Skip to main content
Przejdź do strony domowej Komisji Europejskiej (odnośnik otworzy się w nowym oknie)
polski pl
CORDIS - Wyniki badań wspieranych przez UE
CORDIS

Fine-tuning the brain’s brakes – modulating inhibitory control with transcranial alternating current stimulation

Cel

Inhibitory control over unwanted thoughts, emotions and movements is essential for effective interaction with our environment. This becomes particularly evident when there is too little inhibition, as in obsessive-compulsive disorder or Tourette’s syndrome, or too much, as in Parkinson’s disease. Recent evidence links successful inhibition to the power of neural oscillations in the beta band (15-30Hz) in a circuit involving the frontal cortex and the subthalamic nucleus. While this is an important step forward, it is not yet sufficient to develop effective neuromodulatory treatments for inhibitory control disorders. For that, we need to understand how the beta oscillations mediate neuronal communication within the fronto-subthalamic circuit.
In this proposal, I address this challenging question through novel applications of transcranial alternating current stimulation (tACS). This non-invasive brain stimulation technique aligns neuronal oscillations to an oscillating low-intensity electrical current applied to the brain. This external control over oscillatory power and phase will allow me to investigate: (1) the functional relevance of beta oscillatory phase, and (2) the causal role of interactions between beta oscillations and other frequency bands (‘cross-frequency coupling’). Subsequently, I will develop an innovative, non-invasive, treatment strategy for inhibitory control deficits, by recording and modulating abnormal circuit activity only when present.
Maastricht University is the ideal place to perform this research program as it is one of the only institutes in the world that has access to a new generation of deep brain stimulators, enabling concurrent recording of cortical and subthalamic activity, and it houses one of the pioneering groups in using oscillation-based non-invasive brain stimulation. Integration within this multidisciplinary team will offer an exceptional opportunity to increase my skill set, and capability to launch my own research group.

Dziedzina nauki (EuroSciVoc)

Słowa kluczowe

Program(-y)

Temat(-y)

System finansowania

MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

Wyświetl wszystkie projekty finansowane w ramach tego programu finansowania

Zaproszenie do składania wniosków

(odnośnik otworzy się w nowym oknie) H2020-MSCA-IF-2017

Wyświetl wszystkie projekty finansowane w ramach tego zaproszenia

Koordynator

UNIVERSITEIT MAASTRICHT
Wkład UE netto
€ 165 598,80
Adres
MINDERBROEDERSBERG 4
6200 MD Maastricht
Niderlandy
Region
Zuid-Nederland Limburg (NL) Zuid-Limburg
Rodzaj działalności
Higher or Secondary Education Establishments
Linki
Koszt całkowity
€ 165 598,80