Periodic Reporting for period 1 - RESETageing (RESEarch for healThy AGEING)
Okres sprawozdawczy: 2021-01-01 do 2022-03-31
As the human expectancy within the European Union continues to increase, the impact of chronic diseases and their dependencies also increase leading to an enormous burden to individuals and to societies. The healthy life expectancy, which is the number of years spent free of disabilities, grows much slower than life expectancy, and this growing has been inequal between EU countries, being Portugal one of the countries where the healthy life expectancy growing has been less significant.
To reduce these gaps in healthy life expectancy, interventions that increase healthy ageing are needed and probably are the most promising potential to relieve individual suffering as well as the enormous strain on public finances.
RESETageing project aims at enhancing the scientific and innovation competences of University of Coimbra (UC), Portugal, a low-performing partner, in the area of cardiovascular ageing, with three high performing partners, University of Newcastle upon Tyne (UNEW), United Kingdom (ageing biology), the University of Maastricht (UM), Netherlands (cardiovascular biology) and the Leibniz Institute on Aging– Fritz Lipmann Institute (LIA), Germany (omics).
The objectives of RESETageing project are to stimulate the excellency in research, training and value creation in the area of ageing.
To reduce these gaps in healthy life expectancy, interventions that increase healthy ageing are needed and probably are the most promising potential to relieve individual suffering as well as the enormous strain on public finances.
RESETageing project aims at enhancing the scientific and innovation competences of University of Coimbra (UC), Portugal, a low-performing partner, in the area of cardiovascular ageing, with three high performing partners, University of Newcastle upon Tyne (UNEW), United Kingdom (ageing biology), the University of Maastricht (UM), Netherlands (cardiovascular biology) and the Leibniz Institute on Aging– Fritz Lipmann Institute (LIA), Germany (omics).
The objectives of RESETageing project are to stimulate the excellency in research, training and value creation in the area of ageing.
Results achieved:
- Identification of senolytic and senostatic drugs by high-throughput screenings using aged cardiac and vascular tissues as platforms;
- Identification of cellular targets for senescence elimination and use of nanoformulations for the release of anti-senescence drugs;
- demonstration of the key role of dysfunctional mitophagy as a driver of the senescence phenotypes
- demonstration of some mechanisms in the communication between senescent cells and proliferative cells.
- Identification of senolytic and senostatic drugs by high-throughput screenings using aged cardiac and vascular tissues as platforms;
- Identification of cellular targets for senescence elimination and use of nanoformulations for the release of anti-senescence drugs;
- demonstration of the key role of dysfunctional mitophagy as a driver of the senescence phenotypes
- demonstration of some mechanisms in the communication between senescent cells and proliferative cells.
Understanding the mechanisms controlling the transition of physiologically normal cells to the senescent state is essential for the development of therapeutic strategies aiming to delay an onset of ageing and age-related diseases. We are studying the effect of the anti-senescence drugs in the senescence program and the characterization of their mechanism of action.
Our data indicate that the loss of mitophagy is sufficient to trigger cellular senescence, therefore activation of mitophagy is required for the anti-senescence effect of pharmacological interventions.
EVs play a major role in cardiac communication, representing an essential mechanism to maintain heart homeostasis.
Our data indicate that the loss of mitophagy is sufficient to trigger cellular senescence, therefore activation of mitophagy is required for the anti-senescence effect of pharmacological interventions.
EVs play a major role in cardiac communication, representing an essential mechanism to maintain heart homeostasis.