Asymmetric synthesis of alpha-amino acids

Cel

Research objectives and content
The main aim of this project is the study of a-amino acid synthesis using new N-dialkylated diketopiperazine based auxiliaries. In order to investigate the regio- and diastereoselective properties of these auxiliaries we shall initiate a programme of research into six areas: 1) An investigation into the general applicability of a novel deprotonation/reprotonation strategy for the preparation of a wide range of a-amino acids.
2) Determination of what protecting groups can be employed for protection on the amidic nitrogens.
3) Development of a new methodology for the preparation of either enantiomer stereospecifically isotopically labelled a-amino acids. 4) Preparation of a wide range of homochiral a,a-bis-alkylated a-amino acids.
5) We wish to implement investigations into a duplication of chirality protocol in order to replicate a-amino acids.
6) Exploration of the possibility of asymmetric synthesis of A,B substituted amino acids by a novel Michael addition approach. Training conent (objective, benefit and expected impact)
I think that I shall be able to acquire new knowledges about other methods of asymmetric synthesis of a wide range of homochiral a-amino acids based on stoichometric chiral auxiliaries which are applicable to large scale synthesis.

Dziedzina nauki

nauki przyrodniczenauki chemicznechemia organicznaaminy

Program(-y)

FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Temat(-y)

Zaproszenie do składania wniosków

Data not available

System finansowania

RGI - Research grants (individual fellowships)

Koordynator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

Adres

South parks road
OX1 3QY Oxford
Zjednoczone Królestwo

Wkład UE

Brak danych

Uczestnicy (1)

Not available

Hiszpania