPIONs Functionalized with Polydopamine

Autorzy: Miriam Romano, Manuel Antonio González Gómez, Pamela Santonicola, Noemi Aloi, Svenja Offer, Jana Pantzke, Samuele Raccosta, Valeria Longo, Alessandro Surpi, Silvia Alacqua, Giuseppina Zampi, Valentin Alek Dediu, Bernhard Michalke, Ralf Zimmerman, Mauro Manno, Yolanda Piñeiro, Paolo Colombo, Elia Di Schiavi, José Rivas, Paolo Bergese, and Sebastiano Di Bucchianico
Opublikowane w: ACS Biomaterials Science & Engineering, 2023, ISSN 2373-9878
Wydawca: American Chemical Society
DOI: 10.1021/acsbiomaterials.2c00946

Extracellular Vesicles From Microalgae: Uptake Studies in Human Cells and Caenorhabditis elegans

Autorzy: Picciotto; Santonicola; Paterna; Rao; Raccosta; Romancino; Noto; Touzet; Manno; Di Schiavi; Bongiovanni; Adamo
Opublikowane w: Frontiers, Numer 1, 2022, ISSN 2296-4185
Wydawca: Frontiers
DOI: 10.3389/fbioe.2022.830189

An alternative in vitro model considering cell-cell interactions in fiber-induced pulmonary fibrosis

Autorzy: Jana Pantzke and Svenja Offer and Elias J. Zimmermann and Evelyn Kuhn and Thorsten Streibel and Sebastian Oeder and Sebastiano Di Bucchianico and Ralf Zimmermann
Opublikowane w: Toxicology Mechanisms and Methods, 2022, ISSN 1537-6516
Wydawca: Taylor & Francis
DOI: 10.1080/15376516.2022.2156008

Fluorescent Magnetic Mesoporous Nanoprobes for Biotechnological Enhancement Procedures in Gene Therapy

Autorzy: González-Gómez MA, Seco-Gudiña R, García-Acevedo P, Arnosa-Prieto Á, de Castro-Alves L, Piñeiro Y, Rivas J.
Opublikowane w: Magnetochemistry, 2023, ISSN 2312-7481
Wydawca: Magnetochemistry
DOI: 10.3390/magnetochemistry9030067

Probing the coverage of nanoparticles by biomimetic membranes through nanoplasmonics

Autorzy: Cardellini, Jacopo; Ridolfi, Andrea; Donati, Melissa; Giampietro, Valentina; Severi, Mirko; Brucale, Marco; Valle, Francesco; Bergese, Paolo; Montis, Costanza; Caselli, Lucrezia; Berti, Debora
Opublikowane w: Cardellini , J , Ridolfi , A , Donati , M , Giampietro , V , Severi , M , Brucale , M , Valle , F , Bergese , P , Montis , C , Caselli , L & Berti , D 2023 , ' Probing the coverage of nanoparticles by biomimetic membranes through nanoplasmonics ' , Journal of Colloid and Interface Science , vol. 640 , pp. 100-109 . https://doi.org/10.1016/j.jcis.2023.02.073, Numer 1, 2023, Strona(/y) Pages 100-109, ISSN 0021-9797
Wydawca: Academic Press
DOI: 10.1016/j.jcis.2023.02.073

Malignant‐ascites‐derived small extracellular vesicles in advanced ovarian cancer patients: insights into the dynamics of the extracellular matrix

Autorzy: Barbara Bortot, Maura Apollonio, Enrico Rampazzo, Francesco Valle, Marco Brucale, Andrea Ridolfi, Blendi Ura, Riccardo Addobbati, Giovanni Di Lorenzo, Federico Romano, Francesca Buonomo, Chiara Ripepi, Giuseppe Ricci, Stefania Biffi
Opublikowane w: Molecular Oncology, Numer Volume15, Numer12 December 2021, 2021, Strona(/y) Pages 3596-3614, ISSN 1574-7891
Wydawca: Elsevier BV
DOI: 10.1002/1878-0261.13110

Large‐scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshop

Autorzy: Lucia Paolini; Marta Monguió‐Tortajada; Marta Costa; Fabio Antenucci; Mario Barilani; Marta Clos‐Sansalvador; André Cronemberger Andrade; Tom A. P. Driedonks; Sara Giancaterino; Stephanie M. Kronstadt; Rachel R. Mizenko; Muhammad Nawaz; Xabier Osteikoetxea; Carla Pereira; Surya Shrivastava; Anders Toftegaard Boysen; Simonides Immanuel van de Wakker; Martijn J. C. van Herwijnen; Xiaoqin Wang;
Opublikowane w: Paolini , L , Monguió-Tortajada , M , Costa , M , Antenucci , F , Barilani , M , Clos-Sansalvador , M , Andrade , A C , Driedonks , T A P , Giancaterino , S , Kronstadt , S M , Mizenko , R R , Nawaz , M , Osteikoetxea , X , Pereira , C , Shrivastava , S , Boysen , A T , van de Wakker , S I , van Herwijnen , M J C , Wang , X , Watson , D C , Gimona , M , Kaparakis-Liaskos , M , Konstantinov , K ,, Numer 16, 2022, ISSN 2768-2811
Wydawca: Journal of Extracellular Biology
DOI: 10.1002/jex2.63

Effect of glycerol and H3PO4 on the bioactivity and degradability of rod-like SBA-15 particles with active surface for bone tissue engineering applications

Autorzy: Zulema Vargas-Osorio, Artem Klotschan, Marcela Arango-Ospina, Yolanda Piñeiro, Liliana Liverani, José Rivas, Martin Michálek, Dušan Galusek, Aldo R.Boccaccini
Opublikowane w: Microporous and Mesoporous Materials, 2021, ISSN 1387-1811
Wydawca: Elsevier BV
DOI: 10.1016/j.micromeso.2021.111543

Isolation of Extracellular Vesicles From Microalgae: A Renewable and Scalable Bioprocess

Autorzy: Angela Paterna; Estella Rao; Giorgia Adamo; Samuele Raccosta; Sabrina Picciotto; Daniele Romancino; Rosina Noto; Nicolas Touzet; Antonella Bongiovanni; Mauro Manno
Opublikowane w: Crossref, Numer 1, 2022, ISSN 2296-4185
Wydawca: Frontiers
DOI: 10.3389/fbioe.2022.836747

On the interaction and nanoplasmonics of gold nanoparticles and lipoproteins

Autorzy: Andrea Zendrini, Jacopo Cardellini, Roberto Frigerio, Marianna Bertoni, Debora Berti, Paolo Bergese
Opublikowane w: JCIS Open, Special issue for 11th Colloids Conference, Numer Volume 11, October 2023, Article 100088, 2023, ISSN 2666-934X
Wydawca: Elsevier
DOI: 10.1016/j.jciso.2023.100088

The biomolecular corona of extracellular nanoparticles holds new promises for advancing clinical molecular diagnostics

Autorzy: Annalisa Radeghieri and Paolo Bergese
Opublikowane w: Expert Review of Molecular Diagnostics, 2023, ISSN 1744-8352
Wydawca: Taylor & Francis
DOI: 10.1080/14737159.2023.2215927

Extracellular Vesicles Analysis in the COVID-19 Era: Insights on Serum Inactivation Protocols towards Downstream Isolation and Analysis

Autorzy: Roberto Frigerio, Angelo Musicò, Marco Brucale, Andrea Ridolfi, Silvia Galbiati, Riccardo Vago, Greta Bergamaschi, Anna Maria Ferretti, Marcella Chiari, Francesco Valle, Alessandro Gori, Marina Cretich
Opublikowane w: Cells, Numer 10/3, 2021, Strona(/y) 544, ISSN 2073-4409
Wydawca: Cells
DOI: 10.3390/cells10030544

Stiffness of Fluid and Gel Phase Lipid Nanovesicles: Weighting the Contributions of Membrane Bending Modulus and Luminal Pressurization

Autorzy: Andrea Ridolfi, Lucrezia Caselli, Matteo Baldoni, Costanza Montis, Francesco Mercuri, Debora Berti, Francesco Valle, Marco Brucale
Opublikowane w: Langmuir, 2021, ISSN 0743-7463
Wydawca: American Chemical Society
DOI: 10.1021/acs.langmuir.1c01660

Surface functionalization of extracellular vesicle nanoparticles with antibodies: a first study on the protein corona “variable”

Autorzy: Angelo Musicò, Rossella Zenatelli, Miriam Romano, Andrea Zendrini, Silvia Alacqua, Selene Tassoni, Lucia Paolini, Chiara Urbinati, Marco Rusnati, Paolo Bergese, Giuseppe Pomarico, and Annalisa Radeghieri
Opublikowane w: Nanoscale Advances, 5, Numer Numer 18, 2023, 2023, Strona(/y) 4703-4717, ISSN 2516-0230
Wydawca: ROYAL SOCIETY OF CHEMISTRY
DOI: 10.1039/d3na00280b

A plasmon-based nanoruler to probe the mechanical properties of synthetic and biogenic nanosized lipid vesicles

Autorzy: Lucrezia Caselli, Andrea Ridolfi, Jacopo Cardellini, Lewis Sharpnack, Lucia Paolini, Marco Brucale, Francesco Valle, Costanza Montis, Paolo Bergese, Debora Berti
Opublikowane w: Nanoscale Horizons, Numer 6/7, 2021, Strona(/y) 543-550, ISSN 2055-6756
Wydawca: Nanoscale Horizons
DOI: 10.1039/d1nh00012h

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