Cel Fast developments in synthetic biology now enable introduction of entire novel-to-nature pathways into industrial microorganisms, thus opening the door to a novel bio-based industry. However, successful scale-up of novel-to-market products from bench-top proof-of-principle to full-scale processes requires a profound understanding of cellular and sub-cellular mechanisms and their interaction with industrial process conditions. In particular, successful industrial production requires optimal performance of engineered strains under the dynamic, slow-growth process conditions that occur in large-scale industrial bioreactors. These differ strongly from the conditions in conventional laboratory analysis.The RoBoYeast project aims to reduce time-to-market and to improve productivity of microbial synthetic pathways by identifying key physiological and molecular determinants of performance under industrially relevant conditions and to integrate these at an early stage in strain development programs. The project is characterized by multi-scale analysis and integration of results from industrial-scale into lab-scale studies.RoBoYeast aims to improve productivity and cellular robustness in large-scale fermentations of the novel-to-nature production in Saccharomyces cerevisiae of arachidonic and eicosapentaenoic acid, two health-promoting poly-unsaturated fatty acids with excellent market perspectives as nutraceuticals. Biosynthetic pathways of these compounds are energy (ATP) intensive, which adds on the challenge of constructing robust strains that withstand typical production stresses without loss of productivity and product yield. To accelerate project progress, key findings of a likewise challenging resveratrol progress, already developed by the SME partner, can be used. RoBoYeast intends to identify and improve robustness mechanism not only for the benefit of this project but also as a blueprint for optimization of the production of other ATP-intensive products. Dziedzina nauki engineering and technologyenvironmental biotechnologybioremediationbioreactorsnatural sciencesbiological sciencessynthetic biologynatural sciencesbiological sciencesbiochemistrybiomoleculeslipidssocial scienceseconomics and businesseconomicsproduction economicsproductivityengineering and technologyindustrial biotechnologybioprocessing technologiesfermentation Program(-y) FP7-KBBE - Specific Programme "Cooperation": Food, Agriculture and Biotechnology Temat(-y) KBBE.2011.3.3-03 - Cellular, metabolic and genetic engineering for novel compounds Zaproszenie do składania wniosków FP7-KBBE-2011-5 Zobacz inne projekty w ramach tego zaproszenia System finansowania CP-TP - Collaborative Project targeted to a special group (such as SMEs) Koordynator UNIVERSITY OF STUTTGART Wkład UE € 709 270,00 Adres KEPLERSTRASSE 7 70174 Stuttgart Niemcy Zobacz na mapie Region Baden-Württemberg Stuttgart Stuttgart, Stadtkreis Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Ralf Takors (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (2) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko TECHNISCHE UNIVERSITEIT DELFT Niderlandy Wkład UE € 834 958,00 Adres STEVINWEG 1 2628 CN Delft Zobacz na mapie Region West-Nederland Zuid-Holland Delft en Westland Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Rogier Van Loghem Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych FLUXOME SCIENCES A/S Dania Wkład UE € 527 119,00 Adres DIPLOMVEJ 378 2800 LYNGBY Zobacz na mapie Rodzaj działalności Private for-profit entities (excluding Higher or Secondary Education Establishments) Kontakt administracyjny Sarah Barrett (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
