Final Report Summary - MODOPCFATE (Modulation of oligodendrocyte precursor cells differentiation fate during CNS remyelination.)
A key aspect of neural repair is that none of observed cellular and molecular events are occurring in isolation. We observe that migrating OPCs preferentially associate with blood vessels, and on the other hand, the blood vessels undergo substantial regeneration in course of remyelination. These two processes are integrated forming a neurovascular niche during tissue reorganization. Our analysis shown that unique properties of tissue around blood vessels differ from the rest of the lesion which can be one of the factors favoring OPCs alternative differentiation in this area of lesion.
The gain-of-function and loss-of-function in vitro experiments verifying which endothelial-derived factors prompt OPCs proliferation and alternative differentiation are a subject of our currently on-going project which is an original concept based on promising results obtained during our work on reported project. Our data can potentially have an impact on the current understanding of the phenomenon of remyelination by endogenous multipotential precursors as well as influence the development of new therapeutic opportunities by selectively targeting cellular plasticity-related phenomena. In the long-term perspective, we expect that modulation of signals from the vascular environment may be crucial for the development of therapeutic strategies targeting both enhancement of endogenous remyelination and tissue regeneration after transplantation of exogenous cells.