Cel The main objectives are as follows:* Assessment the extent and significance of resistance to trypanocidal drugs in selected areas of East and Southern Africa.* Elucidation of the relationship between existing trypanocidal drug use in cattle, both prophylactic and therapeutic, and the development, extent and significance of resistance to trypanocidal drugs.* Investigation of the importance of trypanocidal drug resistance and implications thereof for the efficacy of trypanocidal use, both prophylactic and therapeutic.* Provision of a rational basis for sound use of prophylactic and therapeutic drugs in the control of bovine trypanosomiasis, with a view to minimizing the development and spread of trypanocidal drug resistance.* Provision of National Agricultural Research Systems (NARS) with techniques which will enable them to make recommendations to national and regional tsetse and trypanosomiasis control programmes for the improvement of trypanosomiasis control strategies.* Contribution to the development of a simple test for diagnosis of drug-resistant trypanosome infections and to the international standardisation of trypanocidal drug resistance testing.Expected OutcomeThe proposed project activities will result in the provision of appropriate technologies for evaluating the importance of drug-resistance in the control of bovine trypanosomiasis and for studying its epidemiology on a larger scale than has been possible in the past. The proposed work involves the transfer of the latest novel techniques for the investigation of trypanocidal drug resistance from the EU and international institutes in which they were developed, to the African DC institutes which are faced with the task of investigating and controlling the problem of tsetse-transmitted bovine trypanosomiasis.The key activities are :* Field activities* Selection of study sites.* Field methods of trypanosome infections.* Obtaining samples from cattle in the field.* Obtaining background epidemiological data of cattle in the field.* Laboratory activities* Implementation of methods of identifying trypanocidal drug resistance.* Validation of the new Ag-ELISA.* Diagnosis of trypanosome infections by Ag-ELISA.* Training of national counterpart staff* Data analysis* Creation and maintenance of personal computer databases.* Demonstration of drug resistance in trypanosomes.* Calculation of the prevalence of drug resistant trypanosomes.* Design of improved trypanosomiasis control strategies based on the prevalence of drug resistant trypanosomes.* Provision of recommendations* Recommendations to the National and Regional Tsetse and Trypanosomiasis Control Programmes for the improvement of trypanosomiasis control strategies.* Workshop* Dissemination of results and recommendations.* Recommendations for the international standardization of trypanocidal drug resistance testing. Dziedzina nauki natural sciencescomputer and information sciencesdata sciencenatural sciencescomputer and information sciencesdatabasesmedical and health scienceshealth sciencespublic healthepidemiologymedical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceagricultural sciencesanimal and dairy sciencedomestic animalsanimal husbandry Program(-y) FP4-INCO - Specific research, technological development and demonstration programme in the field of cooperation with third countries and international organizations, 1994-1998 Temat(-y) 03010205 - Animal production Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator University of Glasgow Wkład UE Brak danych Adres Bearsden Road G61 1QH Glasgow Zjednoczone Królestwo Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (6) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko Animal Diseases Research Institute, Dar Es Salaam Tanzania Wkład UE Brak danych Adres 50 Dar Es Salaam Zobacz na mapie Koszt całkowity Brak danych Central Veterinary Research Institute Zambia Wkład UE Brak danych Adres Balmoral 10101 Lusaka Zobacz na mapie Koszt całkowity Brak danych INTERNATIONAL LIVESTOCK RESEARCH INSTITUTE Kenia Wkład UE Brak danych Adres Naivasha Road 00503 KABETE Zobacz na mapie Koszt całkowity Brak danych Instituut voor Tropische Geneeskunde Prins Leopold Belgia Wkład UE Brak danych Adres Nationalestraat 2000 Antwerpen Zobacz na mapie Koszt całkowity Brak danych International Atomic Energy Agency Austria Wkład UE Brak danych Adres 5,Wagramerstrasse 5 2444 Seibersdorf Zobacz na mapie Koszt całkowity Brak danych Kenya Trypanosomiasis Research Institute Kenia Wkład UE Brak danych Adres 124 Kikuyu Zobacz na mapie Koszt całkowity Brak danych