Dissecting the gene regulatory mechanisms that generate serotonergic neurons

Informacje na temat projektu

SEROTONIN

Identyfikator umowy o grant: 293763

Projekt został zamknięty

Data rozpoczęcia 1 Września 2011

Data zakończenia 31 Sierpnia 2015

Finansowanie w ramach

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Koszt całkowity € 100 000,00

Wkład UE € 100 000,00

Koordynowany przez

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain

Cel

Mental disorders constitute a human and economic burden for developed countries. Many mental disorders have been linked to serotonin dysfunction, but the precise mechanisms underlying these defects are not well understood. Serotonin Related Mental Disorders (SRMD) are multigenic, which makes the identification of these mechanisms a very difficult task. Understanding the molecular mechanisms that generate serotonergic neurons may provide the tools required for the identification of the mutations that would predispose to SRMD. In this grant we will use a multidisciplinary approach to dissect the transcriptional mechanisms that generate serotonergic neurons. Serotonergic neurons are very ancient in evolution and enzymes and transporters responsible for the production of serotonin (serotonin pathway genes) are highly conserved in all metazoans. We will take advantage of this evolutionary conservation and use the genetic amenability of C. elegans to dissect the genetic mechanisms responsible for the generation of the serotonergic neurons. Next, we will apply the lessons learned from C. elegans to unravel analogous mechanisms regulating mouse serotonergic differentiation. Our preliminary results show that the serotonergic pathway genes are co-regulated by the same factors, and that this mechanism is evolutionary conserved. We will identify the cis-acting sequences (serotonergic motif) and trans-acting factors responsible for the activation of the serotonergic features, both in worms and mice. Finally, we will apply our knowledge on serotonergic differentiation to generate serotonergic neurons in vitro. If successful, this project should lead to (i) the identification of the fundamental mechanisms underlying the specification of serotonergic neurons, and (ii) the generation of new tools to understand and treat SRMD.

Dziedzina nauki (EuroSciVoc)

Klasyfikacja projektów w serwisie CORDIS opiera się na wielojęzycznej taksonomii EuroSciVoc, obejmującej wszystkie dziedziny nauki, w oparciu o półautomatyczny proces bazujący na technikach przetwarzania języka naturalnego. Więcej informacji: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc

• medycyna i nauki o zdrowiu › medycyna kliniczna › psychiatria
• nauki przyrodnicze › nauki biologiczne › genetyka › mutacja
• nauki przyrodnicze › nauki biologiczne › biochemia › biocząsteczki › białka › enzymy

Aby użyć tej funkcji, musisz się zalogować lub zarejestrować

Program(-y)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Temat(-y)

• FP7-PEOPLE-2011-CIG - Marie-Curie Action: "Career Integration Grants"

Zaproszenie do składania wniosków

FP7-PEOPLE-2011-CIG
Zobacz inne projekty w ramach tego zaproszenia

System finansowania

MC-CIG - Support for training and career development of researcher (CIG)

Koordynator

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

• Wkład UE: € 100 000,00
• Adres: CALLE SERRANO 117 ; 28006 Madrid ; Hiszpania
• Region: Comunidad de Madrid › Comunidad de Madrid › Madrid
• Rodzaj działalności: Research Organisations
• Koszt całkowity: Brak danych