Cel NEONUCLEI will develop transcription-competent synthetic analogues of cell nuclei. These particles, termed neonuclei, will be obtained through self-assembly/organisation in mixtures of DNA, macromolecules (or nanoparticles), and lipids. The composition o f the neonuclei will be chosen to produce particles with internal nano-architectures capable of sustaining gene transcription upon the addition of transcription factors. These design of the static architectures of the neonuclei and their dynamic propert ies will be guided by observations on real nuclei. The DNA of the neonuclei will contain a gene cluster (or tandem repeats of the same gene). The genes will be separated by sequences designed to induce DNA compaction in response to specific chemical or p hysical stimuli. This will be exploited to establish non-biological control over the transcription of parts, or all, of the DNA. These control sequences offer the opportunity for multiple transcription control strategies and provide the capability of im plementing temporally co-ordinated synthesis of multiple gene products. Neonuclei represent a key enabling step in the realisation of semi-biotic systems; these are systems and devices that combine synthetic non-natural functional systems with systems o f biological origin. The neonuclei will be integrated with biological systems, or with isolated components, to produce novel semi-biotic devices capable of the controlled in situ synthesis of complex bio-molecules on demand. Dziedzina nauki nauki przyrodniczenauki biologicznegenetykaDNAnauki przyrodniczenauki biologicznebiochemiabiocząsteczkilipidyinżynieria i technologiananotechnologiananomateriały Słowa kluczowe Nanotechnology Risk Assessment Program(-y) FP6-POLICIES - Policy support: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Temat(-y) NEST-2003-1 - Adventure activities Zaproszenie do składania wniosków FP6-2003-NEST-PATH Zobacz inne projekty w ramach tego zaproszenia System finansowania STREP - Specific Targeted Research Project Koordynator UNIVERSITY OF SOUTHAMPTON Adres University road, highfield Southampton Zjednoczone Królestwo Zobacz na mapie Linki Strona internetowa Opens in new window Wkład UE Brak danych Uczestnicy (4) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko LUNDS UNIVERSITET Szwecja Wkład UE € 0,00 Adres Paradisgatan 5c Lund Zobacz na mapie Linki Strona internetowa Opens in new window Środki z innych źródeł Brak danych CHALMERS TEKNISKA HOGSKOLA AB Szwecja Wkład UE € 0,00 Adres Chalmersplatsen 4 Goteborg Zobacz na mapie Linki Strona internetowa Opens in new window Środki z innych źródeł Brak danych UNIVERSIDADE DE COIMBRA Portugalia Wkład UE € 0,00 Adres Hospitais da universidade de coimbra - praceta mota pinto Coimbra Zobacz na mapie Linki Strona internetowa Opens in new window Środki z innych źródeł Brak danych LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Niemcy Wkład UE € 0,00 Adres Geschwister-scholl-platz 1 Muenchen Zobacz na mapie Linki Strona internetowa Opens in new window Środki z innych źródeł Brak danych
