Cel This H2020-FETOPEN-2016-2017 proposal initiates a major international effort to direct polymorphism in pharmaceutical compounds through crystallizing in high magnetic fields. The ability to direct polymorphism would have a transformative effect on almost all pharmaceutical compounds, and hence on society.It is proposed that MagnaPharm will drive forward innovation in pharmaceuticals by exploiting our new discovery that the polymorph and properties of carbamazepine, indomethacin and coronene can be controlled through the application of magnetic fields. We will apply our method to a range of pharmaceutical compounds, as guided by our project partner AstraZeneca, one of the largest pharmaceutical companies in the world. We will initially target 12 of the most high-profile, high-worth generic drugs with the aim of controllably synthesizing the desired polymorph of each (the lowest-energy polymorph and/or most processable form with desired properties). We aim for this goal via an international multidisciplinary approach centred around our discovery, underpinned by the development of a profound theoretical understanding of the effects of magnetic fields on organic crystal growth, that will direct the synthetic effort, all drawing on results from cutting edge spectroscopic and crystallographic characterisations.With the 12 representative generic drug molecules targeted in the initial stages of MagnaPharm responsible for €18 billion of sales per year worldwide, and the development of many new pharmaceuticals being hampered by solid form issues, control over the production of the most pharmaceutically desired crystal is a truly paradigm-shifting prospect. Dziedzina nauki engineering and technologymaterials engineeringcrystalsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs Program(-y) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Temat(-y) FETOPEN-01-2016-2017 - FET-Open research and innovation actions Zaproszenie do składania wniosków H2020-FETOPEN-2016-2017 Zobacz inne projekty w ramach tego zaproszenia Szczegółowe działanie H2020-FETOPEN-1-2016-2017 System finansowania RIA - Research and Innovation action Koordynator UNIVERSITY OF BRISTOL Wkład UE netto € 1 195 677,50 Adres BEACON HOUSE QUEENS ROAD BS8 1QU Bristol Zjednoczone Królestwo Zobacz na mapie Region South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 1 195 677,50 Uczestnicy (3) Sortuj alfabetycznie Sortuj według wkładu UE netto Rozwiń wszystko Zwiń wszystko UNIVERSITY COLLEGE LONDON Zjednoczone Królestwo Wkład UE netto € 775 673,75 Adres GOWER STREET WC1E 6BT London Zobacz na mapie Region London Inner London — West Camden and City of London Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 775 673,75 STICHTING RADBOUD UNIVERSITEIT Niderlandy Wkład UE netto € 360 031,25 Adres HOUTLAAN 4 6525 XZ Nijmegen Zobacz na mapie Region Oost-Nederland Gelderland Arnhem/Nijmegen Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 360 031,25 UNIVERSITY OF LIMERICK Irlandia Wkład UE netto € 554 941,25 Adres NATIONAL TECHNOLOGICAL PARK, PLASSEY - Limerick Zobacz na mapie Region Ireland Northern and Western Border Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 554 941,25