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Modulation of foldases for oversproduction of heterologous proteins in streptomycess

Cel

Improving the yield of correctly folded heterologous proteins which contain disulfide bonds by stroptomyces lividans may require the assistance of thioldisulfide oxyreductases. As a model the role of various protein disulfide isomerases in the expression and secretion of the h. Medicinalis thrombin inhibitor hirudin will be studied.

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JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT
Wkład UE
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11,Marie-Curie-Strasse 11
60439 FRANKFURT AM-MAIN
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