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Synthesis and mechanism of action of novel classes of retinoids and rexinoids with antineoplastic activities

Cel

In vitro studies, clinical trials and the cure of acute promyelocytic leukemiahave unequivocally demonstrated the cancer therapeutic and cancer preventive action of retinues and resinous. We will generate novel types of legends that activate only a specific function and/or receptor isotope and define itscoregulator interaction pattern. We will identify anti-cancer drugs which exploit the
(1) link between retinues and selective-selective TRAIL death signalling,
(2) autonomous reined signalling that controls cell differentiation and apoptosis,
(3) activation by HDAC or methylamine inhibitors of growth regulation in retinoidnon-responsive cells,
(4) crosswalk with other signalling pathways that can prevent chemical carcinogen sis, and
(5) anti-viral action. The present consortium combines experts of different disciplines to chemically synthesize, screen and characterize novel ret (x) inroads and investigate the molecular basis of their anticancer action.

Koordynator

UNIVERSITY OF VIGO
Adres

36200 Vigo
Hiszpania

Uczestnicy (6)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Francja
Adres
Rue Michel Ange 3
75794 Paris
GALDERMA RESEARCH AND DEVELOPMENT
Francja
Adres
Route Des Lucioles 635
06902 Sophia Antipolis
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Francja
Adres
Rue De Tolbiac, 101
75654 Paris
ISTITUTO NAZIONALE TUMORI CENTROEUROPEO
Włochy
Adres
Via Pedemontana Occidentale 12
33081 Aviano
SECONDA UNIVERSITA DEGLI STUDI DI NAPOLI
Włochy
Adres
Viale Beneduce 10
81100 Caserta
UNIVERSITÀ DEGLI STUDI DI FERRARA
Włochy
Adres
Via Borsari, 46
44100 Ferrara