Cel
Chronic kidney disease (CKD) affects 8% of the European population and ultimately results in renal failure due to progressive fibrosis. CDK carries a high mortality risk and the number of affected people rises, increasing the demand on renal replacement therapies while the number of available donor organs stays stable.
The STELLAR consortium proposes to develop an alternative to renal replacement therapy, based on the repair capacity of newly discovered kidney mesenchymal stromal cells (kMSCs). By injecting kMSC into affected kidneys, we expect to stop kidney fibrosis and induce tissue repair, ultimately leading to the restoration of normal kidney function.
The STELLAR consortium will
• develop protocols for up scalable, high quality isolation of kMSCs and precisely characterize kMSC function in comparison to other MSCs.
• test kMSCs in several murine renal disease models, to study their effects on fibrosis and tissue repair.
• discover mechanisms of kidney repair.
• invest in developing the technology necessary for up scaled isolation and quality control.
The STELLAR consortium combines Australian experts on kMSC isolation and characterisation with European experts on renal failure and compounds the state-of-the-art knowledge, facilities and experience needed to develop and validate this novel form of renal therapy. The inclusion of experienced SMEs, with great technical and scientific know-how about assay and protocol development, further strengthens the consortium and will ensure not only the inclusion of new technology, but also a quick translation from bench to clinical application.
In conclusion, the STELLAR consortium is capable of developing and pre clinical validation of this new cellular therapy for CDK, based on a new understanding of stromal cells and fibroblast function, while also providing the technology required for rapid, large scale application of the therapy after clinical validation.
Dziedzina nauki
Zaproszenie do składania wniosków
FP7-HEALTH-2012-INNOVATION-1
Zobacz inne projekty w ramach tego zaproszenia
System finansowania
CP-FP - Small or medium-scale focused research projectKoordynator
2333 ZA Leiden
Niderlandy
Zobacz na mapie
Uczestnicy (15)
4072 Brisbane
Zobacz na mapie
20156 Milano
Zobacz na mapie
50121 Florence
Zobacz na mapie
SW7 2AZ LONDON
Zobacz na mapie
1210 WIEN
Zobacz na mapie
3723 MB Bilthoven
Zobacz na mapie
51429 Bergish Gladbach
Zobacz na mapie
Zakończenie uczestnictwa
7522 NB Enschede
Zobacz na mapie
1405 EE Bussum
Zobacz na mapie
3205 SOUTH MELBOURNE
Zobacz na mapie
24127 Bergamo
Zobacz na mapie
WC2R 2LS London
Zobacz na mapie
3052 Parkville
Zobacz na mapie
6200 MD Maastricht
Zobacz na mapie
3723 MB Bilthoven
Zobacz na mapie